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Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.
Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C. Altafaj X, et al. Among authors: fillat c. Neurobiol Dis. 2013 Apr;52:117-27. doi: 10.1016/j.nbd.2012.11.017. Epub 2012 Dec 5. Neurobiol Dis. 2013. PMID: 23220201
In contrast, contralateral hippocampal injection with an AAV2/1 control virus containing a scrambled sequence, showed neither the normalization of Dyrk1A levels nor changes of synaptic plasticity. In the Morris water maze task, although long-term consolidation of the task …
In contrast, contralateral hippocampal injection with an AAV2/1 control virus containing a scrambled sequence, showed neither the normalizat …
Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
Dierssen M, Arqué G, McDonald J, Andreu N, Martínez-Cué C, Flórez J, Fillat C. Dierssen M, et al. Among authors: fillat c. PLoS One. 2011 Feb 25;6(2):e17010. doi: 10.1371/journal.pone.0017010. PLoS One. 2011. PMID: 21364922 Free PMC article.
However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down passive avoidance task, thus suggesting that once learning has been established, the animals are able to consolidate the information in the lo …
However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down pa …
Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.
Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sánchez P, Arbonés ML, Fariñas I. Ferron SR, et al. Among authors: fillat c. Cell Stem Cell. 2010 Sep 3;7(3):367-79. doi: 10.1016/j.stem.2010.06.021. Cell Stem Cell. 2010. PMID: 20804972 Free article.
Finally, Dyrk1a heterozygous NSCs exhibit defects in self-renewal, EGF-dependent cell-fate decisions, and long-term persistence in vivo, suggesting that symmetrical divisions play a role in the maintenance of the SEZ reservoir....
Finally, Dyrk1a heterozygous NSCs exhibit defects in self-renewal, EGF-dependent cell-fate decisions, and long-term persistence in vi …
X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options.
Albert MH, Bittner TC, Nonoyama S, Notarangelo LD, Burns S, Imai K, Espanol T, Fasth A, Pellier I, Strauss G, Morio T, Gathmann B, Noordzij JG, Fillat C, Hoenig M, Nathrath M, Meindl A, Pagel P, Wintergerst U, Fischer A, Thrasher AJ, Belohradsky BH, Ochs HD. Albert MH, et al. Among authors: fillat c. Blood. 2010 Apr 22;115(16):3231-8. doi: 10.1182/blood-2009-09-239087. Epub 2010 Feb 19. Blood. 2010. PMID: 20173115 Free article.
This analysis of the clinical outcome and molecular basis of patients with XLT shows excellent long-term survival but also a high probability of severe disease-related complications. ...
This analysis of the clinical outcome and molecular basis of patients with XLT shows excellent long-term survival but also a high pro …
Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.
Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. Ortiz-Abalia J, et al. Among authors: fillat c. Am J Hum Genet. 2008 Oct;83(4):479-88. doi: 10.1016/j.ajhg.2008.09.010. Am J Hum Genet. 2008. PMID: 18940310 Free PMC article.
Injecting the vector into the striata of TgDyrk1A mice resulted in a restricted, long-term transduction of the striatum. This gene therapy was found to be devoid of toxicity and succeeded in normalizing Dyrk1A protein levels in TgDyrk1A mice. ...
Injecting the vector into the striata of TgDyrk1A mice resulted in a restricted, long-term transduction of the striatum. This gene th …
Direct electrotransfer of hHGF gene into kidney ameliorates ischemic acute renal failure.
Franquesa M, Alperovich G, Herrero-Fresneda I, Lloberas N, Bolaños N, Fillat C, Rama I, Cruzado JM, Grinyó JM, Torras J. Franquesa M, et al. Among authors: fillat c. Gene Ther. 2005 Nov;12(21):1551-8. doi: 10.1038/sj.gt.3302569. Gene Ther. 2005. PMID: 15973441
ARF in the context of renal transplantation predisposes the graft to developing chronic damage and to long-term graft loss. Hepatocyte growth factor (HGF) has been suggested to support the intrinsic ability of the kidney to regenerate in response to injury by its morphogen …
ARF in the context of renal transplantation predisposes the graft to developing chronic damage and to long-term graft loss. Hepatocyt …
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy.
Carrió M, Mazo A, López-Iglesias C, Estivill X, Fillat C. Carrió M, et al. Among authors: fillat c. Int J Cancer. 2001 Oct 1;94(1):81-8. doi: 10.1002/ijc.1429. Int J Cancer. 2001. PMID: 11668482 Free article.
The bystander effect in NP-18 Cx26 cells was also prevented by the long term inhibitor of GJIC, 18-alpha-glycyrrhetinic acid (AGA). Together, these results demonstrate that pancreatic tumor cells are highly different as regards the susceptibility to HSV-tk/GCV treatment. . …
The bystander effect in NP-18 Cx26 cells was also prevented by the long term inhibitor of GJIC, 18-alpha-glycyrrhetinic acid (AGA). T …