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Quantitative label-free mass spectrometry reveals content and signaling differences between neonatal and adult platelets.
Thom CS, Davenport P, Fazelinia H, Soule-Albridge E, Liu ZJ, Zhang H, Feldman HA, Ding H, Roof J, Spruce LA, Ischiropoulos H, Sola-Visner M. Thom CS, et al. Among authors: feldman ha. J Thromb Haemost. 2024 May;22(5):1447-1462. doi: 10.1016/j.jtha.2023.12.022. Epub 2023 Dec 30. J Thromb Haemost. 2024. PMID: 38160730
METHODS: We isolated resting umbilical cord blood-derived platelets from healthy full-term neonates (n = 8) and resting blood platelets from healthy adults (n = 6) and compared protein and phosphoprotein contents using data-independent acquisition mass spectrometry. ...
METHODS: We isolated resting umbilical cord blood-derived platelets from healthy full-term neonates (n = 8) and resting blood platele …
Negativity begets longevity in T cells.
Feldman HA, Cevik H, Waggoner SN. Feldman HA, et al. J Clin Invest. 2023 Jun 15;133(12):e171027. doi: 10.1172/JCI171027. J Clin Invest. 2023. PMID: 37317967 Free PMC article.
This effect was independent of direct signals provided to KIR-expressing T cells and was instead driven by indirect mechanisms. Since the long-term maintenance of CD8+ T cells is critical for immune readiness against cancer and infection, this discovery has implications fo …
This effect was independent of direct signals provided to KIR-expressing T cells and was instead driven by indirect mechanisms. Since the lo …
Surgical Approach and Persistent Opioid Use in Medicare Patients Undergoing Lung Cancer Resection.
Zhou N, Niu J, Nelson D, Feldman HA, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG, Walsh GL, Giordano SH, Rajaram R. Zhou N, et al. Among authors: feldman ha. Ann Thorac Surg. 2023 Nov;116(5):1020-1027. doi: 10.1016/j.athoracsur.2023.02.013. Epub 2023 Feb 16. Ann Thorac Surg. 2023. PMID: 36801207
Both robotic and VATS approaches were associated with decreased persistent opioid use compared with open surgery among opioid naive patients. Whether a robotic approach yields additional long-term advantages over VATS warrants further investigation....
Both robotic and VATS approaches were associated with decreased persistent opioid use compared with open surgery among opioid naive patients …
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty.
Zhu J, Liu E, Feld A, Jonsdottir-Lewis E, Shirey A, Feldman HA, Astley CM, Chan YM. Zhu J, et al. Among authors: feldman ha. Horm Res Paediatr. 2023;96(3):267-277. doi: 10.1159/000526590. Epub 2022 Aug 25. Horm Res Paediatr. 2023. PMID: 36007499 Free PMC article.
Dissecting self-limited DP into its component subtypes may inform future studies of the mechanisms contributing to pubertal delay as well as studies of the short- and long-term outcomes of self-limited DP....
Dissecting self-limited DP into its component subtypes may inform future studies of the mechanisms contributing to pubertal delay as well as …
Salvage Esophagectomy Definition Influences Comparative Outcomes in Esophageal Squamous Cell Cancers.
Zhou N, Hofstetter WL; Esophageal Squamous Cell Carcinoma Working Group; Mitchell KG, Bayley EM, Ajani JA, Antonoff MB, Betancourt SL, Blum-Murphy M, Feldman HA, Lin SH, Maru DM, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Weston BR. Zhou N, et al. Among authors: feldman ha. Ann Thorac Surg. 2022 Dec;114(6):2032-2040. doi: 10.1016/j.athoracsur.2021.10.046. Epub 2021 Dec 6. Ann Thorac Surg. 2022. PMID: 34883083
BMT included patients treated with CRT only plus salvage esophagectomy, variably defined as an esophagectomy occurring (A) 3 months after CRT; (B) 3 months after CRT, excluding delayed recovery; (C) 3 months after CRT, excluding delayed workup; or (D) 6 months after CRT. Long- …
BMT included patients treated with CRT only plus salvage esophagectomy, variably defined as an esophagectomy occurring (A) 3 months after CR …
Dose- and sex-dependent effects of phlebotomy-induced anemia on the neonatal mouse hippocampal transcriptome.
