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How satisfied are cervical dystonia patients after 3 years of botulinum toxin type A treatment? Results from a prospective, long-term observational study.
Colosimo C, Charles D, Misra VP, Maisonobe P, Om S; INTEREST IN CD2 study group. Colosimo C, et al. J Neurol. 2019 Dec;266(12):3038-3046. doi: 10.1007/s00415-019-09527-2. Epub 2019 Sep 9. J Neurol. 2019. PMID: 31501975 Free PMC article.
BACKGROUND: Patients with cervical dystonia (CD) typically require regular injections of botulinum toxin to maintain symptomatic control. We aimed to document long-term patient satisfaction with CD symptom control in a large cohort of patients treated in routine practice. …
BACKGROUND: Patients with cervical dystonia (CD) typically require regular injections of botulinum toxin to maintain symptomatic control. We …
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M, Iskratsch T. Pandey P, et al. Among authors: ehler e. Dev Cell. 2018 Feb 5;44(3):326-336.e3. doi: 10.1016/j.devcel.2017.12.024. Epub 2018 Jan 26. Dev Cell. 2018. PMID: 29396114 Free PMC article.
Finally, PKC and non-muscle myosin are upregulated at the costameres in heart disease, indicating aberrant mechanosensing as a contributing factor to long-term remodeling and heart failure....
Finally, PKC and non-muscle myosin are upregulated at the costameres in heart disease, indicating aberrant mechanosensing as a contributing …
INTEREST IN CD2, a global patient-centred study of long-term cervical dystonia treatment with botulinum toxin.
Misra VP, Colosimo C, Charles D, Chung TM, Maisonobe P, Om S; INTEREST IN CD2 study group. Misra VP, et al. J Neurol. 2018 Feb;265(2):402-409. doi: 10.1007/s00415-017-8698-2. Epub 2017 Dec 21. J Neurol. 2018. PMID: 29270685 Free PMC article.
METHODS: INTEREST IN CD2 (NCT01753349) is a prospective, international, 3-year, longitudinal, observational study following the course of adult idiopathic cervical dystonia (CD) treated with botulinum neurotoxin type A (BoNT-A). The primary objective is to document long-term …
METHODS: INTEREST IN CD2 (NCT01753349) is a prospective, international, 3-year, longitudinal, observational study following the course of ad …
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, Linke W, van der Velden J. Dos Remedios CG, et al. Among authors: ehler e. Biophys Rev. 2017 Aug;9(4):431-441. doi: 10.1007/s12551-017-0305-3. Epub 2017 Aug 14. Biophys Rev. 2017. PMID: 28808947 Free PMC article. Review.
The tissues most commonly requested are from donor left ventricles, but right ventricles, atria, interventricular system, and coronary arteries vessels have also been reported. All tissues are stored for long-term use in liquid N or vapor (170-180 C), and are shipped under …
The tissues most commonly requested are from donor left ventricles, but right ventricles, atria, interventricular system, and coronary arter …
A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain.
Hoggart B, Ratcliffe S, Ehler E, Simpson KH, Hovorka J, Lejčko J, Taylor L, Lauder H, Serpell M. Hoggart B, et al. Among authors: ehler e. J Neurol. 2015 Jan;262(1):27-40. doi: 10.1007/s00415-014-7502-9. Epub 2014 Sep 30. J Neurol. 2015. PMID: 25270679 Clinical Trial.
Peripheral neuropathic pain (PNP) poses a significant clinical challenge. The long-term efficacy of delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray was investigated in this 38-week open-label extension study. ...THC/CBD spray was well tolerated for th …
Peripheral neuropathic pain (PNP) poses a significant clinical challenge. The long-term efficacy of delta-9-tetrahydrocannabinol (THC …
Impact of fingolimod therapy on magnetic resonance imaging outcomes in patients with multiple sclerosis.
Radue EW, O'Connor P, Polman CH, Hohlfeld R, Calabresi P, Selmaj K, Mueller-Lenke N, Agoropoulou C, Holdbrook F, de Vera A, Zhang-Auberson L, Francis G, Burtin P, Kappos L; FTY720 Research Evaluating Effects of Daily Oral Therapy in Multiple Sclerosis (FREEDOMS) Study Group. Radue EW, et al. Arch Neurol. 2012 Oct;69(10):1259-69. doi: 10.1001/archneurol.2012.1051. Arch Neurol. 2012. PMID: 22751847 Clinical Trial.
CONCLUSION: These results, coupled with the significant reductions in relapse rates and disability progression reported previously, support the positive impact on long-term disease evolution. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00289978...
CONCLUSION: These results, coupled with the significant reductions in relapse rates and disability progression reported previously, support …
Stiff-person syndrome following tick-borne meningoencephalitis.
Ehler E, Latta J, Mandysová P, Havlasová J, Mrklovský M. Ehler E, et al. Acta Medica (Hradec Kralove). 2011;54(4):170-4. doi: 10.14712/18059694.2016.44. Acta Medica (Hradec Kralove). 2011. PMID: 22283113
After therapeutic plasma exchange (TPE) a rapid, temporary improvement of the clinical and neurophysiological findings was noted. Only after being placed on long-term immunosuppression did the patient achieve stable recovery. This case supports the importance of EMG findin …
After therapeutic plasma exchange (TPE) a rapid, temporary improvement of the clinical and neurophysiological findings was noted. Only after …
Exposure to iodomethane and dichloromethane associated with a confusional state.
Ehler E, Latta J, Eichlerová A, Mrklovský M, Urban P. Ehler E, et al. Neurotoxicology. 2011 Jun;32(3):307-11. doi: 10.1016/j.neuro.2011.02.003. Epub 2011 Feb 15. Neurotoxicology. 2011. PMID: 21329723
Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure to both substances had been experiencing headaches, dizziness and fatigue for about 5 years. ...
Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure …
17 results