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Vascular hyperpermeability, angiogenesis, and stroma generation.
Nagy JA, Dvorak AM, Dvorak HF. Nagy JA, et al. Among authors: dvorak hf. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a006544. doi: 10.1101/cshperspect.a006544. Cold Spring Harb Perspect Med. 2012. PMID: 22355795 Free PMC article. Review.
This article places tumor vascular hyperpermeability in a broader context, relating it to (1) the low-level "basal" permeability of the normal vasculature; (2) the "acute," short-term hyperpermeability induced by vascular permeability factor/vascular endothelial growth fac …
This article places tumor vascular hyperpermeability in a broader context, relating it to (1) the low-level "basal" permeability of the norm …
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
Zukauskas A, Merley A, Li D, Ang LH, Sciuto TE, Salman S, Dvorak AM, Dvorak HF, Jaminet SC. Zukauskas A, et al. Among authors: dvorak hf. Angiogenesis. 2011 Sep;14(3):345-54. doi: 10.1007/s10456-011-9218-0. Epub 2011 May 29. Angiogenesis. 2011. PMID: 21626280 Free PMC article.
TM4SF1 is necessary for the formation of unusually long (up to a 50 mum), thin (~100-300 nm wide), F-actin-poor EC cell projections that we term 'nanopodia'. Immunostaining of nanopodia at both the light and electron microsopic levels localized TM4SF1 in a regularly spaced …
TM4SF1 is necessary for the formation of unusually long (up to a 50 mum), thin (~100-300 nm wide), F-actin-poor EC cell projections that we …
VEGF-A angiogenesis induces a stable neovasculature in adult murine brain.
Stiver SI, Tan X, Brown LF, Hedley-Whyte ET, Dvorak HF. Stiver SI, et al. Among authors: dvorak hf. J Neuropathol Exp Neurol. 2004 Aug;63(8):841-55. doi: 10.1093/jnen/63.8.841. J Neuropathol Exp Neurol. 2004. PMID: 15330339
Together, these findings provide a mechanistic understanding of angiogenesis in cerebral disease processes. Furthermore, the long-term stability of daughter vessels in the absence of exogenous VEGF-A164 expression suggests that VEGF-A may enable therapeutic angiogenesis in …
Together, these findings provide a mechanistic understanding of angiogenesis in cerebral disease processes. Furthermore, the long-term …
Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.
Dvorak HF, Van DeWater L, Bitzer AM, Dvorak AM, Anderson D, Harvey VS, Bach R, Davis GL, DeWolf W, Carvalho AC. Dvorak HF, et al. Cancer Res. 1983 Sep;43(9):4434-42. Cancer Res. 1983. PMID: 6347372
Thirteen of 14 tumor cells or tumor cell lines of guinea pig, mouse, and human origin spontaneously shed procoagulant activity in short-term (4 or 14 to 22 hr) tissue culture under conditions of high cell viability. ...
Thirteen of 14 tumor cells or tumor cell lines of guinea pig, mouse, and human origin spontaneously shed procoagulant activity in short-t …
Surface membrane alterations in guinea pig basophils undergoing anaphylactic degranulation. A scanning electron microscopic study.
Dvorak AM, Osage JE, Dvorak HF, Galli SJ. Dvorak AM, et al. Among authors: dvorak hf. Lab Invest. 1981 Jul;45(1):58-66. Lab Invest. 1981. PMID: 7253564
Purified guinea pig blood basophils in short-term tissue culture were studied by scanning and transmission electron microscopy and by 1-micrometer. light microscopic Epon sections after exposure to specific antigen (sheep serum), to guinea pig serum, or to serum-free mediu …
Purified guinea pig blood basophils in short-term tissue culture were studied by scanning and transmission electron microscopy and by …
Metabolic studies of guinea pig basophilic leukocytes in short-term tissue culture. I. Measurement of histaminesynthesizing capacity by using an isotopic-thin layer chromatographic assay.
Galli SJ, Galli AS, Dvorak AM, Dvorak HF. Galli SJ, et al. Among authors: dvorak hf. J Immunol. 1976 Oct;117(4):1085-92. J Immunol. 1976. PMID: 977943
Mature circulating guinea pig basophils, purified to comprise 25% or more of leukocytes, have been successfully maintained in short-term tissue culture for up to 72 hr. These cells were found to retain the ability to synthesize histamine, as assayed by a new isotopic-thin …
Mature circulating guinea pig basophils, purified to comprise 25% or more of leukocytes, have been successfully maintained in short-term …
Cutaneous basophil hypersensitivity. II. A light and electron microscopic description.
Dvorak HF, Dvorak AM, Simpson BA, Richerson HB, Leskowitz S, Karnovsky MJ. Dvorak HF, et al. J Exp Med. 1970 Sep 1;132(3):558-82. doi: 10.1084/jem.132.3.558. J Exp Med. 1970. PMID: 5523969 Free PMC article.
Such reactions have in the past been designated Jones-Mote hypersensitivity, but we prefer the descriptive term cutaneous basophil hypersensitivity (CBH) for the reasons given. ...
Such reactions have in the past been designated Jones-Mote hypersensitivity, but we prefer the descriptive term cutaneous basophil hy …
Cutaneous basophil hypersensitivity. I. A new look at the Jones-Mote reaction, general characteristics.
Richerson HB, Dvorak HF, Leskowitz S. Richerson HB, et al. Among authors: dvorak hf. J Exp Med. 1970 Sep 1;132(3):546-57. doi: 10.1084/jem.132.3.546. J Exp Med. 1970. PMID: 5523968 Free PMC article.
Because the reactions studied here are operationally different from those described by Jones and Mote and because they have a characteristic histology, the term "cutaneous basophil hypersensitivity" is proposed....
Because the reactions studied here are operationally different from those described by Jones and Mote and because they have a characteristic …