Singh G, Wallin DJ, Abrahante Lloréns JE, Tran PV, Feldman HA, Georgieff MK, Gisslen T. Singh G, et al. Among authors: feldman ha. Pediatr Res. 2022 Sep;92(3):712-720. doi: 10.1038/s41390-021-01832-9. Epub 2021 Nov 13. Pediatr Res. 2022. PMID: 34775474 Free PMC article.
In mice, PIA causes brain tissue hypoxia, iron deficiency, and long-term sex-dependent neurobehavioral abnormalities. The neuroregulatory molecular pathways disrupted by PIA underlying these effects are unknown. ...Such changes may also result from other causes of neonatal …
In mice, PIA causes brain tissue hypoxia, iron deficiency, and long-term sex-dependent neurobehavioral abnormalities. The neuroregula …
Longitudinal structural connectomic and rich-club analysis in adolescent mTBI reveals persistent, distributed brain alterations acutely through to one year post-injury.
Chung AW, Mannix R, Feldman HA, Grant PE, Im K. Chung AW, et al. Among authors: feldman ha. Sci Rep. 2019 Dec 11;9(1):18833. doi: 10.1038/s41598-019-54950-0. Sci Rep. 2019. PMID: 31827105 Free PMC article.
The diffuse nature of mild traumatic brain injury (mTBI) impacts brain white-matter pathways with potentially long-term consequences, even after initial symptoms have resolved. To understand post-mTBI recovery in adolescents, longitudinal studies are needed to determine th …
The diffuse nature of mild traumatic brain injury (mTBI) impacts brain white-matter pathways with potentially long-term consequences, …
A low cost, re-usable electricity-free infant warmer: evaluation of safety, effectiveness and feasibiliy.
Nahimana E, May L, Gadgil A, Rapp V, Magge H, Kubwimana M, Nshimyiryo A, Kateera F, Feldman HA, Nkikabahizi F, Sayinzoga F, Hansen A. Nahimana E, et al. Among authors: feldman ha. Public Health Action. 2018 Dec 21;8(4):211-217. doi: 10.5588/pha.18.0031. Public Health Action. 2018. PMID: 30775282 Free PMC article.
Setting: Rural Rwandan hospitals, where thermoregulation is critical yet a challenge for pre-term, low-birth-weight (LBW) or sick newborns. Objective: To assess the safety, effectiveness, and feasibility of an inexpensive, reusable, non-electric warmer to complement …
Setting: Rural Rwandan hospitals, where thermoregulation is critical yet a challenge for pre-term, low-birth-weight (LBW) or s …
Validity of Body Mass Index as a Measure of Adiposity in Infancy.
Bell KA, Wagner CL, Perng W, Feldman HA, Shypailo RJ, Belfort MB. Bell KA, et al. Among authors: feldman ha. J Pediatr. 2018 May;196:168-174.e1. doi: 10.1016/j.jpeds.2018.01.028. Epub 2018 Mar 15. J Pediatr. 2018. PMID: 29551311 Free PMC article.
OBJECTIVES: To assess the validity of body mass index (BMI) and age- and sex-standardized BMI z-score (BMIZ) as surrogates for adiposity (body fat percentage [BF%], fat mass, and fat mass index [kg/m(2)]) at 3 time points in infancy (1, 4, and 7 months) and to assess the extent t …
OBJECTIVES: To assess the validity of body mass index (BMI) and age- and sex-standardized BMI z-score (BMIZ) as surrogates for adiposity (bo …
A randomized study of dietary composition during weight-loss maintenance: Rationale, study design, intervention, and assessment.
Ebbeling CB, Klein GL, Luoto PK, Wong JMW, Bielak L, Eddy RG, Steltz SK, Devlin C, Sandman M, Hron B, Shimy K, Heymsfield SB, Wolfe RR, Wong WW, Feldman HA, Ludwig DS. Ebbeling CB, et al. Among authors: feldman ha. Contemp Clin Trials. 2018 Feb;65:76-86. doi: 10.1016/j.cct.2017.12.004. Epub 2017 Dec 9. Contemp Clin Trials. 2018. PMID: 29233719 Free PMC article.
BACKGROUND: While many people with overweight or obesity can lose weight temporarily, most have difficulty maintaining weight loss over the long term. Studies of dietary composition typically focus on weight loss, rather than weight-loss maintenance, and rely on nutrition …
BACKGROUND: While many people with overweight or obesity can lose weight temporarily, most have difficulty maintaining weight loss over the …
26 results