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Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).
Engel C, Rüdiger M, Benders MJNL, van Bel F, Allegaert K, Naulaers G, Bassler D, Klebermaß-Schrehof K, Vento M, Vilan A, Falck M, Mauro I, Metsäranta M, Vanhatalo S, Mazela J, Metsvaht T, van der Vlught R, Franz AR; ALBINO Study Group. Engel C, et al. Trials. 2024 Jan 24;25(1):81. doi: 10.1186/s13063-023-07828-6. Trials. 2024. PMID: 38267942 Free PMC article. Clinical Trial.
This ALBINO trial aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to (near-)term infants with early signs of HIE. METHODS/DESIGN: The ALBINO trial is an investigator-initiated, randomized, placebo-controlled, double-blind …
This ALBINO trial aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to (near-)term …
Long COVID symptoms in exposed and infected children, adolescents and their parents one year after SARS-CoV-2 infection: A prospective observational cohort study.
Haddad A, Janda A, Renk H, Stich M, Frieh P, Kaier K, Lohrmann F, Nieters A, Willems A, Huzly D, Dulovic A, Schneiderhan-Marra N, Jacobsen EM, Fabricius D, Zernickel M, Stamminger T, Bode SFN, Himpel T, Remppis J, Engel C, Peter A, Ganzenmueller T, Hoffmann GF, Haase B, Kräusslich HG, Müller B, Franz AR, Debatin KM, Tönshoff B, Henneke P, Elling R. Haddad A, et al. Among authors: engel c. EBioMedicine. 2022 Oct;84:104245. doi: 10.1016/j.ebiom.2022.104245. Epub 2022 Sep 22. EBioMedicine. 2022. PMID: 36155957 Free PMC article.
BACKGROUND: Long COVID in children and adolescents remains poorly understood due to a lack of well-controlled studies with long-term follow-up. In particular, the impact of the family context on persistent symptoms following SARS-CoV-2 infection remains unknown. ...
BACKGROUND: Long COVID in children and adolescents remains poorly understood due to a lack of well-controlled studies with long-term …
Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers.
Lammert J, Basrai M, Struck J, Hartmann O, Engel C, Bischoff SC, Berling-Ernst A, Halle M, Kiechle M, Grill S. Lammert J, et al. Among authors: engel c. Geburtshilfe Frauenheilkd. 2022 Jun 3;82(6):601-609. doi: 10.1055/a-1811-2164. eCollection 2022 Jun. Geburtshilfe Frauenheilkd. 2022. PMID: 35903716 Free PMC article.
Conclusions This is the first study in BRCA mutation carriers that has linked circulating ADM levels to traditional cardiovascular risk factors. The long-term clinical implications of these findings are yet to be determined....
Conclusions This is the first study in BRCA mutation carriers that has linked circulating ADM levels to traditional cardiovascular risk fact …
Neurological outcome in WDR62 primary microcephaly.
Ruaud L, Drunat S, Elmaleh-Bergès M, Ernault A, Guilmin Crepon S; MCPH Consortium; El Ghouzzi V, Auvin S, Verloes A, Passemard S. Ruaud L, et al. Dev Med Child Neurol. 2022 Apr;64(4):509-517. doi: 10.1111/dmcn.15060. Epub 2021 Sep 25. Dev Med Child Neurol. 2022. PMID: 35726608 Free article.
We identified progressive ataxia in the second decade of life in one patient, which should encourage clinicians to follow up patients in the long term....
We identified progressive ataxia in the second decade of life in one patient, which should encourage clinicians to follow up patients in the …
MRI-based brain volumes of preterm infants at term: a systematic review and meta-analysis.
Romberg J, Wilke M, Allgaier C, Nägele T, Engel C, Poets CF, Franz A. Romberg J, et al. Among authors: engel c. Arch Dis Child Fetal Neonatal Ed. 2022 Sep;107(5):520-526. doi: 10.1136/archdischild-2021-322846. Epub 2022 Jan 25. Arch Dis Child Fetal Neonatal Ed. 2022. PMID: 35078779 Free PMC article.
To date, there are no reference values for preterm infants' brain volumes at term-equivalent age. OBJECTIVE: Systematic review of the literature to determine reference ranges for MRI-based brain volumes of very preterm infants at term-equivalent age. METHODS: PubMed …
To date, there are no reference values for preterm infants' brain volumes at term-equivalent age. OBJECTIVE: Systematic review of the …
Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits.
Schrijver LH, Mooij TM, Pijpe A, Sonke GS, Mourits MJE, Andrieu N, Antoniou AC, Easton DF, Engel C, Goldgar D, John EM, Kast K, Milne RL, Olsson H, Phillips KA, Terry MB, Hopper JL, van Leeuwen FE, Rookus MA. Schrijver LH, et al. Among authors: engel c. J Natl Cancer Inst. 2022 Apr 11;114(4):540-552. doi: 10.1093/jnci/djac004. J Natl Cancer Inst. 2022. PMID: 35048954 Free PMC article.
