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2012 2
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2014 2
2015 3
2016 1
2024 0

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A long-term follow-up of patients with prolonged asystole of greater than 15s on head-up tilt testing.
Sau A, Mereu R, Taraborrelli P, Dhutia NM, Willson K, Hayat SA, Francis DP, Sutton R, Lim PB. Sau A, et al. Int J Cardiol. 2016 Jan 15;203:482-5. doi: 10.1016/j.ijcard.2015.10.090. Epub 2015 Oct 21. Int J Cardiol. 2016. PMID: 26547742 Free article.
VVS is usually considered benign, however pacemaker insertion may be indicated in some patients. We sought to characterize the long-term outcomes of patients with prolonged asystole (>15s) on HUT. ...CONCLUSIONS: Prolonged asystole (>15s) on tilt does not necessarily …
VVS is usually considered benign, however pacemaker insertion may be indicated in some patients. We sought to characterize the long-term …
The effect of duration of follow-up and presence of competing risk on lifespan-gain from implantable cardioverter defibrillator therapy: who benefits the most?
Raphael CE, Finegold JA, Barron AJ, Whinnett ZI, Mayet J, Linde C, Cleland JG, Levy WC, Francis DP. Raphael CE, et al. Eur Heart J. 2015 Jul 7;36(26):1676-88. doi: 10.1093/eurheartj/ehv102. Epub 2015 Apr 23. Eur Heart J. 2015. PMID: 25908776
CONCLUSION: While high-risk patients may show the greatest short-term gain, the dramatic growth of lifespan-gain over time means that it is the lower risk patients, e.g. primary prevention ICD implantation, who gain the most life-years over their lifetime. ...
CONCLUSION: While high-risk patients may show the greatest short-term gain, the dramatic growth of lifespan-gain over time means that …
Non-randomised comparison of acute and long-term outcomes of robotic versus manual ventricular tachycardia ablation in a single centre ischemic cohort.
Luther V, Jamil-Copley S, Koa-Wing M, Shun-Shin M, Hayat S, Linton NW, Lim PB, Whinnett Z, Wright IJ, Lefroy D, Peters NS, Davies DW, Kanagaratnam P. Luther V, et al. J Interv Card Electrophysiol. 2015 Aug;43(2):175-85. doi: 10.1007/s10840-015-9992-5. Epub 2015 Apr 11. J Interv Card Electrophysiol. 2015. PMID: 25862557 Free article.
Therapy burden fell from 14 (10-25) to 1 (0-5) (p = 0.023) in the manual group. There was no difference in long-term outcome (p = 0.60) and mortality (4/12 (33%), p = 1.0). CONCLUSION: Robotically guided VT ablation is both feasible and safe when compared to manual ablatio …
Therapy burden fell from 14 (10-25) to 1 (0-5) (p = 0.023) in the manual group. There was no difference in long-term outcome (p = 0.6 …
Unintentional overestimation of an expected antihypertensive effect in drug and device trials: mechanisms and solutions.
Howard JP, Cole GD, Sievert H, Bhatt DL, Papademetriou V, Kandzari DE, Davies JE, Francis DP. Howard JP, et al. Int J Cardiol. 2014 Mar 1;172(1):29-35. doi: 10.1016/j.ijcard.2013.12.183. Epub 2014 Jan 8. Int J Cardiol. 2014. PMID: 24480181 Review.
A 10-mmHg reduction, without needing to adhere to an extra drug, would still substantially reduce events in the long term, but crucial to such reasoning is the reliable quantification of the blood pressure effect, free of bias....
A 10-mmHg reduction, without needing to adhere to an extra drug, would still substantially reduce events in the long term, but crucia …
Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias.
Jamil-Copley S, Bokan R, Kojodjojo P, Qureshi N, Koa-Wing M, Hayat S, Kyriacou A, Sandler B, Sohaib A, Wright I, Davies DW, Whinnett Z, S Peters N, Kanagaratnam P, Lim PB. Jamil-Copley S, et al. Heart Rhythm. 2014 Apr;11(4):587-94. doi: 10.1016/j.hrthm.2014.01.013. Epub 2014 Jan 17. Heart Rhythm. 2014. PMID: 24440381 Free PMC article.
