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Baseline Stroke Risk and Efficacy of Dual-Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial.
Daghlas I, Johnston SC, Easton JD, Kim AS. Daghlas I, et al. Among authors: easton jd. Stroke. 2024 Feb;55(2):385-391. doi: 10.1161/STROKEAHA.123.044927. Epub 2024 Jan 4. Stroke. 2024. PMID: 38174567
RESULTS: A total of 4841 trial participants were included in this analysis, with 2400 participants assigned to treatment with short-term DAPT and 2430 participants to treatment with aspirin and placebo. ...
RESULTS: A total of 4841 trial participants were included in this analysis, with 2400 participants assigned to treatment with short-term …
Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation.
Gammie JS, Chu MWA, Falk V, Overbey JR, Moskowitz AJ, Gillinov M, Mack MJ, Voisine P, Krane M, Yerokun B, Bowdish ME, Conradi L, Bolling SF, Miller MA, Taddei-Peters WC, Jeffries NO, Parides MK, Weisel R, Jessup M, Rose EA, Mullen JC, Raymond S, Moquete EG, O'Sullivan K, Marks ME, Iribarne A, Beyersdorf F, Borger MA, Geirsson A, Bagiella E, Hung J, Gelijns AC, O'Gara PT, Ailawadi G; CTSN Investigators. Gammie JS, et al. N Engl J Med. 2022 Jan 27;386(4):327-339. doi: 10.1056/NEJMoa2115961. Epub 2021 Nov 13. N Engl J Med. 2022. PMID: 34767705 Free PMC article. Clinical Trial.
Whether reduced progression of tricuspid regurgitation results in long-term clinical benefit can be determined only with longer follow-up. ...
Whether reduced progression of tricuspid regurgitation results in long-term clinical benefit can be determined only with longer follo …
Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source: An Analysis of the RE-SPECT ESUS Trial.
Bahit MC, Sacco RL, Easton JD, Meyerhoff J, Cronin L, Kleine E, Grauer C, Brueckmann M, Diener HC, Lopes RD, Brainin M, Lyrer P, Wachter R, Segura T, Granger CB; RE-SPECT ESUS Steering Committee and Investigators. Bahit MC, et al. Among authors: easton jd. Circulation. 2021 Nov 30;144(22):1738-1746. doi: 10.1161/CIRCULATIONAHA.121.055176. Epub 2021 Oct 15. Circulation. 2021. PMID: 34649459 Free article. Clinical Trial.
Understanding who is at higher risk of developing AF will assist in identifying patients who may benefit from more intense, long-term cardiac monitoring. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02239120....
Understanding who is at higher risk of developing AF will assist in identifying patients who may benefit from more intense, long-term …
Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial.
de Havenon A, Johnston SC, Easton JD, Kim AS, Sheth KN, Lansberg M, Tirschwell D, Mistry E, Yaghi S. de Havenon A, et al. Among authors: easton jd. JAMA Netw Open. 2021 Jun 1;4(6):e2112551. doi: 10.1001/jamanetworkopen.2021.12551. JAMA Netw Open. 2021. PMID: 34086033 Free PMC article.
EXPOSURES: Baseline SBP less than 140 mm Hg vs greater than or equal to 140 mm Hg and the interaction term of SBP (<140 mm Hg vs 140 mm Hg) treatment group (aspirin vs DAPT). ...When evaluating the outcome of ischemic stroke within 7 days of randomization, the interacti …
EXPOSURES: Baseline SBP less than 140 mm Hg vs greater than or equal to 140 mm Hg and the interaction term of SBP (<140 mm Hg vs 1 …
Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial.
Toyoda K, Uchiyama S, Yamaguchi T, Easton JD, Kimura K, Hoshino H, Sakai N, Okada Y, Tanaka K, Origasa H, Naritomi H, Houkin K, Yamaguchi K, Isobe M, Minematsu K; CSPS.com Trial Investigators. Toyoda K, et al. Among authors: easton jd. Lancet Neurol. 2019 Jun;18(6):539-548. doi: 10.1016/S1474-4422(19)30148-6. Lancet Neurol. 2019. PMID: 31122494 Clinical Trial.
BACKGROUND: Although dual antiplatelet therapy with aspirin and clopidogrel reduces early recurrence of ischaemic stroke, with long-term use this type of therapy is no longer effective and the risk of bleeding increases. Given that cilostazol prevents stroke recurrence wit …
BACKGROUND: Although dual antiplatelet therapy with aspirin and clopidogrel reduces early recurrence of ischaemic stroke, with long-term …
Risk for Major Hemorrhages in Patients Receiving Clopidogrel and Aspirin Compared With Aspirin Alone After Transient Ischemic Attack or Minor Ischemic Stroke: A Secondary Analysis of the POINT Randomized Clinical Trial.
Tillman H, Johnston SC, Farrant M, Barsan W, Elm JJ, Kim AS, Lindblad AS, Palesch YY, Easton JD. Tillman H, et al. Among authors: easton jd. JAMA Neurol. 2019 Jul 1;76(7):774-782. doi: 10.1001/jamaneurol.2019.0932. JAMA Neurol. 2019. PMID: 31034032 Free PMC article. Clinical Trial.
IMPORTANCE: Results show the short-term risk of hemorrhage in treating patients with acute transient ischemic attack (TIA) or minor acute ischemic stroke (AIS) with clopidogrel plus aspirin or aspirin alone. ...
IMPORTANCE: Results show the short-term risk of hemorrhage in treating patients with acute transient ischemic attack (TIA) or minor a …
New opportunities to optimize antithrombotic therapy for secondary stroke prevention.
Kim AS, Easton JD. Kim AS, et al. Among authors: easton jd. Int J Stroke. 2019 Apr;14(3):220-222. doi: 10.1177/1747493019828548. Epub 2019 Feb 6. Int J Stroke. 2019. PMID: 30722755
For antiplatelet therapy, aspirin monotherapy is effective but dual antiplatelet therapy with the combination of aspirin and clopidogrel increases hemorrhage risks over the long term that outweigh potential benefits. In the short term though, both the Clopidogrel in …
For antiplatelet therapy, aspirin monotherapy is effective but dual antiplatelet therapy with the combination of aspirin and clopidogrel inc …
Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE.
Goto S, Merrill P, Wallentin L, Wojdyla DM, Hanna M, Avezum A, Easton JD, Harjola VP, Huber K, Lewis BS, Parkhomenko A, Zhu J, Granger CB, Lopes RD, Alexander JH. Goto S, et al. Among authors: easton jd. Eur Heart J Cardiovasc Pharmacother. 2018 Apr 1;4(2):75-81. doi: 10.1093/ehjcvp/pvy002. Eur Heart J Cardiovasc Pharmacother. 2018. PMID: 29385429 Clinical Trial.

