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Intranasal administration of CNS therapeutics to awake mice.
Hanson LR, Fine JM, Svitak AL, Faltesek KA. Hanson LR, et al. Among authors: fine jm. J Vis Exp. 2013 Apr 8;(74):4440. doi: 10.3791/4440. J Vis Exp. 2013. PMID: 23608783 Free PMC article.
With mice, it is possible to administer drugs to awake (non-anesthetized) animals on a regular basis using a specialized intranasal grip. Awake delivery is beneficial because it allows for long-term chronic dosing without anesthesia, it takes less time than with anesthesia …
With mice, it is possible to administer drugs to awake (non-anesthetized) animals on a regular basis using a specialized intranasal grip. Aw …
Lung function is unchanged in the 1 G environment following 6-months exposure to microgravity.
Prisk GK, Fine JM, Cooper TK, West JB. Prisk GK, et al. Among authors: fine jm. Eur J Appl Physiol. 2008 Aug;103(6):617-23. doi: 10.1007/s00421-008-0754-2. Epub 2008 May 7. Eur J Appl Physiol. 2008. PMID: 18481079
These results suggest that unlike many other organ systems in the human body, lung function returns to normal after long term exposure to the removal of gravity. We conclude that that in a normoxic, normobaric environment, lung function is not a concern following long-dura …
These results suggest that unlike many other organ systems in the human body, lung function returns to normal after long term exposur …
Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia.
Aujesky D, Auble TE, Yealy DM, Stone RA, Obrosky DS, Meehan TP, Graff LG, Fine JM, Fine MJ. Aujesky D, et al. Among authors: fine jm. Am J Med. 2005 Apr;118(4):384-92. doi: 10.1016/j.amjmed.2005.01.006. Am J Med. 2005. PMID: 15808136
CONCLUSIONS: The more complex Pneumonia Severity Index has a higher discriminatory power for short-term mortality, defines a greater proportion of patients at low risk, and is slightly more accurate in identifying patients at low risk than either CURB score....
CONCLUSIONS: The more complex Pneumonia Severity Index has a higher discriminatory power for short-term mortality, defines a greater …
Sodium depletion prevents albuminuria in hypertensive rats.
Jyothirmayi GN, Alluru L, Fine JM, Reddi AS. Jyothirmayi GN, et al. Among authors: fine jm. Res Commun Mol Pathol Pharmacol. 1995 Oct;90(1):115-24. Res Commun Mol Pathol Pharmacol. 1995. PMID: 8581336
The effect of short term (8 weeks) sodium (Na+) depletion and its repletion on glomerular synthesis of heparan sulfate and urinary excretions of albumin, total protein, heparan sulfate, Na+ and potassium (K+) was studied in spontaneous hypertensive rats (SHR) and their con …
The effect of short term (8 weeks) sodium (Na+) depletion and its repletion on glomerular synthesis of heparan sulfate and urinary ex …
Metal fume fever.
Gordon T, Fine JM. Gordon T, et al. Among authors: fine jm. Occup Med. 1993 Jul-Sep;8(3):504-17. Occup Med. 1993. PMID: 8272976 Review.
Nonetheless, as any worker who has experienced a full-blown case will likely testify, metal fume fever remains one of the more noxious short-term illnesses contracted in the workplace, and its prevention deserves serious attention....
Nonetheless, as any worker who has experienced a full-blown case will likely testify, metal fume fever remains one of the more noxious short …