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Contemporary in-hospital and long-term prognosis of patients with acute ST-elevation myocardial infarction depending on renal function: a retrospective analysis.
Engelbertz C, Feld J, Makowski L, Kühnemund L, Fischer AJ, Lange SA, Günster C, Dröge P, Ruhnke T, Gerß J, Freisinger E, Reinecke H, Köppe J. Engelbertz C, et al. Among authors: fischer aj. BMC Cardiovasc Disord. 2023 Feb 2;23(1):62. doi: 10.1186/s12872-023-03084-3. BMC Cardiovasc Disord. 2023. PMID: 36732721 Free PMC article.
BACKGROUND: Cardiovascular disease is often associated with chronic kidney disease (CKD), resulting in an increased risk for poor outcome. We sought to determine short-term mortality and overall survival in ST-elevation myocardial infarction (STEMI) patients with different …
BACKGROUND: Cardiovascular disease is often associated with chronic kidney disease (CKD), resulting in an increased risk for poor outcome. W …
ST-Elevation Myocardial Infarction as a First Event.
Fischer AJ, Feld J, Makowski L, Engelbertz C, Kühnemund L, Günster C, Dröge P, Ruhnke T, Gerß J, Freisinger E, Reinecke H, Köppe J. Fischer AJ, et al. Dtsch Arztebl Int. 2022 Apr 22;119(16):284-292. doi: 10.3238/arztebl.m2022.0161. Dtsch Arztebl Int. 2022. PMID: 35314025 Free PMC article.
The primary endpoints were 30-day mortality, reinfarction or death, major adverse cardiovascular and cerebro - vascular events (MACCE), long-term survival for more than 90 days, and overall survival (OS). RESULTS: STEMI occurred in 17 444 patients (32.8% women). ...
The primary endpoints were 30-day mortality, reinfarction or death, major adverse cardiovascular and cerebro - vascular events (MACCE), long …
Sex-related differences in treatment and outcome of chronic limb-threatening ischaemia: a real-world cohort.
Makowski L, Köppe J, Engelbertz C, Kühnemund L, Fischer AJ, Lange SA, Dröge P, Ruhnke T, Günster C, Malyar N, Gerß J, Freisinger E, Reinecke H, Feld J. Makowski L, et al. Among authors: fischer aj. Eur Heart J. 2022 May 7;43(18):1759-1770. doi: 10.1093/eurheartj/ehac016. Eur Heart J. 2022. PMID: 35134893 Free PMC article.
In the present study, we included CLTI patients and studied sex-related differences in their risk profile, vascular procedures, and long-term outcome. METHODS AND RESULTS: We analysed 199 953 unselected patients of the largest public health insurance in Germany (AOK: Local …
In the present study, we included CLTI patients and studied sex-related differences in their risk profile, vascular procedures, and long- …
Antiarrhythmic drugs-safety and efficacy during pregnancy.
Fischer AJ, Diller GP, Uebing A, Nürnberg JH, Hebe J. Fischer AJ, et al. Herzschrittmacherther Elektrophysiol. 2021 Jun;32(2):145-151. doi: 10.1007/s00399-021-00759-2. Epub 2021 Mar 29. Herzschrittmacherther Elektrophysiol. 2021. PMID: 33779803 Review. English.
In clinical practice, AAD predominantly used during pregnancy are intravenous adenosine for acute treatment of atrioventricular nodal dependent tachycardias, whereas betablockers, sotalol, and flecainide can be orally administered for long-term therapy....
In clinical practice, AAD predominantly used during pregnancy are intravenous adenosine for acute treatment of atrioventricular nodal depend …
Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia.
Witcher KG, Bray CE, Chunchai T, Zhao F, O'Neil SM, Gordillo AJ, Campbell WA, McKim DB, Liu X, Dziabis JE, Quan N, Eiferman DS, Fischer AJ, Kokiko-Cochran ON, Askwith C, Godbout JP. Witcher KG, et al. Among authors: fischer aj. J Neurosci. 2021 Feb 17;41(7):1597-1616. doi: 10.1523/JNEUROSCI.2469-20.2020. Epub 2021 Jan 15. J Neurosci. 2021. PMID: 33452227 Free PMC article.
