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Soft robot-mediated autonomous adaptation to fibrotic capsule formation for improved drug delivery.
Beatty R, Mendez KL, Schreiber LHJ, Tarpey R, Whyte W, Fan Y, Robinson ST, O'Dwyer J, Simpkin AJ, Tannian J, Dockery P, Dolan EB, Roche ET, Duffy GP. Beatty R, et al. Among authors: duffy gp. Sci Robot. 2023 Aug 30;8(81):eabq4821. doi: 10.1126/scirobotics.abq4821. Epub 2023 Aug 30. Sci Robot. 2023. PMID: 37647382
Informed by real-time sensor signals, this device offers the potential for long-term efficacy and sustained drug dosing, even in the setting of fibrotic capsule formation....
Informed by real-time sensor signals, this device offers the potential for long-term efficacy and sustained drug dosing, even in the …
Early Tibial Component Fractures in a Cementless, 3D-Printed, Titanium Implant.
Lam AD, Duffy GP. Lam AD, et al. Among authors: duffy gp. Arthroplast Today. 2022 Oct 12;18:31-38. doi: 10.1016/j.artd.2022.08.002. eCollection 2022 Dec. Arthroplast Today. 2022. PMID: 36267394 Free PMC article.
Fracture of the tibial baseplate in total knee arthroplasty is a rare occurrence, particularly in short- and mid-term follow-up. This case series documents the first known report in the literature of fatigue fracture of a cementless, 3D-printed, highly porous titanium tibi …
Fracture of the tibial baseplate in total knee arthroplasty is a rare occurrence, particularly in short- and mid-term follow-up. This …
Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform.
Whyte W, Goswami D, Wang SX, Fan Y, Ward NA, Levey RE, Beatty R, Robinson ST, Sheppard D, O'Connor R, Monahan DS, Trask L, Mendez KL, Varela CE, Horvath MA, Wylie R, O'Dwyer J, Domingo-Lopez DA, Rothman AS, Duffy GP, Dolan EB, Roche ET. Whyte W, et al. Among authors: duffy gp. Nat Commun. 2022 Aug 3;13(1):4496. doi: 10.1038/s41467-022-32147-w. Nat Commun. 2022. PMID: 35922421 Free PMC article.
Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal control is necessary. ...Firstly, daily intermitte …
Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long- …
A method of characterising the complex anatomy of vascular occlusions and 3D printing biomimetic analogues.
O'Reilly M, Beatty R, McBride S, Brennan B, Dockery P, Duffy GP. O'Reilly M, et al. Among authors: duffy gp. J Anat. 2023 Jan;242(1):64-75. doi: 10.1111/joa.13648. Epub 2022 Mar 7. J Anat. 2023. PMID: 35255526 Free PMC article.
Currently, few medical devices can effectively treat CTOs long-term, with amputation often required. This is due to a lack of knowledge of CTO anatomy, making device design and testing difficult. ...
Currently, few medical devices can effectively treat CTOs long-term, with amputation often required. This is due to a lack of knowled …
Assessing the Effects of VEGF Releasing Microspheres on the Angiogenic and Foreign Body Response to a 3D Printed Silicone-Based Macroencapsulation Device.
Levey RE, Coulter FB, Scheiner KC, Deotti S, Robinson ST, McDonough L, Nguyen TT, Steendam R, Canney M, Wylie R, Burke LP, Dolan EB, Dockery P, Kelly HM, Ghersi G, Hennink WE, Kok RJ, O'Cearbhaill E, Duffy GP. Levey RE, et al. Among authors: duffy gp. Pharmaceutics. 2021 Dec 4;13(12):2077. doi: 10.3390/pharmaceutics13122077. Pharmaceutics. 2021. PMID: 34959358 Free PMC article.
The development of neovascularization adjacent to the device is vital for the survival of encapsulated islets and is a limitation for long-term device success. Previously we developed additive manufactured multi-scale porosity implants, which demonstrated a 2.5-fold increa …
The development of neovascularization adjacent to the device is vital for the survival of encapsulated islets and is a limitation for long- …
The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model.
Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP. Beatty R, et al. Among authors: duffy gp. Tissue Eng Part C Methods. 2021 Oct;27(10):515-528. doi: 10.1089/ten.TEC.2021.0163. Tissue Eng Part C Methods. 2021. PMID: 34541880
The move toward a bioartificial pancreas and other fully implantable systems could help restore patient's glycemic control. However, the long-term success of implantable medical devices is often hindered by the foreign body response. ...
The move toward a bioartificial pancreas and other fully implantable systems could help restore patient's glycemic control. However, the lon …
Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes.
Goswami D, Domingo-Lopez DA, Ward NA, Millman JR, Duffy GP, Dolan EB, Roche ET. Goswami D, et al. Among authors: duffy gp. Adv Sci (Weinh). 2021 Aug;8(16):e2100820. doi: 10.1002/advs.202100820. Epub 2021 Jun 21. Adv Sci (Weinh). 2021. PMID: 34155834 Free PMC article. Review.
Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long-term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is t …
Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation cu …
Sustained Release of Vascular Endothelial Growth Factor from Poly(ε-caprolactone-PEG-ε-caprolactone)-b-Poly(l-lactide) Multiblock Copolymer Microspheres.
Scheiner KC, Maas-Bakker RF, Nguyen TT, Duarte AM, Hendriks G, Sequeira L, Duffy GP, Steendam R, Hennink WE, Kok RJ. Scheiner KC, et al. Among authors: duffy gp. ACS Omega. 2019 Jul 1;4(7):11481-11492. doi: 10.1021/acsomega.9b01272. eCollection 2019 Jul 31. ACS Omega. 2019. PMID: 31460253 Free PMC article.
Such applications require sustained local delivery of VEGF of around 4 weeks for stable blood vessel formation. Most delivery systems for VEGF only provide short-term release for a couple of days, followed by a release phase with very low VEGF release. ...These microsphere …
Such applications require sustained local delivery of VEGF of around 4 weeks for stable blood vessel formation. Most delivery systems for VE …
An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure.
Curley CJ, Dolan EB, Otten M, Hinderer S, Duffy GP, Murphy BP. Curley CJ, et al. Among authors: duffy gp. Drug Deliv Transl Res. 2019 Feb;9(1):1-13. doi: 10.1007/s13346-018-00601-2. Drug Deliv Transl Res. 2019. PMID: 30511249
As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional stabilisation and improvement in heart function post MI …
As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising signi …
Optimum parameters for freeze-drying decellularized arterial scaffolds.
Sheridan WS, Duffy GP, Murphy BP. Sheridan WS, et al. Among authors: duffy gp. Tissue Eng Part C Methods. 2013 Dec;19(12):981-90. doi: 10.1089/ten.TEC.2012.0741. Epub 2013 Jun 25. Tissue Eng Part C Methods. 2013. PMID: 23614758 Free PMC article.
Decellularized arterial scaffolds have achieved success in advancing toward clinical use as vascular grafts. However, concerns remain regarding long-term preservation and sterilization of these scaffolds. Freeze drying offers a means of overcoming these concerns. ...
Decellularized arterial scaffolds have achieved success in advancing toward clinical use as vascular grafts. However, concerns remain regard …
13 results