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Characterization of agonist-induced motilin receptor trafficking and its implications for tachyphylaxis.
Lamian V, Rich A, Ma Z, Li J, Seethala R, Gordon D, Dubaquie Y. Lamian V, et al. Among authors: dubaquie y. Mol Pharmacol. 2006 Jan;69(1):109-18. doi: 10.1124/mol.105.017111. Epub 2005 Oct 12. Mol Pharmacol. 2006. PMID: 16221873
Motilin, the natural MR peptide ligand, has profound stimulatory effects on gastrointestinal contractility, indicating a therapeutic potential for MR modulators. However, long-term clinical use of certain MR agonists is limited by tachyphylaxis, a reduced responsiveness to …
Motilin, the natural MR peptide ligand, has profound stimulatory effects on gastrointestinal contractility, indicating a therapeutic potenti …