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA1 mutation carriers, 10 years of COCP use from age 20 to 30 years resulted in 66 additional COCP-associated cancer cases by the age of 35 ye …
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA …
Robust and durable serological response following pediatric SARS-CoV-2 infection.
Renk H, Dulovic A, Seidel A, Becker M, Fabricius D, Zernickel M, Junker D, Groß R, Müller J, Hilger A, Bode SFN, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaiser PD, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann GF, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Münch J, Stamminger T, Groß HJ, Wolkewitz M, Engel C, Liu W, Rizzi M, Hahn BH, Henneke P, Franz AR, Debatin KM, Schneiderhan-Marra N, Janda A, Elling R. Renk H, et al. Among authors: engel c. Nat Commun. 2022 Jan 10;13(1):128. doi: 10.1038/s41467-021-27595-9. Nat Commun. 2022. PMID: 35013206 Free PMC article.
Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic i …
Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the …
Association of plasma trimethylamine N-oxide levels with atherosclerotic cardiovascular disease and factors of the metabolic syndrome.
Ringel C, Dittrich J, Gaudl A, Schellong P, Beuchel CF, Baber R, Beutner F, Teren A, Engel C, Wirkner K, Thiele H, Büttner P, Löffler M, Scholz M, Thiery J, Ceglarek U. Ringel C, et al. Among authors: engel c. Atherosclerosis. 2021 Oct;335:62-67. doi: 10.1016/j.atherosclerosis.2021.09.026. Epub 2021 Sep 23. Atherosclerosis. 2021. PMID: 34583200
Associations with ASCVD manifestations, metabolic syndrome, 30-day mortality of patients with AMI and CS, and long-term mortality of subjects with suspected coronary artery disease (CAD) were analyzed. ...The latter association was confirmed in LIFE-Adult. We found no asso …
Associations with ASCVD manifestations, metabolic syndrome, 30-day mortality of patients with AMI and CS, and long-term mortality of …
General practitioners' views and experiences in caring for patients after sepsis: a qualitative interview study.
Gehrke-Beck S, Gensichen J, Turner KM, Heintze C, Schmidt KF; SMOOTH Study Group. Gehrke-Beck S, et al. BMJ Open. 2021 Feb 10;11(2):e040533. doi: 10.1136/bmjopen-2020-040533. BMJ Open. 2021. PMID: 33568366 Free PMC article. Clinical Trial.
BACKGROUND: Patients surviving critical illnesses, such as sepsis, often suffer from long-term complications. After discharge from hospital, most patients are treated in primary care. ...Better communication at the intensive care unit-GP interface and training in managemen …
BACKGROUND: Patients surviving critical illnesses, such as sepsis, often suffer from long-term complications. After discharge from ho …
Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study.
Schrijver LH, Antoniou AC, Olsson H, Mooij TM, Roos-Blom MJ, Azarang L, Adlard J, Ahmed M, Barrowdale D, Davidson R, Donaldson A, Eeles R, Evans DG, Frost D, Henderson A, Izatt L, Ong KR, Bonadona V, Coupier I, Faivre L, Fricker JP, Gesta P, van Engelen K, Jager A, Menko FH, Mourits MJE, Singer CF, Tan YY, Foretova L, Navratilova M, Schmutzler RK, Ellberg C, Gerdes AM, Caldes T, Simard J, Olah E, Jakubowska A, Rantala J, Osorio A, Hopper JL, Phillips KA, Milne RL, Beth Terry M, Noguès C, Engel C, Kast K, Goldgar DE, van Leeuwen FE, Easton DF, Andrieu N, Rookus MA; Epidemiological Study of Familial Breast Cancer, Gene Etude Prospective Sein Ovaire Sein, Hereditary Breast and Ovarian Cancer Research Group Netherlands, and International BRCA1/2 Carrier Cohort Study. Schrijver LH, et al. Among authors: engel c. Am J Obstet Gynecol. 2021 Jul;225(1):51.e1-51.e17. doi: 10.1016/j.ajog.2021.01.014. Epub 2021 Jan 22. Am J Obstet Gynecol. 2021. PMID: 33493488 Free PMC article.
Age-dependent-weighted Cox regression analyses were stratified by study and birth cohort and included breast cancer diagnosis as a covariate. ...CONCLUSION: For BRCA1 mutation carriers, longer duration of oral contraceptive use is associated with a greater reduction in ova …
Age-dependent-weighted Cox regression analyses were stratified by study and birth cohort and included breast cancer diagnosis as a co …
42 results