The adjusted hazards of major bleeding were also high short-term (HR 10.37, 95% CI 3.87-27.78; P < 0.001) but not long-term (HR 1.7, 95% CI: 0.77-3.88; P = 0.18). CONCLUSIONS: Thrombo-embolic events were rare but associated with high short- and long-term m

…

The adjusted hazards of major bleeding were also high short-term (HR 10.37, 95% CI 3.87-27.78; P < 0.001) but not long-term

…
Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy.
Lopes RD, Guimarães PO, Kolls BJ, Wojdyla DM, Bushnell CD, Hanna M, Easton JD, Thomas L, Wallentin L, Al-Khatib SM, Held C, Gabriel Melo de Barros E Silva P, Alexander JH, Granger CB, Diener HC. Lopes RD, et al. Among authors: easton jd. Blood. 2017 Jun 1;129(22):2980-2987. doi: 10.1182/blood-2016-08-731638. Epub 2017 Mar 29. Blood. 2017. PMID: 28356246 Free article. Clinical Trial.
ICH occurred at a rate of 0.80% per year with warfarin regardless of INR control and at a rate of 0.33% per year with apixaban and was associated with high short-term morbidity and mortality. This highlights the clinical relevance of reducing ICH by using apixaban rather t …
ICH occurred at a rate of 0.80% per year with warfarin regardless of INR control and at a rate of 0.33% per year with apixaban and was assoc …
The niche of an invasive marine microbe in a subtropical freshwater impoundment.
Hambright KD, Beyer JE, Easton JD, Zamor RM, Easton AC, Hallidayschult TC. Hambright KD, et al. Among authors: easton jd. ISME J. 2015 Jan;9(1):256-64. doi: 10.1038/ismej.2014.103. Epub 2014 Jun 20. ISME J. 2015. PMID: 24950108 Free PMC article.
Advances in molecular techniques have provided new evidence that biogeographic patterns exist in microbes and that dispersal limitation may actually have an important role, yet more recent study using extremely deep sequencing predicts that indeed everything is everywhere. Using …
Advances in molecular techniques have provided new evidence that biogeographic patterns exist in microbes and that dispersal limitation may …
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