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Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
The benefits of mechanical insufflator-exsufflator compared to autogenic drainage in adults with cystic fibrosis.
Helper N, Kodesh E, Sokol G, Hakimi R, Vilozni D, Efrati O. Helper N, et al. Among authors: efrati o. Pediatr Pulmonol. 2020 Nov;55(11):3046-3052. doi: 10.1002/ppul.25020. Epub 2020 Aug 24. Pediatr Pulmonol. 2020. PMID: 32776649 Clinical Trial.
CONCLUSIONS: Treatment with the MI-E was more effective for clearing sputum in CF subjects, initial evidence suggests that the MI-E may be successfully incorporated into treatment protocols. Further studies are needed to assess the long-term benefits of MI-E in patients wi …
CONCLUSIONS: Treatment with the MI-E was more effective for clearing sputum in CF subjects, initial evidence suggests that the MI-E may be s …
Nutritional Status in Childhood as a Prognostic Factor in Patients with Cystic Fibrosis.
Ashkenazi M, Nathan N, Sarouk I, Aluma BEB, Dagan A, Bezalel Y, Keler S, Vilozni D, Efrati O. Ashkenazi M, et al. Among authors: efrati o. Lung. 2019 Jun;197(3):371-376. doi: 10.1007/s00408-019-00218-3. Epub 2019 Mar 18. Lung. 2019. PMID: 30887107
To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population. ...
To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung f …
Ambulatory blood pressure profiles in familial dysautonomia.
Goldberg L, Bar-Aluma BE, Krauthammer A, Efrati O, Sharabi Y. Goldberg L, et al. Among authors: efrati o. Clin Auton Res. 2018 Aug;28(4):385-390. doi: 10.1007/s10286-018-0507-1. Epub 2018 Feb 12. Clin Auton Res. 2018. PMID: 29435868
The diurnal blood pressure profile, including the average, variability, and day-night difference, may have implications for long-term end organ damage. The purpose of this study was to describe the circadian pattern of blood pressure in the FD population and relationships …
The diurnal blood pressure profile, including the average, variability, and day-night difference, may have implications for long-term …
A Controlled Trial of Inhaled Bronchodilators in Familial Dysautonomia.
Bar-Aluma BE, Efrati O, Kaufmann H, Palma JA, Norcliffe-Kaufmann L. Bar-Aluma BE, et al. Among authors: efrati o. Lung. 2018 Feb;196(1):93-101. doi: 10.1007/s00408-017-0073-7. Epub 2017 Dec 12. Lung. 2018. PMID: 29234869 Clinical Trial.
CONCLUSION: Airway obstruction is pharmacologically reversible in a number of patients with FD. In the short term, both albuterol and ipratropium were well tolerated and not associated with major cardiovascular adverse events....
CONCLUSION: Airway obstruction is pharmacologically reversible in a number of patients with FD. In the short term, both albuterol and …
Impact of an extended challenge on the effectiveness of β-lactam hypersensitivity investigation.
Ratzon R, Reshef A, Efrati O, Deutch M, Forschmidt R, Cukierman-Yaffe T, Kenett R, Kidon MI. Ratzon R, et al. Among authors: efrati o. Ann Allergy Asthma Immunol. 2016 Apr;116(4):329-33. doi: 10.1016/j.anai.2016.01.018. Epub 2016 Feb 26. Ann Allergy Asthma Immunol. 2016. PMID: 26922211
Unless an immediate reaction was clearly documented, patients were offered a 7-day, extended DPT. Long-term effectiveness, calculated as the subsequent use of the tested antibiotic, and satisfaction levels were assessed with a telephone questionnaire. ...
Unless an immediate reaction was clearly documented, patients were offered a 7-day, extended DPT. Long-term effectiveness, calculated …
The Short-Term Effect of Breathing Tasks Via an Incentive Spirometer on Lung Function Compared With Autogenic Drainage in Subjects With Cystic Fibrosis.
Sokol G, Vilozni D, Hakimi R, Lavie M, Sarouk I, Bat-El Bar, Dagan A, Ofek M, Efrati O. Sokol G, et al. Among authors: efrati o. Respir Care. 2015 Dec;60(12):1819-25. doi: 10.4187/respcare.04008. Epub 2015 Sep 15. Respir Care. 2015. PMID: 26374905 Free article.
Expiratory resistive breathing via a handheld incentive spirometer has the potential to control the expiratory flow via chosen resistances (1-8 mm) and thereby mobilize secretions and improve lung function. Our objective was to explore the short-term effect of using a resi …
Expiratory resistive breathing via a handheld incentive spirometer has the potential to control the expiratory flow via chosen resistances ( …
Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis.
Lavie M, Manovitz T, Vilozni D, Levy-Mendelovich S, Sarouk I, Weintraubv I, Shoseyov D, Cohen-Cymberknoh M, Rivlin J, Efrati O. Lavie M, et al. Among authors: efrati o. World J Gastroenterol. 2015 Jan 7;21(1):318-25. doi: 10.3748/wjg.v21.i1.318. World J Gastroenterol. 2015. PMID: 25574107 Free PMC article.
AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome (DIOS) in Israeli cystic fibrosis (CF) patients. ...
AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome (DIOS) in Israeli cystic fibrosis (CF) patients …
Outcome of patients with cystic fibrosis admitted to the intensive care unit: is invasive mechanical ventilation a risk factor for death in patients waiting lung transplantation?
Efrati O, Bylin I, Segal E, Vilozni D, Modan-Moses D, Vardi A, Szeinberg A, Paret G. Efrati O, et al. Heart Lung. 2010 Mar-Apr;39(2):153-9. doi: 10.1016/j.hrtlng.2009.06.014. Epub 2009 Aug 25. Heart Lung. 2010. PMID: 20207276
OBJECTIVE: The admission of patients with cystic fibrosis (CF) to the intensive care unit (ICU) is controversial. Our aim was to study the long-term outcome of patients with CF who were admitted to the ICU and the effect of ventilation modality. ...
OBJECTIVE: The admission of patients with cystic fibrosis (CF) to the intensive care unit (ICU) is controversial. Our aim was to study the l …
Spirometry follow-up in young children with hemato-oncologic diseases.
Efrati O, Toren A, Duskin H, Goldstein G, Jacobson JM, Churi C, Vilozni D. Efrati O, et al. Med Sci Monit. 2010 Mar;16(3):MT28-33. Med Sci Monit. 2010. PMID: 20190695
Values were compared to those of healthy children of corresponding age. RESULTS: Most children (n=38) showed only minor long term airflow impairment (z-scores of FEV1 at last measurement was -0.00 to -0.45 SD). ...
Values were compared to those of healthy children of corresponding age. RESULTS: Most children (n=38) showed only minor long term air …
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