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Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells.
Luna C, Li G, Qiu J, Challa P, Epstein DL, Gonzalez P. Luna C, et al. Among authors: epstein dl. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5805-10. doi: 10.1167/iovs.09-3796. Epub 2009 Jul 15. Invest Ophthalmol Vis Sci. 2009. PMID: 19608543 Free PMC article.
Addition of PGE2 (10 microM) to the media exerted cytoprotective effects against long-term CMS. CONCLUSIONS: Extracellular release of ATP induced by CMS in TM cells is mediated by exocytosis of ATP-enriched vesicles into lipid rafts. ...
Addition of PGE2 (10 microM) to the media exerted cytoprotective effects against long-term CMS. CONCLUSIONS: Extracellular release of …
Lentiviral mediated gene delivery to the anterior chamber of rodent eyes.
Challa P, Luna C, Liton PB, Chamblin B, Wakefield J, Ramabhadran R, Epstein DL, Gonzalez P. Challa P, et al. Among authors: epstein dl. Mol Vis. 2005 Jun 21;11:425-30. Mol Vis. 2005. PMID: 15988411 Free PMC article.
The EF-1alpha promoter induces high expression of the reporter gene and is a reliable alternative to the CMV promoter when stable, long term expression is desired....
The EF-1alpha promoter induces high expression of the reporter gene and is a reliable alternative to the CMV promoter when stable, long t …
Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments.
Borrás T, Rowlette LL, Tamm ER, Gottanka J, Epstein DL. Borrás T, et al. Among authors: epstein dl. Invest Ophthalmol Vis Sci. 2002 Jan;43(1):33-40. Invest Ophthalmol Vis Sci. 2002. PMID: 11773009
Percent change of facility from the baseline (C/C0) was computed at 6 and 24 hours and 2, 4, and 7 days from the long-term perfusion experiments (n = 9 h-IOP, n = 8 controls). RESULTS: No induction of TIGR/MYOC expression was observed after h-IOP for 1 and 6 h. ...
Percent change of facility from the baseline (C/C0) was computed at 6 and 24 hours and 2, 4, and 7 days from the long-term perfusion …
Isolation, culture, and characterization of endothelial cells from Schlemm's canal.
Stamer WD, Roberts BC, Howell DN, Epstein DL. Stamer WD, et al. Among authors: epstein dl. Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1804-12. Invest Ophthalmol Vis Sci. 1998. PMID: 9727403
Unlike TM cells, however, TIGR-MYOC protein was not induced in SC cells after long-term dexamethasone treatment. Schlemm's canal cells endocytosed low-density lipoprotein and acetylated low-density lipoprotein, and in the presence of Matrigel organized into multicellular t …
Unlike TM cells, however, TIGR-MYOC protein was not induced in SC cells after long-term dexamethasone treatment. Schlemm's canal cell …
Comparative study of the efficacy of argon laser trabeculoplasty for exfoliation and primary open-angle glaucoma.
Threlkeld AB, Hertzmark E, Sturm RT, Epstein DL, Allingham RR. Threlkeld AB, et al. Among authors: epstein dl. J Glaucoma. 1996 Oct;5(5):311-6. J Glaucoma. 1996. PMID: 8897230
Although the initial response to ALT in EXF patients is greater, the long-term outcome is similar for both groups....
Although the initial response to ALT in EXF patients is greater, the long-term outcome is similar for both groups....
Early treatment study of elevated intraocular pressure (2).
Epstein DL, Krug JH Jr, Hertzmark E, Remis LL, Edelstein DJ. Epstein DL, et al. J Glaucoma. 1993;2 Suppl A:3-4. J Glaucoma. 1993. PMID: 19920458
A randomized, long-term clinical trial was conducted to determine whether topical timolol therapy was effective in delaying or preventing the onset of glaucomatous damage in ocular hypertensive subjects. ...
A randomized, long-term clinical trial was conducted to determine whether topical timolol therapy was effective in delaying or preven …
The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma.
Melamed S, Kotas-Neumann R, Barak A, Epstein DL. Melamed S, et al. Among authors: epstein dl. Am J Ophthalmol. 1992 May 15;113(5):508-12. doi: 10.1016/s0002-9394(14)74721-x. Am J Ophthalmol. 1992. PMID: 1575224
Intracameral administration of ethacrynic acid or a derivative might be contemplated in the future at the time of other ocular surgical procedures to treat short-term intraocular pressure increase....
Intracameral administration of ethacrynic acid or a derivative might be contemplated in the future at the time of other ocular surgical proc …
Trabecular meshwork recovery after phagocytic challenge.
Johnson DH, Richardson TM, Epstein DL. Johnson DH, et al. Among authors: epstein dl. Curr Eye Res. 1989 Nov;8(11):1121-30. doi: 10.3109/02713688909000037. Curr Eye Res. 1989. PMID: 2612200
The short and long term response of the trabecular meshwork to a phagocytic challenge and the response of the meshwork to different types of foreign particles was studied by injecting one eye of 25 adult cats with a phagocytic agent (zymosan, blood, or latex microspheres) …
The short and long term response of the trabecular meshwork to a phagocytic challenge and the response of the meshwork to different t …
A clinical trial of timolol and epinephrine in the treatment of primary open-angle glaucoma.
Alexander DW, Berson FG, Epstein DL. Alexander DW, et al. Among authors: epstein dl. Ophthalmology. 1988 Feb;95(2):247-51. doi: 10.1016/s0161-6420(88)33205-7. Ophthalmology. 1988. PMID: 3050678 Clinical Trial.
Forty-seven patients with chronic open-angle glaucoma who required therapy but who had never been treated previously were enrolled in a prospective randomized, long-term clinical trial comparing the effectiveness of 0.5% timolol maleate and 1% epinephrine. ...The results s …
Forty-seven patients with chronic open-angle glaucoma who required therapy but who had never been treated previously were enrolled in a pros …
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