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Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model.
Dorrell C, Peters AM, Zhang Q, Balaji N, Baradar K, Mochizuki-Kashio M, Major A, Finegold M, Liu CW, Lu K, Grompe M. Dorrell C, et al. Among authors: finegold m. bioRxiv [Preprint]. 2023 Aug 16:2023.08.16.553572. doi: 10.1101/2023.08.16.553572. bioRxiv. 2023. PMID: 37649908 Free PMC article. Preprint.
In addition, the percentage of quiescent HSC (LSK) was significantly increased (p=0.001) by long-term treatment with MET alone. However, the absolute number of progenitors, measured by LSK frequency or CFU-S, was not significantly altered by MET therapy. ...Importantly, no …
In addition, the percentage of quiescent HSC (LSK) was significantly increased (p=0.001) by long-term treatment with MET alone. Howev …
Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements.
Harpavat S, Garcia-Prats JA, Anaya C, Brandt ML, Lupo PJ, Finegold MJ, Obuobi A, ElHennawy AA, Jarriel WS, Shneider BL. Harpavat S, et al. Among authors: finegold mj. JAMA. 2020 Mar 24;323(12):1141-1150. doi: 10.1001/jama.2020.0837. JAMA. 2020. PMID: 32207797 Free PMC article.
RESULTS: Of 124 385 newborns in the screening study, 49.2% were female, 87.6% were of term gestational age, 70.0% were white, and 48.1% were Hispanic. ...
RESULTS: Of 124 385 newborns in the screening study, 49.2% were female, 87.6% were of term gestational age, 70.0% were white, and 48. …
Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin.
Katz TA, Grimm SL, Kaushal A, Dong J, Treviño LS, Jangid RK, Gaitán AV, Bertocchio JP, Guan Y, Robertson MJ, Cabrera RM, Finegold MJ, Foulds CE, Coarfa C, Walker CL. Katz TA, et al. Among authors: finegold mj. Environ Health Perspect. 2020 Jan;128(1):17010. doi: 10.1289/EHP5414. Epub 2020 Jan 15. Environ Health Perspect. 2020. PMID: 31939706 Free PMC article.
Developmental exposure to TBT has been shown to cause fatty liver disease (steatosis), as well as increased adiposity in many species, leading to its characterization as an obesogen. OBJECTIVE: We aimed to determine the long-term effects of developmental TBT exposure on th …
Developmental exposure to TBT has been shown to cause fatty liver disease (steatosis), as well as increased adiposity in many species, leadi …
Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome.
Adams JM, Huppert KA, Castro EC, Lopez MF, Niknejad N, Subramanian S, Zarrin-Khameh N, Finegold MJ, Huppert SS, Jafar-Nejad H. Adams JM, et al. Among authors: finegold mj. Hepatology. 2020 Apr;71(4):1331-1349. doi: 10.1002/hep.30912. Epub 2020 Jan 24. Hepatology. 2020. PMID: 31469182 Free PMC article.
Notably, Sox9 overexpression improves BD paucity and liver phenotypes in Jag1(+/-) mice without ectopic hepatocyte-to-cholangiocyte transdifferentiation or long-term liver abnormalities. Notch2 expression in the liver is increased following Sox9 overexpression, and SOX9 bi …
Notably, Sox9 overexpression improves BD paucity and liver phenotypes in Jag1(+/-) mice without ectopic hepatocyte-to-cholangiocyte transdif …
Hepatic Steatosis Is Prevalent Following Orthotopic Liver Transplantation in Children With Cystic Fibrosis.
Cortes-Santiago N, Leung DH, Castro E, Finegold M, Wu H, Patel KR. Cortes-Santiago N, et al. Among authors: finegold m. J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):96-103. doi: 10.1097/MPG.0000000000002154. J Pediatr Gastroenterol Nutr. 2019. PMID: 30234762
Our findings suggest that allograft steatosis in patients with CF may be related to pre-existing steatosis in native livers, regardless of other risk factors and may have implications on patient management and long-term graft/patient survival....
Our findings suggest that allograft steatosis in patients with CF may be related to pre-existing steatosis in native livers, regardless of o …
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.
Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Shneider BL, et al. J Pediatr. 2016 Mar;170:211-7.e1-2. doi: 10.1016/j.jpeds.2015.11.058. Epub 2015 Dec 24. J Pediatr. 2016. PMID: 26725209 Free PMC article.
Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium.
Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ; Childhood Liver Disease Research and Education Network (CHiLDREN). Ng VL, et al. J Pediatr. 2014 Sep;165(3):539-546.e2. doi: 10.1016/j.jpeds.2014.05.038. Epub 2014 Jul 9. J Pediatr. 2014. PMID: 25015575 Free PMC article.
Individual tests of liver synthetic function (total bilirubin, albumin, and international normalized ratio) were normal in 75%, 85%, and 73% of the study cohort. CONCLUSION: Cholangitis and fractures in long-term survivors underscore the importance of ongoing medical surve …
Individual tests of liver synthetic function (total bilirubin, albumin, and international normalized ratio) were normal in 75%, 85%, and 73% …
Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors.
Brunetti-Pierri N, Ng T, Iannitti D, Cioffi W, Stapleton G, Law M, Breinholt J, Palmer D, Grove N, Rice K, Bauer C, Finegold M, Beaudet A, Mullins C, Ng P. Brunetti-Pierri N, et al. Among authors: finegold m. Hum Gene Ther. 2013 Aug;24(8):761-5. doi: 10.1089/hum.2013.071. Hum Gene Ther. 2013. PMID: 23902403 Free PMC article.
We have previously shown that transgene expression from HDAd-transduced hepatocytes can persist at high levels for up to 2.6 years in nonhuman primates following a single-vector administration. Because duration of transgene expression and long-term toxicity are critical fo …
We have previously shown that transgene expression from HDAd-transduced hepatocytes can persist at high levels for up to 2.6 years in nonhum …
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H. Huch M, et al. Among authors: finegold mj. Nature. 2013 Feb 14;494(7436):247-50. doi: 10.1038/nature11826. Epub 2013 Jan 27. Nature. 2013. PMID: 23354049 Free PMC article.
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term …
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, sel …
Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques.
Brunetti-Pierri N, Liou A, Patel P, Palmer D, Grove N, Finegold M, Piccolo P, Donnachie E, Rice K, Beaudet A, Mullins C, Ng P. Brunetti-Pierri N, et al. Among authors: finegold m. Mol Ther. 2012 Oct;20(10):1863-70. doi: 10.1038/mt.2012.143. Epub 2012 Jul 24. Mol Ther. 2012. PMID: 22828499 Free PMC article.
Hemophilia B is an excellent candidate for gene therapy because low levels of factor IX (FIX) (1%) result in clinically significant improvement of the bleeding diathesis. Helper-dependent adenoviral (HDAd) vectors can mediate long-term transgene expression without chronic …
Hemophilia B is an excellent candidate for gene therapy because low levels of factor IX (FIX) (1%) result in clinically significant improvem …
44 results