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Novel Textbook Outcomes following emergency laparotomy: Delphi exercise.
Naumann DN, Bhangu A, Brooks A, Martin M, Cotton BA, Khan M, Midwinter MJ, Pearce L, Bowley DM, Holcomb JB, Griffiths EA; BEACON Collaborative. Naumann DN, et al. BJS Open. 2024 Jan 3;8(1):zrad145. doi: 10.1093/bjsopen/zrad145. BJS Open. 2024. PMID: 38284399 Free PMC article.
The final Textbook Outcomes were divided into 'early' and 'longer-term'. For non-trauma patients the proposed early Textbook Outcome was 'Discharged from hospital without serious postoperative complications (Clavien-Dindo grade III; including intra-abdominal sepsis, organ …
The final Textbook Outcomes were divided into 'early' and 'longer-term'. For non-trauma patients the proposed early Textbook Outcome …
Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma.
Westin JR, Oluwole OO, Kersten MJ, Miklos DB, Perales MA, Ghobadi A, Rapoport AP, Sureda A, Jacobson CA, Farooq U, van Meerten T, Ulrickson M, Elsawy M, Leslie LA, Chaganti S, Dickinson M, Dorritie K, Reagan PM, McGuirk J, Song KW, Riedell PA, Minnema MC, Yang Y, Vardhanabhuti S, Filosto S, Cheng P, Shahani SA, Schupp M, To C, Locke FL; ZUMA-7 Investigators; Kite Members. Westin JR, et al. N Engl J Med. 2023 Jul 13;389(2):148-157. doi: 10.1056/NEJMoa2301665. Epub 2023 Jun 5. N Engl J Med. 2023. PMID: 37272527 Clinical Trial.
BACKGROUND: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma who received axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor T-cell therapy, as second-line treatment had …
BACKGROUND: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma wh …
Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children.
Hall NJ, Sherratt FC, Eaton S, Walker E, Chorozoglou M, Beasant L, Stanton M, Corbett H, Rex D, Hutchings N, Dixon E, Crawley E, Blazeby J, Young B, Reading I. Hall NJ, et al. Among authors: dixon e. BMJ Paediatr Open. 2023 Feb;7(1):e001673. doi: 10.1136/bmjpo-2022-001673. BMJ Paediatr Open. 2023. PMID: 36746524 Free PMC article. Clinical Trial.
Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorter duration of requiring analgesia, more rapid return to normal activities and shorter parental absence from work. ...
Compared with appendicectomy, children allocated to non-operative treatment reported higher short-term quality of life scores, shorte …
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing liver resection: protocol for the haemorrhage during liver resection tranexamic acid (HeLiX) randomised controlled trial.
Karanicolas PJ, Lin Y, McCluskey S, Roke R, Tarshis J, Thorpe KE, Ball CG, Chaudhury P, Cleary SP, Dixon E, Eeson G, Moulton CA, Nanji S, Porter G, Ruo L, Skaro AI, Tsang M, Wei AC, Guyatt G; HepatoPancreaticoBiliary Community of Surgical ONcologists: Clinical, Evaluative, and Prospective Trials (HPB CONCEPT) Team. Karanicolas PJ, et al. Among authors: dixon e. BMJ Open. 2022 Feb 24;12(2):e058850. doi: 10.1136/bmjopen-2021-058850. BMJ Open. 2022. PMID: 35210348 Free PMC article.
Extensive intraoperative blood loss is a major risk factor for postoperative morbidity and mortality and receipt of blood transfusion is associated with serious risks including an association with long-term cancer recurrence and overall survival. In addition, blood product …
Extensive intraoperative blood loss is a major risk factor for postoperative morbidity and mortality and receipt of blood transfusion is ass …
A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT.
Daniels J, Dixon EF, Gill A, Bishop J, D'Amico M, Ahmed K, Dodds J, Tryposkiadis K, Wilks M, Millar M, Husain S, Gray J, Whiley A, Moore PV, Munetsi RL, Hemming K, Roberts T, Plumb J, Deeks J, Khan KS, Thangaratinam S. Daniels J, et al. Among authors: dixon ef. Health Technol Assess. 2022 Feb;26(12):1-82. doi: 10.3310/BICF1187. Health Technol Assess. 2022. PMID: 35195519 Free article. Clinical Trial.
PARTICIPANTS: Vaginal and rectal swabs were taken from women with risk factors for vertical group B Streptococcus transmission in established term labour. The accuracy of the GeneXpert() Dx IV GBS rapid testing system (Cepheid, Maurens-Scopont, France) was compared with th …
PARTICIPANTS: Vaginal and rectal swabs were taken from women with risk factors for vertical group B Streptococcus transmission in establishe …
Deprescribing montelukast in children with asthma: a systematic review.
Dixon EG, King C, Lilley A, Sinha IP, Hawcutt DB. Dixon EG, et al. BMJ Open. 2022 Jan 31;12(1):e053112. doi: 10.1136/bmjopen-2021-053112. BMJ Open. 2022. PMID: 35105629 Free PMC article.
Significant differences between the comparator points within the test group were found in nine outcomes across four studies; FEV1/forced vital capacity, FEV1, forced expiratory flows (25%-75%), asthma score (study specific), maximum % fall in FEV1 and time to recovery (post exerc …
Significant differences between the comparator points within the test group were found in nine outcomes across four studies; FEV1/forced vit …
Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study.
Daniels JP, Dixon E, Gill A, Bishop J, Wilks M, Millar M, Gray J, Roberts TE, Plumb J, Deeks JJ, Hemming K, Khan KS, Thangaratinam S; GBS2 Collaborative Group. Daniels JP, et al. Among authors: dixon e. BMC Med. 2022 Jan 14;20(1):9. doi: 10.1186/s12916-021-02202-2. BMC Med. 2022. PMID: 35027057 Free PMC article. Clinical Trial.
Within units assigned to rapid testing, vaginal-rectal swabs were taken from women with risk factors for vertical GBS transmission in established term labour. The trial primary outcome was the proportion of women receiving intrapartum antibiotics to prevent neonatal early- …
Within units assigned to rapid testing, vaginal-rectal swabs were taken from women with risk factors for vertical GBS transmission in establ …
Pathophysiological mechanisms of liver injury in COVID-19.
Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M. Nardo AD, et al. Among authors: dixon ed. Liver Int. 2021 Jan;41(1):20-32. doi: 10.1111/liv.14730. Epub 2020 Nov 29. Liver Int. 2021. PMID: 33190346 Free PMC article. Review.
This concise review discusses the potential pathophysiological mechanisms for SARS-CoV-2 hepatic tropism as well as acute and possibly long-term liver injury in COVID-19....
This concise review discusses the potential pathophysiological mechanisms for SARS-CoV-2 hepatic tropism as well as acute and possibly long- …
44 results