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Selection of excipient, solvent and packaging to optimize the performance of spray-dried formulations: case example fenofibrate.
Hugo M, Kunath K, Dressman J. Hugo M, et al. Among authors: dressman j. Drug Dev Ind Pharm. 2013 Feb;39(2):402-12. doi: 10.3109/03639045.2012.685176. Epub 2012 May 17. Drug Dev Ind Pharm. 2013. PMID: 22591213
RESULTS AND DISCUSSION: Spray drying the same formulation from two different solvents led to different physicochemical properties, dissolution behavior and long-term stability. The dissolution behavior and long-term stability also varied significantly among excipien …
RESULTS AND DISCUSSION: Spray drying the same formulation from two different solvents led to different physicochemical properties, dissoluti …
Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update.
Jantratid E, Janssen N, Reppas C, Dressman JB. Jantratid E, et al. Among authors: dressman jb. Pharm Res. 2008 Jul;25(7):1663-76. doi: 10.1007/s11095-008-9569-4. Epub 2008 Apr 11. Pharm Res. 2008. PMID: 18404251
PURPOSE: The aim of this study was to update the compositions of biorelevant media to represent the composition and physical chemical characteristics of the gastrointestinal fluids as closely as possible while providing physical stability during dissolution runs and short-term …
PURPOSE: The aim of this study was to update the compositions of biorelevant media to represent the composition and physical chemical charac …
Mixing-tank model for predicting dissolution rate control or oral absorption.
Dressman JB, Fleisher D. Dressman JB, et al. J Pharm Sci. 1986 Feb;75(2):109-16. doi: 10.1002/jps.2600750202. J Pharm Sci. 1986. PMID: 3958917
The model is developed from mass balance considerations in which the nonsink dissolution term is a function of the remaining surface area and the concentration gradient across the boundary layer. ...
The model is developed from mass balance considerations in which the nonsink dissolution term is a function of the remaining surface …