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The Impasse on Overall Survival in Oncology Reimbursement Decision-Making: How Can We Resolve This?
Lux MP, Ciani O, Dunlop WCN, Ferris A, Friedlander M. Lux MP, et al. Among authors: dunlop wcn. Cancer Manag Res. 2021 Nov 10;13:8457-8471. doi: 10.2147/CMAR.S328058. eCollection 2021. Cancer Manag Res. 2021. PMID: 34795526 Free PMC article.
There are strong opinions about approval and reimbursement in the absence of mature OS data, with concerns over delay in patient access set against concerns about uncertainty in long-term benefit. This position paper reflects our individual views as patient advocate, clini …
There are strong opinions about approval and reimbursement in the absence of mature OS data, with concerns over delay in patient access set …
Cost Effectiveness of Durvalumab in Unresectable Stage III NSCLC: 4-Year Survival Update and Model Validation from a UK Healthcare Perspective.
Dunlop W, van Keep M, Elroy P, Perez ID, Ouwens MJNM, Sarbajna T, Zhang Y, Greystoke A. Dunlop W, et al. Pharmacoecon Open. 2022 Mar;6(2):241-252. doi: 10.1007/s41669-021-00301-7. Epub 2021 Sep 16. Pharmacoecon Open. 2022. PMID: 34532842 Free PMC article.
As patients in the study at the time of the initial submission to NICE were only followed for approximately 2 years, the long-term survival benefit that could be achieved with durvalumab was uncertain. ...Here, we demonstrate that the original cost-effectiveness model accu …
As patients in the study at the time of the initial submission to NICE were only followed for approximately 2 years, the long-term su …
Characteristics and outcomes of Aboriginal and Torres Strait Islander patients with dialysis-dependent kidney disease in Australian intensive care units.
Dunlop WA, Secombe PJ, Agostino JW, van Haren FMP. Dunlop WA, et al. Intern Med J. 2022 Mar;52(3):458-467. doi: 10.1111/imj.15077. Intern Med J. 2022. PMID: 33012108
CKD5D increases the risk of hospitalisation, admission to the intensive care unit (ICU) and mortality compared with patients without CKD5D. There is limited literature describing short-term outcomes of patients with CKD5D who are admitted to the ICU, comparing indigenous a …
CKD5D increases the risk of hospitalisation, admission to the intensive care unit (ICU) and mortality compared with patients without CKD5D. …
Medical perspectives regarding goals-of-care consultations in Emergency Departments.
Levinson M, Walker KJ, Hanning J, Dunlop W, Cheong E, Mills A. Levinson M, et al. Among authors: dunlop w. Psychol Health Med. 2019 Oct;24(9):1137-1147. doi: 10.1080/13548506.2019.1595683. Epub 2019 Mar 29. Psychol Health Med. 2019. PMID: 30924364
ED doctors felt they could recognise end-of-life and that ED visits often prompt consideration of end-of-life care planning. They wanted long-term practitioners to initiate discussions prior to patient deterioration. ...
ED doctors felt they could recognise end-of-life and that ED visits often prompt consideration of end-of-life care planning. They wanted lon …
Testing a new form to document 'Goals-of-Care' discussions regarding plans for end-of-life care for patients in an Australian emergency department.
Mills AC, Levinson M, Dunlop WA, Cheong E, Cowan T, Hanning J, O'Callaghan E, Walker KJ. Mills AC, et al. Among authors: dunlop wa. Emerg Med Australas. 2018 Dec;30(6):777-784. doi: 10.1111/1742-6723.12986. Epub 2018 Apr 16. Emerg Med Australas. 2018. PMID: 29663697
The frequency of section use was: Aims-of-Care 91%; Quality-of-Life 75% (the term was polarising); Functional Impairments 35%; and Outcomes of Value 29%. ...
