Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform.
Whyte W, Goswami D, Wang SX, Fan Y, Ward NA, Levey RE, Beatty R, Robinson ST, Sheppard D, O'Connor R, Monahan DS, Trask L, Mendez KL, Varela CE, Horvath MA, Wylie R, O'Dwyer J, Domingo-Lopez DA, Rothman AS, Duffy GP, Dolan EB, Roche ET.
Whyte W, et al. Among authors: duffy gp.
Nat Commun. 2022 Aug 3;13(1):4496. doi: 10.1038/s41467-022-32147-w.
Nat Commun. 2022.
PMID: 35922421
Free PMC article.
Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal control is necessary. ...Firstly, daily intermitte …
Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long- …