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Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
Ryu S, Spadaro O, Sidorov S, Lee AH, Caprio S, Morrison C, Smith SR, Ravussin E, Shchukina I, Artyomov MN, Youm YH, Dixit VD. Ryu S, et al. Among authors: dixit vd. J Clin Invest. 2023 Oct 2;133(19):e169173. doi: 10.1172/JCI169173. J Clin Invest. 2023. PMID: 37781916 Free PMC article.
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. ...
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established t …
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue.
Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. Goldberg EL, et al. Among authors: dixit vd. Nat Metab. 2020 Jan;2(1):50-61. doi: 10.1038/s42255-019-0160-6. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 32694683 Free PMC article.
Here, by using single-cell RNA sequencing of adipose-tissue-resident immune cells, we show that KD expands metabolically protective gammadelta T cells that restrain inflammation. Notably, long-term ad libitum KD feeding in mice causes obesity, impairs metabolic health and …
Here, by using single-cell RNA sequencing of adipose-tissue-resident immune cells, we show that KD expands metabolically protective gammadel …
Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.
Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. Meydani SN, et al. Among authors: dixit vd. Aging (Albany NY). 2016 Jul;8(7):1416-31. doi: 10.18632/aging.100994. Aging (Albany NY). 2016. PMID: 27410480 Free PMC article. Clinical Trial.
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function i …
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR …
Metabolically healthy and unhealthy obese--the 2013 Stock Conference report.
Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen KH, Rabasa-Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E. Samocha-Bonet D, et al. Among authors: dixit vd. Obes Rev. 2014 Sep;15(9):697-708. doi: 10.1111/obr.12199. Epub 2014 Jul 25. Obes Rev. 2014. PMID: 25059108 Free PMC article. Review.
However, the main obstacle in advancing our understanding of the metabolically healthy obese phenotype and its related long-term health risks is the lack of a standardized definition. Here, we summarize the proceedings of the 13th Stock Conference of the International Asso …
However, the main obstacle in advancing our understanding of the metabolically healthy obese phenotype and its related long-term heal …
Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage.
Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD. Youm YH, et al. Among authors: dixit vd. Endocrinology. 2011 Nov;152(11):4039-45. doi: 10.1210/en.2011-1326. Epub 2011 Aug 23. Endocrinology. 2011. PMID: 21862613 Free PMC article.
Furthermore, elimination of NLRP3 inflammasome protected the pancreatic beta-cells from cell death caused by long-term high-fat feeding during obesity with significant increase in the size of the islets of Langerhans. ...
Furthermore, elimination of NLRP3 inflammasome protected the pancreatic beta-cells from cell death caused by long-term high-fat feedi …
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance.
Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, Greenway F, Stephens JM, Mynatt RL, Dixit VD. Yang H, et al. Among authors: dixit vd. J Immunol. 2010 Aug 1;185(3):1836-45. doi: 10.4049/jimmunol.1000021. Epub 2010 Jun 25. J Immunol. 2010. PMID: 20581149 Free PMC article.
; 2) Do the extralymphoid ARTs possess a unique TCR repertoire compared with lymphoid-resident T cells and whether obesity alters the TCR diversity in specific adipose depots?; and 3) Does short-term elimination of T cells in epididymal fat pad without disturbing the syste …
; 2) Do the extralymphoid ARTs possess a unique TCR repertoire compared with lymphoid-resident T cells and whether obesity alters the TCR di …
Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin levels during aging.
Yang H, Youm YH, Nakata C, Dixit VD. Yang H, et al. Among authors: dixit vd. Peptides. 2007 Oct;28(10):1931-6. doi: 10.1016/j.peptides.2007.07.030. Epub 2007 Aug 19. Peptides. 2007. PMID: 17875344 Free PMC article.
We also report for the first time that chronic CR during aging significantly increases circulating ghrelin levels as well as total ghrelin production in the stomach and reverses age-related loss of ghrelin receptor expression in pituitary. Our data suggests that long-term …
We also report for the first time that chronic CR during aging significantly increases circulating ghrelin levels as well as total ghrelin p …
Transport stress modulates adrenocorticotropin secretion from peripheral bovine lymphocytes.
Dixit VD, Marahrens M, Parvizi N. Dixit VD, et al. J Anim Sci. 2001 Mar;79(3):729-34. doi: 10.2527/2001.793729x. J Anim Sci. 2001. PMID: 11263834
The influence of transport stress on the secretion of adrenocorticotropin (ACTH) from peripheral bovine lymphocytes was evaluated by exposing cows to short- (30 min) or long-term (14 h) transport. After transporting animals for 14 h they were given a mandatory rest for 24 …
The influence of transport stress on the secretion of adrenocorticotropin (ACTH) from peripheral bovine lymphocytes was evaluated by exposin …