In cortical neurons, genes associated with dopamine signaling, long-term potentiation, calcium signaling, and synaptogenesis were suppressed. ...Collectively, these studies indicate that microglia promote persistent neuropathology and long-term functional impairment …
In cortical neurons, genes associated with dopamine signaling, long-term potentiation, calcium signaling, and synaptogenesis were sup …
Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia.
Mülling K, Fischer AJ, Siakaeva E, Richter M, Bordbari S, Spyra I, Köster C, Hermann DM, Gunzer M, Felderhoff-Müser U, Bendix I, Jablonska J, Herz J. Mülling K, et al. Among authors: fischer aj. Brain Behav Immun. 2021 Feb;92:234-244. doi: 10.1016/j.bbi.2020.12.012. Epub 2020 Dec 14. Brain Behav Immun. 2021. PMID: 33333168 Free article.
Neonatal encephalopathy following hypoxia-ischemia (HI) is a major cause of long-term morbidity and mortality in children. Even though HI-induced neuroinflammation, involving infiltration of peripheral immune cells into the CNS has been associated with disease pathogenesis …
Neonatal encephalopathy following hypoxia-ischemia (HI) is a major cause of long-term morbidity and mortality in children. Even thoug …
Sustained Coinfections with Staphylococcus aureus and Pseudomonas aeruginosa in Cystic Fibrosis.
Fischer AJ, Singh SB, LaMarche MM, Maakestad LJ, Kienenberger ZE, Peña TA, Stoltz DA, Limoli DH. Fischer AJ, et al. Am J Respir Crit Care Med. 2021 Feb 1;203(3):328-338. doi: 10.1164/rccm.202004-1322OC. Am J Respir Crit Care Med. 2021. PMID: 32750253 Free PMC article.
Contrary to common assumption, we found no pattern of replacement of S. aureus by P. aeruginosa. Many patients with CF have durable long-term coinfection with these organisms. New strategies are needed to prevent and treat these infections....
Contrary to common assumption, we found no pattern of replacement of S. aureus by P. aeruginosa. Many patients with CF have durable long- …
[Anatomic pitfalls and challenges of His bundle pacing].
Fischer AJ, Nagarajan VD, Ho SY, Diller GP, Ernst S. Fischer AJ, et al. Herzschrittmacherther Elektrophysiol. 2020 Jun;31(2):104-110. doi: 10.1007/s00399-020-00680-0. Epub 2020 May 6. Herzschrittmacherther Elektrophysiol. 2020. PMID: 32377904 Review. German.
Long-term right ventricular apical pacing is known to be deleterious for left ventricular function leading to the clinical picture of heart failure with all the possibly associated complications, ranging up to death of the affected patient. ...
Long-term right ventricular apical pacing is known to be deleterious for left ventricular function leading to the clinical picture of …
Altered mucosa-associated microbiota in the ileum and colon of neonatal calves in response to delayed first colostrum feeding.
Ma T, O'Hara E, Song Y, Fischer AJ, He Z, Steele MA, Guan LL. Ma T, et al. Among authors: fischer aj. J Dairy Sci. 2019 Aug;102(8):7073-7086. doi: 10.3168/jds.2018-16130. Epub 2019 Jun 13. J Dairy Sci. 2019. PMID: 31202657 Free article.
Twenty-seven male Holstein calves were randomly assigned to 1 of 3 groups, fed colostrum at 45 min, 6 h, and 12 h after birth, respectively. Ileum and colon mucosa were collected at 51 h after birth, and their associated microbial profiles were assessed using amplic …
Twenty-seven male Holstein calves were randomly assigned to 1 of 3 groups, fed colostrum at 45 min, 6 h, and 12 h after birth, respec …
Surfactant deficiency syndrome in an infant with a C-terminal frame shift in ABCA3: A case report.
Akil N, Fischer AJ. Akil N, et al. Among authors: fischer aj. Pediatr Pulmonol. 2018 May;53(5):E12-E14. doi: 10.1002/ppul.23994. Epub 2018 Mar 22. Pediatr Pulmonol. 2018. PMID: 29566461 Free PMC article.
ABCA3 transports phospholipids into the lamellar bodies of type II alveolar cells, a critical step in alveolar surfactant production. We report a term infant with ABCA3 surfactant deficiency syndrome with the E292V (c.875A>T; p.Glu292Val) mutation in trans with a novel …
ABCA3 transports phospholipids into the lamellar bodies of type II alveolar cells, a critical step in alveolar surfactant production. We rep …
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