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Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy.
Paolone G, Falcicchia C, Lovisari F, Kokaia M, Bell WJ, Fradet T, Barbieri M, Wahlberg LU, Emerich DF, Simonato M. Paolone G, et al. Among authors: emerich df. J Neurosci. 2019 Mar 13;39(11):2144-2156. doi: 10.1523/JNEUROSCI.0435-18.2018. Epub 2019 Jan 21. J Neurosci. 2019. PMID: 30665947 Free PMC article.
In vivo studies demonstrated that bilateral intrahippocampal implants continued to secrete GDNF that produced high hippocampal GDNF tissue levels in a long-term manner. Identical implants robustly reduced seizure frequency in the pilocarpine model. ...
In vivo studies demonstrated that bilateral intrahippocampal implants continued to secrete GDNF that produced high hippocampal GDNF tissue l …
Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy.
Falcicchia C, Paolone G, Emerich DF, Lovisari F, Bell WJ, Fradet T, Wahlberg LU, Simonato M. Falcicchia C, et al. Among authors: emerich df. Mol Ther Methods Clin Dev. 2018 Mar 9;9:211-224. doi: 10.1016/j.omtm.2018.03.001. eCollection 2018 Jun 15. Mol Ther Methods Clin Dev. 2018. PMID: 29766029 Free PMC article.
These benefits were associated with improved cognitive performance, as epileptic rats treated with BDNF performed significantly better on a novel object recognition test. Importantly, long-term BDNF delivery did not alter normal behaviors such as general activity or sleep/ …
These benefits were associated with improved cognitive performance, as epileptic rats treated with BDNF performed significantly better on a …
Encapsulated cell therapy for neurodegenerative diseases: from promise to product.
Emerich DF, Orive G, Thanos C, Tornoe J, Wahlberg LU. Emerich DF, et al. Adv Drug Deliv Rev. 2014 Apr;67-68:131-41. doi: 10.1016/j.addr.2013.07.008. Epub 2013 Jul 21. Adv Drug Deliv Rev. 2014. PMID: 23880505 Review.
Delivering therapeutic molecules, including trophic factor proteins, across the blood brain barrier to the brain parenchyma to treat chronic neurodegenerative diseases remains one of the great challenges in biology. To be effective, delivery needs to occur in a long-term a …
Delivering therapeutic molecules, including trophic factor proteins, across the blood brain barrier to the brain parenchyma to treat chronic …
The efficacy of intracranial PLG-based vaccines is dependent on direct implantation into brain tissue.
Ali OA, Doherty E, Bell WJ, Fradet T, Hudak J, Laliberte MT, Mooney DJ, Emerich DF. Ali OA, et al. Among authors: emerich df. J Control Release. 2011 Sep 25;154(3):249-57. doi: 10.1016/j.jconrel.2011.06.021. Epub 2011 Jun 16. J Control Release. 2011. PMID: 21704093
Rats bearing seven-day old, intracranial glioma tumors were treated with PLG vaccines implanted into the tumor bed, resulting in retention of contralateral forelimb function (day 17) that is compromised by tumor formation in control animals, and 90% long-term survival (&gt …
Rats bearing seven-day old, intracranial glioma tumors were treated with PLG vaccines implanted into the tumor bed, resulting in retention o …
Biomaterial-based vaccine induces regression of established intracranial glioma in rats.
Ali OA, Doherty E, Bell WJ, Fradet T, Hudak J, Laliberte MT, Mooney DJ, Emerich DF. Ali OA, et al. Among authors: emerich df. Pharm Res. 2011 May;28(5):1074-80. doi: 10.1007/s11095-010-0361-x. Epub 2011 Jan 12. Pharm Res. 2011. PMID: 21225320
Histological analysis quantitatively confirmed a robust and rapid reduction in tumor size. Long-term immunity was confirmed when 67% of survivors also survived a second glioma challenge. ...
Histological analysis quantitatively confirmed a robust and rapid reduction in tumor size. Long-term immunity was confirmed when 67% …
Use of Sertoli cell transplants to provide local immunoprotection for tissue grafts.
Halberstadt C, Emerich DF, Gores P. Halberstadt C, et al. Among authors: emerich df. Expert Opin Biol Ther. 2004 Jun;4(6):813-25. doi: 10.1517/14712598.4.6.813. Expert Opin Biol Ther. 2004. PMID: 15174964 Review.
Unfortunately, widespread clinical use of cell transplantation is limited by tissue availability and the need for long-term immunosuppresion. Testicular Sertoli cells can confer local immunoprotection for co-transplanted cells and may provide a means of overcoming the obst …
Unfortunately, widespread clinical use of cell transplantation is limited by tissue availability and the need for long-term immunosup …
Harnessing the immunomodulatory properties of Sertoli cells to enable xenotransplantation in type I diabetes.
Dufour JM, Rajotte RV, Korbutt GS, Emerich DF. Dufour JM, et al. Among authors: emerich df. Immunol Invest. 2003 Nov;32(4):275-97. doi: 10.1081/imm-120025106. Immunol Invest. 2003. PMID: 14603995 Review.
Islet transplantation has emerged as a viable long-term means of treating type I diabetes. This is largely due to the success of the "Edmonton protocol" which has produced insulin independence in 85% of patients 1 year after transplantation of allogeneic islets together wi …
Islet transplantation has emerged as a viable long-term means of treating type I diabetes. This is largely due to the success of the …
Complications of a trophic xenotransplant approach in parkinsonian monkeys.
Blanchet PJ, Konitsiotis S, Mochizuki H, Pluta R, Emerich DF, Chase TN, Mouradian MM. Blanchet PJ, et al. Among authors: emerich df. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):607-12. doi: 10.1016/s0278-5846(03)00048-4. Prog Neuropsychopharmacol Biol Psychiatry. 2003. PMID: 12787846
Intracerebral implantation of engineered cells encapsulated in a semipermeable polymer membrane constitutes one way to deliver bioactive substances unable to cross the blood-brain barrier while avoiding the need for long-term immunosuppression. Glial cell line-derived neur …
Intracerebral implantation of engineered cells encapsulated in a semipermeable polymer membrane constitutes one way to deliver bioactive sub …
Injection of chemotherapeutic microspheres and glioma. IV: Eradicating tumors in rats.
Emerich DF, Winn SR, Bartus RT. Emerich DF, et al. Cell Transplant. 2002;11(1):47-54. Cell Transplant. 2002. PMID: 12095219
At the higher dose (800 microg), one third of the animals receiving two separate treatments were long-term survivors (> 150 days) and showed complete eradication of the tumor on histological examination. ...
At the higher dose (800 microg), one third of the animals receiving two separate treatments were long-term survivors (> 150 days) …
18 results