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Quantitative Sensory Changes Following Gasserian Ganglion Radiofrequency Thermocoagulation in Patients with Medical Refractory Trigeminal Neuralgia: A Prospective Consecutive Case Series.
Huckhagel T, Bohlmann L, Westphal M, Regelsberger J, Eichler IC, Hamel W. Huckhagel T, et al. Among authors: eichler ic. J Neurol Surg A Cent Eur Neurosurg. 2020 Sep;81(5):423-429. doi: 10.1055/s-0039-1698386. Epub 2020 Jan 21. J Neurol Surg A Cent Eur Neurosurg. 2020. PMID: 31962356
Apart from clinical reports on a variable manifestation of facial hypoesthesia, the long-term impact of trigeminal ganglion radiofrequency thermocoagulation (RFT) on sensory characteristics has not yet been determined using quantitative methods. ...CONCLUSION: Our data sug …
Apart from clinical reports on a variable manifestation of facial hypoesthesia, the long-term impact of trigeminal ganglion radiofreq …
Altered Signaling in the Descending Pain-modulatory System after Short-Term Infusion of the mu-Opioid Agonist Remifentanil.
Sprenger C, Eichler IC, Eichler L, Zöllner C, Büchel C. Sprenger C, et al. Among authors: eichler ic. J Neurosci. 2018 Mar 7;38(10):2454-2470. doi: 10.1523/JNEUROSCI.2496-17.2018. Epub 2018 Feb 12. J Neurosci. 2018. PMID: 29440535 Free PMC article.
mu-Opioid receptor agonists are widely used within the contemporary treatment of pain, but abrupt opioid suspension, even after short-term infusion, can paradoxically increase the sensitivity to noxious stimuli, a phenomenon that has been, for example, reported after appli …
mu-Opioid receptor agonists are widely used within the contemporary treatment of pain, but abrupt opioid suspension, even after short-ter
Close collaboration between academia, industry and drug regulators is required in the development of allergen products for specific immunotherapy in children.
Eichler I, Soriano ES. Eichler I, et al. Allergy. 2011 Aug;66(8):999-1004. doi: 10.1111/j.1398-9995.2011.02582.x. Epub 2011 Mar 23. Allergy. 2011. PMID: 21426358
However, although allergen products for SIT have been on the market on a named-patient basis for many years, long-term efficacy, the optimal duration of the treatment and the optimal dosage have not been sufficiently elaborated until now. ...
However, although allergen products for SIT have been on the market on a named-patient basis for many years, long-term efficacy, the …
Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection.
Grgic I, Wulff H, Eichler I, Flothmann C, Köhler R, Hoyer J. Grgic I, et al. Among authors: eichler i. Transplant Proc. 2009 Jul-Aug;41(6):2601-6. doi: 10.1016/j.transproceed.2009.06.025. Transplant Proc. 2009. PMID: 19715983 Free PMC article.
Currently, there is an unmet clinical need for novel immunosuppressive agents for long-term prevention of kidney transplant rejection as alternatives to the nephrotoxic calcineurin inhibitor cyclosporine (CsA). ...
Currently, there is an unmet clinical need for novel immunosuppressive agents for long-term prevention of kidney transplant rejection …
Shear stress-induced up-regulation of the intermediate-conductance Ca(2+)-activated K(+) channel in human endothelium.
Brakemeier S, Kersten A, Eichler I, Grgic I, Zakrzewicz A, Hopp H, Köhler R, Hoyer J. Brakemeier S, et al. Among authors: eichler i. Cardiovasc Res. 2003 Dec 1;60(3):488-96. doi: 10.1016/j.cardiores.2003.09.010. Cardiovasc Res. 2003. PMID: 14659794
Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 prevented the LSS-induced up-regulation of IKCa1 expression levels and IK(Ca) whole-cell currents indicating that augmentation of IKCa1 expressio …
Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 preve …
Negative expiratory pressure: a new tool for evaluating lung function in children?
Tauber E, Fazekas T, Eichler I, Eichstill C, Gartner C, Koller DY, Frischer T. Tauber E, et al. Among authors: eichler i. Pediatr Pulmonol. 2003 Mar;35(3):162-8. doi: 10.1002/ppul.10233. Pediatr Pulmonol. 2003. PMID: 12567383
In healthy children, the intraclass coefficient of correlation was 77%, and intraindividual short- and long-term variability was 5.8% and 10.8%, respectively. In asthmatics, TEF(50) was lower compared with controls, and increased after inhalation of salbutamol. ...
In healthy children, the intraclass coefficient of correlation was 77%, and intraindividual short- and long-term variability was 5.8% …
Long-term oral beta-carotene supplementation in patients with cystic fibrosis - effects on antioxidative status and pulmonary function.
Rust P, Eichler I, Renner S, Elmadfa I. Rust P, et al. Among authors: eichler i. Ann Nutr Metab. 2000;44(1):30-7. doi: 10.1159/000012818. Ann Nutr Metab. 2000. PMID: 10838464 Clinical Trial.
To investigate the efficacy of long-term oral beta-carotene supplementation for optimizing the antioxidant status and pulmonary function in patients with cystic fibrosis (CF), 24 patients (aged 12. 8 +/- 6.3 years) were randomized to a CF supplementation or to a CF placebo …
To investigate the efficacy of long-term oral beta-carotene supplementation for optimizing the antioxidant status and pulmonary funct …
Late pulmonary sequelae of bronchopulmonary dysplasia.
Northway WH Jr, Moss RB, Carlisle KB, Parker BR, Popp RL, Pitlick PT, Eichler I, Lamm RL, Brown BW Jr. Northway WH Jr, et al. Among authors: eichler i. N Engl J Med. 1990 Dec 27;323(26):1793-9. doi: 10.1056/NEJM199012273232603. N Engl J Med. 1990. PMID: 2247118 Free article.
It has become the most common form of chronic lung disease in infants in the United States. The long-term outcome for infants with bronchopulmonary dysplasia has not been determined. ...We compared the results with those in two control groups: 26 age-matched adolescents an …
It has become the most common form of chronic lung disease in infants in the United States. The long-term outcome for infants with br …
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