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Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome.
Dunn LEM, Lu F, Su C, Lieberman PM, Baines JD. Dunn LEM, et al. J Virol. 2023 Feb 28;97(2):e0189422. doi: 10.1128/jvi.01894-22. Epub 2023 Feb 6. J Virol. 2023. PMID: 36744959 Free PMC article.
The ability of Epstein-Barr virus (EBV) to switch between latent and lytic infection is key to its long-term persistence, yet the molecular mechanisms behind this switch remain unclear. ...IMPORTANCE The ability of EBV to switch between latent and lytic infection is key to …
The ability of Epstein-Barr virus (EBV) to switch between latent and lytic infection is key to its long-term persistence, yet the mol …
Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus-associated oropharyngeal cancer.
Kang JJ, Yu Y, Chen L, Zakeri K, Gelblum DY, McBride SM, Riaz N, Tsai CJ, Kriplani A, Hung TKW, Fetten JV, Dunn LA, Ho AL, Boyle JO, Ganly IS, Singh B, Sherman EJ, Pfister DG, Wong RJ, Lee NY. Kang JJ, et al. Among authors: dunn la. CA Cancer J Clin. 2023 Mar;73(2):164-197. doi: 10.3322/caac.21758. Epub 2022 Oct 28. CA Cancer J Clin. 2023. PMID: 36305841 Free PMC article. Review.
The most common cancer caused by human papillomavirus (HPV) infection in the United States is oropharyngeal cancer (OPC), and its incidence has been rising since the turn of the century. Because of substantial long-term morbidities with chemoradiation and the favorable pro …
The most common cancer caused by human papillomavirus (HPV) infection in the United States is oropharyngeal cancer (OPC), and its incidence …
Resting and Recharging: A Narrative Review of Strategies to Improve Sleep During Residency Training.
Redinger J, Kabil E, Forkin KT, Kleiman AM, Dunn LK. Redinger J, et al. Among authors: dunn lk. J Grad Med Educ. 2022 Aug;14(4):420-430. doi: 10.4300/JGME-D-21-01035.1. J Grad Med Educ. 2022. PMID: 35991104 Free PMC article. Review.
METHODS: A PubMed literature search was conducted through August 30, 2021, using the terms "resident" and "sleep" in the title or abstract and further narrowed using a third search term. Observational studies, randomized controlled trials, systematic reviews, and meta-anal …
METHODS: A PubMed literature search was conducted through August 30, 2021, using the terms "resident" and "sleep" in the title or abstract a …
Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer.
Eita A, Mohamed N, Rybkin A, Kang JJ, Fiasconaro M, Zhigang Z, Zakeri K, Yu Y, Sadaka E, Sherman E, Dunn L, Cracchiolo J, Wong RJ, Cohen M, Lee NY. Eita A, et al. Among authors: dunn l. Laryngoscope. 2023 May;133(5):1138-1145. doi: 10.1002/lary.30279. Epub 2022 Jul 8. Laryngoscope. 2023. PMID: 35801573 Review.
We aim to review the nonoperative management of T4 laryngeal and hypopharyngeal cancer and report the long-term therapeutic and functional outcomes. METHODS: We reviewed the nonoperative management of T4 laryngeal (n = 44) and hypopharyngeal (n = 53) cancer from 1997 to 20 …
We aim to review the nonoperative management of T4 laryngeal and hypopharyngeal cancer and report the long-term therapeutic and funct …
Evaluation of Substantial Reduction in Elective Radiotherapy Dose and Field in Patients With Human Papillomavirus-Associated Oropharyngeal Carcinoma Treated With Definitive Chemoradiotherapy.
Tsai CJ, McBride SM, Riaz N, Kang JJ, Spielsinger DJ, Waldenberg T, Gelblum D, Yu Y, Chen LC, Zakeri K, Wong RJ, Dunn L, Pfister DG, Sherman EJ, Lee NY. Tsai CJ, et al. Among authors: dunn l. JAMA Oncol. 2022 Mar 1;8(3):364-372. doi: 10.1001/jamaoncol.2021.6416. JAMA Oncol. 2022. PMID: 35050342 Free PMC article.
