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Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines.
Bond ST, Zhuang A, Yang C, Gould EAM, Sikora T, Liu Y, Fu Y, Watt KI, Tan Y, Kiriazis H, Lancaster GI, Gregorevic P, Henstridge DC, McMullen JR, Meikle PJ, Calkin AC, Drew BG. Bond ST, et al. Among authors: drew bg. Mol Metab. 2021 Nov;53:101292. doi: 10.1016/j.molmet.2021.101292. Epub 2021 Jul 8. Mol Metab. 2021. PMID: 34246805 Free PMC article.
The advantages of this technology are many fold, however some questions still remain regarding the effects that long term expression of foreign proteins such as Cas9, have on mammalian cell function. ...
The advantages of this technology are many fold, however some questions still remain regarding the effects that long term expression …
Management of Hypothermia in Tactical Combat Casualty Care: TCCC Guideline Proposed Change 20-01 (June 2020).
Bennett BL, Giesbrect G, Zafren K, Christensen R, Littlejohn LF, Drew B, Cap AP, Miles EA, Butler FK Jr, Holcomb JB, Shackelford SA. Bennett BL, et al. Among authors: drew b. J Spec Oper Med. 2020 Fall;20(3):21-35. doi: 10.55460/QQ9R-RR8A. J Spec Oper Med. 2020. PMID: 32969001 Review.
Consequently, based on lessons learned, some US Special Operations Forces are now upgrading the HPMK after short-term use (60 minutes) by adding insulation around the casualty during training in cold environments. ...
Consequently, based on lessons learned, some US Special Operations Forces are now upgrading the HPMK after short-term use (60 minutes …
Discrepancies Between Patient and Surgeon Expectations of Surgery for Sciatica: A Challenge for Informed Decision Making?
Rehman Y, Syed M, Wiercioch W, Rehman N, Drew B, Cenic A, Reddy K, Murty N, Kucher E, Dunlop B, Guyatt GH, Busse JW, Schwartz L, Vanstone M. Rehman Y, et al. Among authors: drew b. Spine (Phila Pa 1976). 2019 May 15;44(10):740-746. doi: 10.1097/BRS.0000000000002914. Spine (Phila Pa 1976). 2019. PMID: 30395083
Surgeons and patients disagreed on how much information is needed about postsurgical activity modifications and long-term outcomes to make a decision about whether or not to undergo surgery, with patients desiring more information. ...
Surgeons and patients disagreed on how much information is needed about postsurgical activity modifications and long-term outcomes to …
A systematic review assessing non-pharmacological conservative treatment studies for people with non-inflammatory multi-joint pain: clinical outcomes and research design considerations.
Comer C, Smith TO, Drew B, Raja R, Kingsbury SR, Conaghan PG. Comer C, et al. Among authors: drew b. Rheumatol Int. 2018 Mar;38(3):331-341. doi: 10.1007/s00296-017-3876-1. Epub 2017 Nov 16. Rheumatol Int. 2018. PMID: 29147758 Free PMC article. Review.
All interventions significantly improved pain, function and quality of life in the short-term. There was limited reporting of measures for absenteeism, presenteeism and psychosocial outcomes. ...
All interventions significantly improved pain, function and quality of life in the short-term. There was limited reporting of measure …
Knee orthoses for treating patellofemoral pain syndrome.
Smith TO, Drew BT, Meek TH, Clark AB. Smith TO, et al. Among authors: drew bt. Cochrane Database Syst Rev. 2015 Dec 8;2015(12):CD010513. doi: 10.1002/14651858.CD010513.pub2. Cochrane Database Syst Rev. 2015. PMID: 26645724 Free PMC article. Review.
There is very low quality evidence of no clinically important differences between the two groups in short-term (2 to 12 weeks follow-up) knee pain based on the visual analogue scale (0 to 10 points; higher scores mean worse pain): MD -0.46 favouring knee orthoses, 95% CI - …
There is very low quality evidence of no clinically important differences between the two groups in short-term (2 to 12 weeks follow- …
Normal prehospital electrocardiography is linked to long-term survival in patients presenting to the emergency department with symptoms of acute coronary syndrome.
Zègre-Hemsey JK, Sommargren CE, Asafu-Adjei JK, Drew BJ. Zègre-Hemsey JK, et al. Among authors: drew bj. J Electrocardiol. 2015 Jul-Aug;48(4):520-6. doi: 10.1016/j.jelectrocard.2015.01.014. Epub 2015 Feb 2. J Electrocardiol. 2015. PMID: 25683824 Free PMC article.
They experienced significantly less adverse hospital outcomes (12% vs 37%), length of stay (1.19 vs 3.86 days), and long-term mortality (9% vs 28%) than those with any PH ECG abnormality (p<.05). CONCLUSION: Normal PH ECG findings are associated with better short and lo …
They experienced significantly less adverse hospital outcomes (12% vs 37%), length of stay (1.19 vs 3.86 days), and long-term mortali …
Minimally invasive versus open surgery for cervical and lumbar discectomy: a systematic review and meta-analysis.
Evaniew N, Khan M, Drew B, Kwok D, Bhandari M, Ghert M. Evaniew N, et al. Among authors: drew b. CMAJ Open. 2014 Oct 1;2(4):E295-305. doi: 10.9778/cmajo.20140048. eCollection 2014 Oct. CMAJ Open. 2014. PMID: 25485257 Free PMC article.
We found that minimally invasive surgery did not improve long-term function (cervical: SMD 0.11, 95% confidence interval [CI] -0.09 to 0.31; lumbar: SMD 0.04, 95% CI -0.11 to 0.20) or reduce long-term extremity pain (cervical: SMD -0.21, 95% CI -0.52 to 0.10; lumbar …
We found that minimally invasive surgery did not improve long-term function (cervical: SMD 0.11, 95% confidence interval [CI] -0.09 t …
Edoxaban versus warfarin in patients with atrial fibrillation.
Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators. Giugliano RP, et al. N Engl J Med. 2013 Nov 28;369(22):2093-104. doi: 10.1056/NEJMoa1310907. Epub 2013 Nov 19. N Engl J Med. 2013. PMID: 24251359 Free article. Clinical Trial.
BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. ...
BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of ed …
Prevalence of abuse and intimate partner violence surgical evaluation (PRAISE) in orthopaedic fracture clinics: a multinational prevalence study.
PRAISE Investigators; Sprague S, Bhandari M, Della Rocca GJ, Goslings JC, Poolman RW, Madden K, Simunovic N, Dosanjh S, Schemitsch EH. PRAISE Investigators, et al. Lancet. 2013 Sep 7;382(9895):866-76. doi: 10.1016/S0140-6736(13)61205-2. Epub 2013 Jun 12. Lancet. 2013. PMID: 23768757
One in six women (455/2839, 16.0%, 95% CI 14.7-17.4%) disclosed a history of IPV within the past year, and one in three (882/2550, 34.6%, 32.8-36.5%) had experienced IPV in their lifetime. 49 women (1.7%, 1.3-2.2%) attended their clinic visit as a direct consequence of IPV, only …
One in six women (455/2839, 16.0%, 95% CI 14.7-17.4%) disclosed a history of IPV within the past year, and one in three (882/2550, 34.6%, 32 …
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