Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice.
da Cunha MF, Pranke I, Sassi A, Schreiweis C, Moriceau S, Vidovic D, Hatton A, Carlon MS, Creste G, Berhal F, Prestat G, Freund R, Odolczyk N, Jais JP, Gravier-Pelletier C, Zielenkiewicz P, Jullien V, Hinzpeter A, Oury F, Edelman A, Sermet-Gaudelus I.
da Cunha MF, et al. Among authors: edelman a.
Sci Rep. 2022 Apr 12;12(1):6132. doi: 10.1038/s41598-022-09678-9.
Sci Rep. 2022.
PMID: 35413967
Free PMC article.
Using nasal potential difference measurement, we showed that in vivo administration of c407 by topical, short-term intraperitoneal and long-term subcutaneous route significantly increased the CFTR dependent chloride (Cl(-)) conductance in F508del Cftr(tm1Eur) mice. …
Using nasal potential difference measurement, we showed that in vivo administration of c407 by topical, short-term intraperitoneal an …