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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Cohen HY, et al. Science. 2004 Jul 16;305(5682):390-2. doi: 10.1126/science.1099196. Epub 2004 Jun 17. Science. 2004. PMID: 15205477
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
Small RNA: can RNA interference be exploited for therapy?
Wall NR, Shi Y. Wall NR, et al. Lancet. 2003 Oct 25;362(9393):1401-3. doi: 10.1016/S0140-6736(03)14637-5. Lancet. 2003. PMID: 14585643 Review.
Combined with genomics data, RNAi-directed gene-silencing could allow functional determination of any gene expressed in a cell or pathway. The term RNAi came from the discovery that the injection of dsRNAs into Caenorhabditis elegans interferes with the expression of speci …
Combined with genomics data, RNAi-directed gene-silencing could allow functional determination of any gene expressed in a cell or pathway. T …