Acute success was defined as abolition of ectopy after ablation. Medium-term success was defined as the abolition of symptoms and reduction of PVC to less than 1000 per day documented on Holter monitoring within 6 months. ...Acute ablation success was achieved in 100% of t …
Acute success was defined as abolition of ectopy after ablation. Medium-term success was defined as the abolition of symptoms and red …
Cardiac resynchronisation therapy optimisation strategies: systematic classification, detailed analysis, minimum standards and a roadmap for development and testing.
International Working Group on Quantitative Optimization:; Sohaib SM, Whinnett ZI, Ellenbogen KA, Stellbrink C, Quinn TA, Bogaard MD, Bordachar P, van Gelder BM, van Geldorp IE, Linde C, Meine M, Prinzen FW, Turcott RG, Spotnitz HM, Wichterle D, Francis DP. International Working Group on Quantitative Optimization:, et al. Int J Cardiol. 2013 Dec 10;170(2):118-31. doi: 10.1016/j.ijcard.2013.10.069. Epub 2013 Oct 29. Int J Cardiol. 2013. PMID: 24239155 Review.
Expectation of a sophisticated enquiry from the clinical community will encourage optimisation protocol-designers to focus on testing early (and cheaply) the basic properties that are vital for any chance of long term efficacy....
Expectation of a sophisticated enquiry from the clinical community will encourage optimisation protocol-designers to focus on testing early …
International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension.
Schlaich MP, Schmieder RE, Bakris G, Blankestijn PJ, Böhm M, Campese VM, Francis DP, Grassi G, Hering D, Katholi R, Kjeldsen S, Krum H, Mahfoud F, Mancia G, Messerli FH, Narkiewicz K, Parati G, Rocha-Singh KJ, Ruilope LM, Rump LC, Sica DA, Sobotka PA, Tsioufis C, Vonend O, Weber MA, Williams B, Zeller T, Esler MD. Schlaich MP, et al. J Am Coll Cardiol. 2013 Dec 3;62(22):2031-45. doi: 10.1016/j.jacc.2013.08.1616. Epub 2013 Sep 18. J Am Coll Cardiol. 2013. PMID: 24021387 Free article.
Optimal periprocedural management of volume status and medication regimens at specialized and experienced centers equipped with adequate infrastructure to cope with potential procedural complications will minimize potential patient risks. Long-term safety and efficacy data …
Optimal periprocedural management of volume status and medication regimens at specialized and experienced centers equipped with adequate inf …
Fully automatable, reproducible, noninvasive simple plethysmographic optimization: proof of concept and potential for implantability.
Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegemann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DP. Kyriacou A, et al. Pacing Clin Electrophysiol. 2012 Aug;35(8):948-60. doi: 10.1111/j.1540-8159.2012.03435.x. Epub 2012 Jul 2. Pacing Clin Electrophysiol. 2012. PMID: 22747698 Clinical Trial.
METHOD: Twenty patients (age 65 12) with CRT underwent automatic atrioventricular (AV) delay optimization, using a multiple-transitions protocol, at two atrially paced heart rates: just above sinus rate ("slow ApVp," 77 11 beats per minute [bpm]) and 100 bpm ("fast ApVp"). We the …
METHOD: Twenty patients (age 65 12) with CRT underwent automatic atrioventricular (AV) delay optimization, using a multiple-transitions prot …
Cardiac resynchronization therapy is certainly cardiac therapy, but how much resynchronization and how much atrioventricular delay optimization?
Kyriacou A, Pabari PA, Francis DP. Kyriacou A, et al. Heart Fail Rev. 2012 Nov;17(6):727-36. doi: 10.1007/s10741-011-9271-1. Heart Fail Rev. 2012. PMID: 21796453 Free PMC article. Review.
Unless there is some other heretofore unrecognized effect of pacing, the benefits of atrio-biventricular pacing on hard outcomes observed in randomized trials can only be attributed to the physiological changes it induces such as increases in cardiac output and/or reduction in my …
Unless there is some other heretofore unrecognized effect of pacing, the benefits of atrio-biventricular pacing on hard outcomes observed in …