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Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis.
Cabrera D, Gutiérrez J, Cabello-Verrugio C, Morales MG, Mezzano S, Fadic R, Casar JC, Hancke JL, Brandan E. Cabrera D, et al. Among authors: fadic r. Skelet Muscle. 2014 Mar 21;4:6. doi: 10.1186/2044-5040-4-6. eCollection 2014. Skelet Muscle. 2014. PMID: 24655808 Free PMC article.
These drugs prolong muscle strength and ambulation of patients for a short term only and have severe adverse effects. Andrographolide, a bicyclic diterpenoid lactone, has traditionally been used for the treatment of colds, fever, laryngitis, and other infections with no or …
These drugs prolong muscle strength and ambulation of patients for a short term only and have severe adverse effects. Andrographolide …
[Stem cells therapy in amyotrophic lateral sclerosis treatment. A critical view].
Soler B, Fadic R, von Bernhardi R. Soler B, et al. Among authors: fadic r. Rev Neurol. 2011 Apr 1;52(7):426-34. Rev Neurol. 2011. PMID: 21425112 Free article. Review. Spanish.
CONCLUSION: Additional preclinical studies are necessary to refine this therapeutic approach, to assess long term survival and differentiation of mesenchymal stem cells, dosing, biological activity and safety should be conducted before any planning further human testing oc …
CONCLUSION: Additional preclinical studies are necessary to refine this therapeutic approach, to assess long term survival and differ …
Muscle pathology and clinical features of the sarcolemmopathies.
Fadic R, Waclawik AJ, Lewandoski PJ, Lotz BP. Fadic R, et al. Pediatr Neurol. 1997 Jan;16(1):79-82. doi: 10.1016/s0887-8994(96)00265-2. Pediatr Neurol. 1997. PMID: 9044410
., a structural weakening of the sarcolemma with an increased susceptibility to rupture under mechanical stress. We propose the term sarcolemmopathy as an all-encompassing rubric for these disorders....
., a structural weakening of the sarcolemma with an increased susceptibility to rupture under mechanical stress. We propose the term …