The frequency of section use was: Aims-of-Care 91%; Quality-of-Life 75% (the term was polarising); Functional Impairments 35%; and Ou …
Use of opioid substitution therapies in the treatment of opioid use disorder: results of a UK cost-effectiveness modelling study.
Kenworthy J, Yi Y, Wright A, Brown J, Maria Madrigal A, Dunlop WCN. Kenworthy J, et al. Among authors: dunlop wcn. J Med Econ. 2017 Jul;20(7):740-748. doi: 10.1080/13696998.2017.1325744. Epub 2017 May 25. J Med Econ. 2017. PMID: 28489467 Free article.
OST treatment also impacted other aspects of criminality and healthcare resource use. LIMITATIONS: The model's 1-year timeframe means long-term costs and benefits, and the influence of changes over time are not captured. ...Further work is required to fully quantify the cl …
OST treatment also impacted other aspects of criminality and healthcare resource use. LIMITATIONS: The model's 1-year timeframe means long- …
Cost-effectiveness of modified-release prednisone in the treatment of moderate to severe rheumatoid arthritis with morning stiffness based on directly elicited public preference values.
Dunlop W, Iqbal I, Khan I, Ouwens M, Heron L. Dunlop W, et al. Clinicoecon Outcomes Res. 2013 Oct 30;5:555-64. doi: 10.2147/CEOR.S47867. eCollection 2013. Clinicoecon Outcomes Res. 2013. PMID: 24204166 Free PMC article.
The model only considers drug costs and there was a lack of comparative long-term data for IR-prednisone. Furthermore, utility benefits were not captured in the clinical setting. ...
The model only considers drug costs and there was a lack of comparative long-term data for IR-prednisone. Furthermore, utility benefi …
Expression of the cyclic AMP-dependent transcription factors, CREB, CREM and ATF2, in the human myometrium during pregnancy and labour.
Bailey J, Sparey C, Phillips RJ, Gilmore K, Robson SC, Dunlop W, Europe-Finner GN. Bailey J, et al. Among authors: dunlop w. Mol Hum Reprod. 2000 Jul;6(7):648-60. doi: 10.1093/molehr/6.7.648. Mol Hum Reprod. 2000. PMID: 10871653
In this context, we show that the altered expression of cAMP response-element binding protein (CREB), cAMP response-element modulator protein (CREM) and activating transcription factor 2 (ATF2) are implicated in the maintenance of myometrial quiescence during fetal maturation and …
In this context, we show that the altered expression of cAMP response-element binding protein (CREB), cAMP response-element modulator protei …
Gestational changes in the levels of transforming growth factor-beta1 (TGFbeta1) and TGFbeta receptor types I and II in the human myometrium.
Hatthachote P, Morgan J, Dunlop W, Europe-Finner GN, Gillespie JI. Hatthachote P, et al. Among authors: dunlop w. J Clin Endocrinol Metab. 1998 Aug;83(8):2987-92. doi: 10.1210/jcem.83.8.4992. J Clin Endocrinol Metab. 1998. PMID: 9709980
As term approaches, a number of key proteins [contraction-associated proteins (CAPs)] are expressed within the human myometrium that are essential for the activation of powerful coordinated contractions during labor. ...These observations support the idea that cytokines, i …
As term approaches, a number of key proteins [contraction-associated proteins (CAPs)] are expressed within the human myometrium that …
Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.
Awad SS, Lamb HK, Morgan JM, Dunlop W, Gillespie JI. Awad SS, et al. Among authors: dunlop w. Biochem J. 1997 Mar 15;322 ( Pt 3)(Pt 3):777-83. doi: 10.1042/bj3220777. Biochem J. 1997. PMID: 9148749 Free PMC article.
It can be speculated that the appearance of this additional isoform in the pregnant myometrium may increase the ability of this tissue to contract at term. Control of expression of the RyR2 gene may therefore be another example of an up-regulated signalling system in pregn …
It can be speculated that the appearance of this additional isoform in the pregnant myometrium may increase the ability of this tissue to co …
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