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Maturation of lipid metabolism in the fetal and newborn sheep heart.
Drake RR, Louey S, Thornburg KL. Drake RR, et al. Am J Physiol Regul Integr Comp Physiol. 2023 Dec 1;325(6):R809-R819. doi: 10.1152/ajpregu.00122.2023. Epub 2023 Oct 23. Am J Physiol Regul Integr Comp Physiol. 2023. PMID: 37867472
At birth, the fetus experiences a dramatic change in environment that is accompanied by a shift in myocardial fuel preference from lactate and glucose in fetal life to fatty acid oxidation after birth. We hypothesized that fatty acid metabolic machinery would mature …
At birth, the fetus experiences a dramatic change in environment that is accompanied by a shift in myocardial fuel preference from la …
Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart.
Drake RR, Louey S, Thornburg KL. Drake RR, et al. J Physiol. 2022 Feb;600(3):655-670. doi: 10.1113/JP281415. Epub 2021 Dec 13. J Physiol. 2022. PMID: 34802149 Free PMC article.
At birth, the mammalian myocardium switches from using carbohydrates as the primary energy substrate to free fatty acids as the primary fuel. ...Mismatches in gene and protein expression, and increased circulating fatty acylcarnitines may have long-term implications …
At birth, the mammalian myocardium switches from using carbohydrates as the primary energy substrate to free fatty acids as the prima …
Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes.
Lindgren IM, Drake RR, Chattergoon NN, Thornburg KL. Lindgren IM, et al. Among authors: drake rr. FASEB J. 2019 Jun;33(6):7417-7426. doi: 10.1096/fj.201801330RR. Epub 2019 Mar 18. FASEB J. 2019. PMID: 30884246 Free PMC article.
Fetal cardiomyocytes shift from glycolysis to oxidative phosphorylation around the time of birth. Myeloid ecotropic viral integration site 1 (MEIS1) is a transcription factor that promotes glycolysis in hematopoietic stem cells. ...We hypothesized that suppression of MEIS1 …
Fetal cardiomyocytes shift from glycolysis to oxidative phosphorylation around the time of birth. Myeloid ecotropic viral integration …
Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture.
Baatz JE, Newton DA, Riemer EC, Denlinger CE, Jones EE, Drake RR, Spyropoulos DD. Baatz JE, et al. Among authors: drake rr. In Vivo. 2014 Jul-Aug;28(4):411-23. In Vivo. 2014. PMID: 24982205 Free PMC article.
Expansion-perfusion rates, volumes and cryoprotectant formulation were optimized to maintain tissue architecture, decrease crystal formation and increase long-term cell viability. Rates of expansion of 4 cc/min or less and volumes ranging from 0.8-1.2 tissue volume were we …
Expansion-perfusion rates, volumes and cryoprotectant formulation were optimized to maintain tissue architecture, decrease crystal formation …
The identification of serum biomarkers of high-let radiation exposure and biological sequelae.
Britten RA, Mitchell S, Johnson AM, Singletary SJ, Keeney SK, Nyalwidhe JO, Karbassi ID, Lonart G, Sanford LD, Drake RR. Britten RA, et al. Among authors: drake rr. Health Phys. 2010 Feb;98(2):196-203. doi: 10.1097/HP.0b013e3181acff7c. Health Phys. 2010. PMID: 20065683
In the event of a nuclear detonation, thousands of people will be exposed to non-lethal radiation doses. There are multiple long-term health concerns for exposed individuals who receive non-lethal radiation exposures. ...The identification of serum biomarkers that can be u …
In the event of a nuclear detonation, thousands of people will be exposed to non-lethal radiation doses. There are multiple long-term …
Differential capture of serum proteins for expression profiling and biomarker discovery in pre- and posttreatment head and neck cancer samples.
Freed GL, Cazares LH, Fichandler CE, Fuller TW, Sawyer CA, Stack BC Jr, Schraff S, Semmes OJ, Wadsworth JT, Drake RR. Freed GL, et al. Among authors: drake rr. Laryngoscope. 2008 Jan;118(1):61-8. doi: 10.1097/MLG.0b013e31814cf389. Laryngoscope. 2008. PMID: 18043497
INTRODUCTION: A long-term goal of our group is to develop proteomic-based approaches to the detection and use of protein biomarkers for improvement in diagnosis, prognosis, and tailoring of treatment for head and neck squamous cell cancer (HNSCC). ...
INTRODUCTION: A long-term goal of our group is to develop proteomic-based approaches to the detection and use of protein biomarkers f …
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.
Mao F, Rechtin TM, Jones R, Cantu AA, Anderson LS, Radominska A, Moyer MP, Drake RR. Mao F, et al. Among authors: drake rr. J Biol Chem. 1995 Jun 9;270(23):13660-4. doi: 10.1074/jbc.270.23.13660. J Biol Chem. 1995. PMID: 7775417 Free article.
Long term administration of 3'-azidothymidine (AZT) for the treatment of AIDS has led to detrimental clinical side effects in some patients, the biochemical causes of which are still being delineated. ...
Long term administration of 3'-azidothymidine (AZT) for the treatment of AIDS has led to detrimental clinical side effects in some pa …