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Functional model of rat thyroid follicles cultured in Matrigel.
Khoruzhenko A, Miot F, Massart C, Van Sande J, Dumont JE, Beauwens R, Boom A. Khoruzhenko A, et al. Among authors: dumont je. Endocr Connect. 2021 May 24;10(5):570-578. doi: 10.1530/EC-21-0169. Endocr Connect. 2021. PMID: 33909590 Free PMC article.
BACKGROUND: Long-term maintenance of functional activity of thyroid cells is an essential requirement for basic in vitro studies on the physiology and pathology of the thyroid. ...
BACKGROUND: Long-term maintenance of functional activity of thyroid cells is an essential requirement for basic in vitro studies on t …
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence".
Tarabichi M, Antoniou A, Saiselet M, Pita JM, Andry G, Dumont JE, Detours V, Maenhaut C. Tarabichi M, et al. Among authors: dumont je. Cancer Metastasis Rev. 2013 Dec;32(3-4):403-21. doi: 10.1007/s10555-013-9431-y. Cancer Metastasis Rev. 2013. PMID: 23615877 Free PMC article. Review.
In the present review, we attempt to bring together these subjects in a general systems biology narrative. It starts from the roles of what we term entropy of signaling and noise in the initial oncogenic events, to the first major transition of tumorigenesis: the independe …
In the present review, we attempt to bring together these subjects in a general systems biology narrative. It starts from the roles of what …
Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis.
Maenhaut C, Dumont JE, Roger PP, van Staveren WC. Maenhaut C, et al. Among authors: dumont je. Carcinogenesis. 2010 Feb;31(2):149-58. doi: 10.1093/carcin/bgp259. Epub 2009 Oct 25. Carcinogenesis. 2010. PMID: 19858069 Review.
To avoid such assumptions, we propose to use the operational term tumor-propagating cells (TPC); indeed, the cells that initiate transplants did not initiate the cancer. ...
To avoid such assumptions, we propose to use the operational term tumor-propagating cells (TPC); indeed, the cells that initiate tran …
Long-term EGF/serum-treated human thyrocytes mimic papillary thyroid carcinomas with regard to gene expression.
Hébrant A, van Staveren WC, Delys L, Solís DW, Bogdanova T, Andry G, Roger P, Dumont JE, Libert F, Maenhaut C. Hébrant A, et al. Among authors: dumont je. Exp Cell Res. 2007 Sep 10;313(15):3276-84. doi: 10.1016/j.yexcr.2007.06.019. Epub 2007 Jul 4. Exp Cell Res. 2007. PMID: 17689531
Gene expression profiles were obtained by microarrays and compared to the expression profiles of PTCs. An evolution from short-term to long-term EGF/serum-treated cells was found, i.e., a program change showing a distinction between gene expression profiles of short …
Gene expression profiles were obtained by microarrays and compared to the expression profiles of PTCs. An evolution from short-term t …
Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis.
van Staveren WC, Solís DW, Delys L, Venet D, Cappello M, Andry G, Dumont JE, Libert F, Detours V, Maenhaut C. van Staveren WC, et al. Among authors: dumont je. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):413-8. doi: 10.1073/pnas.0507354102. Epub 2005 Dec 28. Proc Natl Acad Sci U S A. 2006. PMID: 16381821 Free PMC article.
This result suggests a progressive sequential process leading to a change of cell program. The gene expression profile of the long-term stimulated cultures resembled the autonomous adenomas, but not papillary carcinomas. The molecular phenotype of the adenomas thus confirm …
This result suggests a progressive sequential process leading to a change of cell program. The gene expression profile of the long-term …
Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts.
Blero D, Zhang J, Pesesse X, Payrastre B, Dumont JE, Schurmans S, Erneux C. Blero D, et al. Among authors: dumont je. FEBS J. 2005 May;272(10):2512-22. doi: 10.1111/j.1742-4658.2005.04672.x. FEBS J. 2005. PMID: 15885100 Free article.
Although the absence of SHIP2 had no effect on basal PtdIns(3,4,5)P(3) levels, we show here that this lipid was significantly upregulated in SHIP2 -/- cells but only after short-term (i.e. 5-10 min) incubation with serum. The difference in PtdIns(3,4,5)P(3) levels in heter …
Although the absence of SHIP2 had no effect on basal PtdIns(3,4,5)P(3) levels, we show here that this lipid was significantly upregulated in …
Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid.
Uyttersprot N, Pelgrims N, Carrasco N, Gervy C, Maenhaut C, Dumont JE, Miot F. Uyttersprot N, et al. Among authors: dumont je. Mol Cell Endocrinol. 1997 Aug 8;131(2):195-203. doi: 10.1016/s0303-7207(97)00108-1. Mol Cell Endocrinol. 1997. PMID: 9296378
The hyperplasia of the chronically stimulated thyroid resulting from goitrogens/NaClO4 treatment was not modified by this short term treatment with KI. In contrast, KI decreased the weight of the total gland and the level of cell proliferation, as determined by the fractio …
The hyperplasia of the chronically stimulated thyroid resulting from goitrogens/NaClO4 treatment was not modified by this short term …
In vitro and in vivo regulation of thyrotropin receptor mRNA levels in dog and human thyroid cells.
Maenhaut C, Brabant G, Vassart G, Dumont JE. Maenhaut C, et al. Among authors: dumont je. J Biol Chem. 1992 Feb 15;267(5):3000-7. J Biol Chem. 1992. PMID: 1310679 Free article.
This up-regulation was confirmed at the protein level: forskolin-treated cells showed an enhanced cAMP response to TSH and an increased binding of labeled TSH to their membranes. Long term TSH treatment led to a slight down-regulation of TSHr mRNA in dog thyrocytes, but in …
This up-regulation was confirmed at the protein level: forskolin-treated cells showed an enhanced cAMP response to TSH and an increased bind …
Intermediate filaments in normal thyrocytes: modulation of vimentin expression in primary cultures.
Coclet J, Lamy F, Rickaert F, Dumont JE, Roger PP. Coclet J, et al. Among authors: dumont je. Mol Cell Endocrinol. 1991 Apr;76(1-3):135-48. doi: 10.1016/0303-7207(91)90268-w. Mol Cell Endocrinol. 1991. PMID: 1726489
In dog thyrocyte primary cultures, the antagonistic effects of thyrotropin (TSH) and epidermal growth factor (EGF) on differentiation expression were accompagnied by distinct long-term morphological changes: TSH-treated cells showed an epitheloid morphology; EGF reversibly …
In dog thyrocyte primary cultures, the antagonistic effects of thyrotropin (TSH) and epidermal growth factor (EGF) on differentiation expres …
Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture.
Roger PP, Reuse S, Servais P, Van Heuverswyn B, Dumont JE. Roger PP, et al. Among authors: dumont je. Cancer Res. 1986 Feb;46(2):898-906. Cancer Res. 1986. PMID: 3000588
TPA also inhibited the expression of differentiation stimulated by dibutyryl cyclic adenosine 3':5'-monophosphate indicating a post-cyclic adenosine 3':5'-monophosphate site of action. TPA and EGF shared long-term morphological effects such as the induction of an elongated …
TPA also inhibited the expression of differentiation stimulated by dibutyryl cyclic adenosine 3':5'-monophosphate indicating a post-cyclic a …
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