CONCLUSIONS AND RELEVANCE: This cohort study found that the evaluated de-escalation strategy for elective regions showed favorable clinical outcomes and QOL profiles. Long-term follow-up data will help affirm the efficacy of this strategy as a care option for treating HPV- …
CONCLUSIONS AND RELEVANCE: This cohort study found that the evaluated de-escalation strategy for elective regions showed favorable clinical …
The impact on obstetric and perinatal outcomes in term infants following the introduction of a colour-coded, hierarchical cardiotocography classification system: A retrospective non-inferiority study.
Willis M, Dunn L, Okano S, Janssens S, Kumar S. Willis M, et al. Among authors: dunn l. Aust N Z J Obstet Gynaecol. 2022 Jun;62(3):370-375. doi: 10.1111/ajo.13469. Epub 2021 Dec 17. Aust N Z J Obstet Gynaecol. 2022. PMID: 34921390
Non-insured women with a singleton, non-anomalous, cephalic fetus at term, attempting a vaginal birth with continuous intrapartum CTG were included. ...
Non-insured women with a singleton, non-anomalous, cephalic fetus at term, attempting a vaginal birth with continuous intrapar …
Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy.
Zakeri K, Wang H, Kang JJ, Lee A, Romesser P, Mohamed N, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Chen L, Yu Y, Tsai CJ, McBride SM, Riaz N, Lee N. Zakeri K, et al. Among authors: dunn l. Head Neck. 2021 Apr;43(4):1056-1062. doi: 10.1002/hed.26563. Epub 2021 Feb 19. Head Neck. 2021. PMID: 33606323 Free PMC article.
CONCLUSION: In a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and treatment was well tolerated....
CONCLUSION: In a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and tre …
Chyle Leak Following Radical En Bloc Esophagectomy with Two-Field Nodal Dissection: Predisposing Factors, Management, and Outcomes.
Milito P, Chmelo J, Dunn L, Kamarajah SK, Madhavan A, Wahed S, Immanuel A, Griffin SM, Phillips AW. Milito P, et al. Among authors: dunn l. Ann Surg Oncol. 2021 Jul;28(7):3963-3972. doi: 10.1245/s10434-020-09399-1. Epub 2020 Dec 2. Ann Surg Oncol. 2021. PMID: 33263829 Free PMC article.
However, these data indicate chyle leak does not have a long-term impact on patients and does not affect long-term survival....
However, these data indicate chyle leak does not have a long-term impact on patients and does not affect long-term survival... …
Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing.
Rischin D, Migden MR, Lim AM, Schmults CD, Khushalani NI, Hughes BGM, Schadendorf D, Dunn LA, Hernandez-Aya L, Chang ALS, Modi B, Hauschild A, Ulrich C, Eigentler T, Stein B, Pavlick AC, Geiger JL, Gutzmer R, Alam M, Okoye E, Mathias M, Jankovic V, Stankevich E, Booth J, Li S, Lowy I, Fury MG, Guminski A. Rischin D, et al. Among authors: dunn la. J Immunother Cancer. 2020 Jun;8(1):e000775. doi: 10.1136/jitc-2020-000775. J Immunother Cancer. 2020. PMID: 32554615 Free PMC article. Clinical Trial.
Here we report the primary analysis of fixed dose cemiplimab 350 mg intravenously every 3 weeks (Q3W) (Group 3) and provide a longer-term update after the primary analysis of weight-based cemiplimab 3 mg/kg intravenously every 2 weeks (Q2W) (Group 1) among metastatic CSCC …
Here we report the primary analysis of fixed dose cemiplimab 350 mg intravenously every 3 weeks (Q3W) (Group 3) and provide a longer-term …
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