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Oral and Injectable (Non-Insulin) Pharmacological Agents for the Treatment of Type 2 Diabetes.
Feingold KR. Feingold KR. 2022 Aug 26. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2022 Aug 26. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905364 Free Books & Documents. Review.
While lifestyle changes such as dietary modification and increased physical activity can be very effective in improving glycemic control, over the long-term most individuals with Type 2 diabetes (T2DM) will require medications to achieve and maintain glycemic control. ...
While lifestyle changes such as dietary modification and increased physical activity can be very effective in improving glycemic control, ov …
Effect of inflammation on HDL structure and function.
Feingold KR, Grunfeld C. Feingold KR, et al. Curr Opin Lipidol. 2016 Oct;27(5):521-30. doi: 10.1097/MOL.0000000000000333. Curr Opin Lipidol. 2016. PMID: 27495134 Review.
SUMMARY: During inflammation multiple changes in HDL structure occur leading to alterations in HDL function. In the short term, these changes may be beneficial resulting in an increase in cholesterol in peripheral cells to improve host defense and repair but over the long …
SUMMARY: During inflammation multiple changes in HDL structure occur leading to alterations in HDL function. In the short term, these …
Regulation of ABCA1 expression in human keratinocytes and murine epidermis.
Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR. Jiang YJ, et al. Among authors: feingold kr. J Lipid Res. 2006 Oct;47(10):2248-58. doi: 10.1194/jlr.M600163-JLR200. Epub 2006 Jul 6. J Lipid Res. 2006. PMID: 16825673 Free article.
In addition, during fetal epidermal development, ABCA1 expression decreases at days 18-22 of gestation (term = 22 days), leaving more cholesterol available during the critical period of barrier formation. ...
In addition, during fetal epidermal development, ABCA1 expression decreases at days 18-22 of gestation (term = 22 days), leaving more …
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.
Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM. Hachem JP, et al. Among authors: feingold kr. J Invest Dermatol. 2005 Sep;125(3):510-20. doi: 10.1111/j.0022-202X.2005.23838.x. J Invest Dermatol. 2005. PMID: 16117792 Free article.
We showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in permeability barrier homeostasis and SC integrity/cohesion. Since prolonged SC neutralization more closely mirrors clinical situations (i.e., neonatal skin, occu …
We showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in permeability barrier …
Is endogenous glycerol a determinant of stratum corneum hydration in humans?
Choi EH, Man MQ, Wang F, Zhang X, Brown BE, Feingold KR, Elias PM. Choi EH, et al. Among authors: feingold kr. J Invest Dermatol. 2005 Aug;125(2):288-93. doi: 10.1111/j.0022-202X.2005.23799.x. J Invest Dermatol. 2005. PMID: 16098039 Free article.
SC hydration is also linked to SC glycerol content in SG-impoverished sites, suggesting a role for non-SG-derived (? from circulation) glycerol in SC hydration. Finally, short-term water immersion produces a parallel decline in SC hydration and SC glycerol content, with gl …
SC hydration is also linked to SC glycerol content in SG-impoverished sites, suggesting a role for non-SG-derived (? from circulation) glyce …
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.
Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, Ahn SK, Brown BE, Elias PM, Feingold KR. Kao JS, et al. Among authors: feingold kr. J Invest Dermatol. 2003 Mar;120(3):456-64. doi: 10.1046/j.1523-1747.2003.12053.x. J Invest Dermatol. 2003. PMID: 12603860 Free article.
Prolonged exposure of human epidermis to excess endogenous or exogenous glucocorticoids can result in well-recognized cutaneous abnormalities. Here, we determined whether short-term glucocorticoid treatment would also display adverse effects, specifically on two key epider …
Prolonged exposure of human epidermis to excess endogenous or exogenous glucocorticoids can result in well-recognized cutaneous abnormalitie …
Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis.
Sato J, Denda M, Chang S, Elias PM, Feingold KR. Sato J, et al. Among authors: feingold kr. J Invest Dermatol. 2002 Oct;119(4):900-4. doi: 10.1046/j.1523-1747.2002.00589.x. J Invest Dermatol. 2002. PMID: 12406336 Free article.
Previous reports demonstrated that long-term exposure to extremes in humidity influence permeability barrier homeostasis. ...
Previous reports demonstrated that long-term exposure to extremes in humidity influence permeability barrier homeostasis. ...
Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity.
Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM. Fluhr JW, et al. Among authors: feingold kr. J Invest Dermatol. 2001 Jul;117(1):44-51. doi: 10.1046/j.0022-202x.2001.01399.x. J Invest Dermatol. 2001. PMID: 11442748 Free article.
Moreover, exposure of intact murine stratum corneum to a neutral pH for as little as 3 h produced comparable abnormalities in stratum corneum integrity and cohesion, and further amplified the inhibitor-induced functional alterations. Furthermore, short-term applications of …
Moreover, exposure of intact murine stratum corneum to a neutral pH for as little as 3 h produced comparable abnormalities in stratum corneu …
Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse.
Hanley K, Feingold KR, Kömüves LG, Elias PM, Muglia LJ, Majzoub JA, Williams ML. Hanley K, et al. Among authors: feingold kr. J Invest Dermatol. 1998 Sep;111(3):440-4. doi: 10.1046/j.1523-1747.1998.00303.x. J Invest Dermatol. 1998. PMID: 9740238 Free article.
To determine whether glucocorticoids are required for normal SC maturation, we examined the epidermal morphology of glucocorticoid-deficient (C-) murine pups, derived from matings of mice homozygous for null mutations of the corticotropin-releasing hormone alleles. In control pup …
To determine whether glucocorticoids are required for normal SC maturation, we examined the epidermal morphology of glucocorticoid-deficient …
Hypothyroidism delays fetal stratum corneum development in mice.
Hanley K, Devaskar UP, Hicks SJ, Jiang Y, Crumrine D, Elias PM, Williams ML, Feingold KR. Hanley K, et al. Among authors: feingold kr. Pediatr Res. 1997 Nov;42(5):610-4. doi: 10.1203/00006450-199711000-00010. Pediatr Res. 1997. PMID: 9357932
Here we studied SC development in Hyt/Hyt mice who are genetically hypothyroid due to a mutation in the TSH receptor. In control mice on d 18 of gestation (term 19.5 d), only focal areas displayed a mature SC membrane pattern. ...In Hyt/Hyt mice SC development was delayed …
Here we studied SC development in Hyt/Hyt mice who are genetically hypothyroid due to a mutation in the TSH receptor. In control mice on d 1 …
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