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Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis.
Foster MA, Bentley C, Hazeldine J, Acharjee A, Nahman O, Shen-Orr SS, Lord JM, Duggal NA. Foster MA, et al. Among authors: duggal na. Immun Ageing. 2022 Dec 5;19(1):60. doi: 10.1186/s12979-022-00317-5. Immun Ageing. 2022. PMID: 36471343 Free PMC article.
Reversing this aged immune system is likely to have a beneficial impact on short- and longer-term outcomes of trauma survivors....
Reversing this aged immune system is likely to have a beneficial impact on short- and longer-term outcomes of trauma survivors....
Multisystem physiological perspective of human frailty and its modulation by physical activity.
Taylor JA, Greenhaff PL, Bartlett DB, Jackson TA, Duggal NA, Lord JM. Taylor JA, et al. Among authors: duggal na. Physiol Rev. 2023 Apr 1;103(2):1137-1191. doi: 10.1152/physrev.00037.2021. Epub 2022 Oct 14. Physiol Rev. 2023. PMID: 36239451 Free PMC article. Review.
"Frailty" is a term used to refer to a state characterized by enhanced vulnerability to, and impaired recovery from, stressors compared with a nonfrail state, which is increasingly viewed as a loss of resilience. ...
"Frailty" is a term used to refer to a state characterized by enhanced vulnerability to, and impaired recovery from, stressors compar …
Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol: dehydroepiandrosterone sulphate ratio.
Phillips AC, Upton J, Duggal NA, Carroll D, Lord JM. Phillips AC, et al. Among authors: duggal na. BMC Geriatr. 2013 Jun 17;13:60. doi: 10.1186/1471-2318-13-60. BMC Geriatr. 2013. PMID: 23773910 Free PMC article.
CONCLUSION: Depression following hip fracture is associated with greater physical frailty and poorer long term recovery post-injury. Our data indicate that the underlying mechanisms may include an increased cortisol:DHEAS ratio and suggest that correcting this ratio for ex …
CONCLUSION: Depression following hip fracture is associated with greater physical frailty and poorer long term recovery post-injury. …