Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia.
Witcher KG, Bray CE, Chunchai T, Zhao F, O'Neil SM, Gordillo AJ, Campbell WA, McKim DB, Liu X, Dziabis JE, Quan N, Eiferman DS, Fischer AJ, Kokiko-Cochran ON, Askwith C, Godbout JP.
Witcher KG, et al. Among authors: fischer aj.
J Neurosci. 2021 Feb 17;41(7):1597-1616. doi: 10.1523/JNEUROSCI.2469-20.2020. Epub 2021 Jan 15.
J Neurosci. 2021.
PMID: 33452227
Free PMC article.
In cortical neurons, genes associated with dopamine signaling, long-term potentiation, calcium signaling, and synaptogenesis were suppressed. ...Collectively, these studies indicate that microglia promote persistent neuropathology and long-term functional impairment …
In cortical neurons, genes associated with dopamine signaling, long-term potentiation, calcium signaling, and synaptogenesis were sup …