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A water-soluble tomato extract rich in secondary plant metabolites lowers trimethylamine-n-oxide and modulates gut microbiota: a randomized, double-blind, placebo-controlled cross-over study in overweight and obese adults.
Rehman A, Tyree SM, Fehlbaum S, DunnGalvin G, Panagos CG, Guy B, Patel S, Dinan TG, Duttaroy AK, Duss R, Steinert RE. Rehman A, et al. Among authors: dinan tg. J Nutr. 2023 Jan;153(1):96-105. doi: 10.1016/j.tjnut.2022.11.009. Epub 2022 Dec 23. J Nutr. 2023. PMID: 36913483 Free article. Clinical Trial.
This trial was registered at clinicaltrials.gov as NCT04160481 (https://clinicaltrials.gov/ct2/show/NCT04160481?term= Fruitflow&draw= 2&rank= 2)....
This trial was registered at clinicaltrials.gov as NCT04160481 (https://clinicaltrials.gov/ct2/show/NCT04160481?term= Fruitflow&d …
Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment.
Lynch CMK, Cowan CSM, Bastiaanssen TFS, Moloney GM, Theune N, van de Wouw M, Florensa Zanuy E, Ventura-Silva AP, Codagnone MG, Villalobos-Manríquez F, Segalla M, Koc F, Stanton C, Ross P, Dinan TG, Clarke G, Cryan JF. Lynch CMK, et al. Among authors: dinan tg. Brain Behav Immun. 2023 Feb;108:309-327. doi: 10.1016/j.bbi.2022.12.008. Epub 2022 Dec 17. Brain Behav Immun. 2023. PMID: 36535610 Free article.
Epidemiological studies have shown that early-life antibiotic exposure can increase an individual's risk of developing immune and metabolic diseases. Moreover, preclinical studies have shown that long-term antibiotic-induced microbial disruption in early life can have endu …
Epidemiological studies have shown that early-life antibiotic exposure can increase an individual's risk of developing immune and metabolic …
The effect of exercise interventions on inflammatory markers in major depressive disorder: protocol for a systematic review and meta-analysis.
Grunberg D, Martin JA, Cryan JF, O'Halloran KD, Kelleher E, Dinan TG, Clarke G. Grunberg D, et al. Among authors: dinan tg. HRB Open Res. 2022 Jun 15;4:42. doi: 10.12688/hrbopenres.13240.3. eCollection 2021. HRB Open Res. 2022. PMID: 36263316 Free PMC article.
Methods: Electronic databases (APA PsycINFO, and PubMed/MEDLINE (EBSCO interface), EMBASE) will be searched using a detailed search strategy comprised of three search term themes: exercise, depression/MDD, and inflammation/inflammatory molecules. ...
Methods: Electronic databases (APA PsycINFO, and PubMed/MEDLINE (EBSCO interface), EMBASE) will be searched using a detailed search strategy …
Distinct post-sepsis induced neurochemical alterations in two mouse strains.
Browne CA, Clarke G, Fitzgerald P, O'Sullivan J, Dinan TG, Cryan JF. Browne CA, et al. Among authors: dinan tg. Brain Behav Immun. 2022 Aug;104:39-53. doi: 10.1016/j.bbi.2022.05.005. Epub 2022 May 13. Brain Behav Immun. 2022. PMID: 35569797
Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairment or global loss of cognitive function. Currently there is no clearly defined neurochemical basis of septic encephalopathy. ...
Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairm …
Altered stress responses in adults born by Caesarean section.
Dinan TG, Kennedy PJ, Morais LH, Murphy A, Long-Smith CM, Moloney GM, Bastiaanssen TFS, Allen AP, Collery A, Mullins D, Cusack AM, Berding K, O'Toole PW, Clarke G, Stanton C, Cryan JF. Dinan TG, et al. Neurobiol Stress. 2021 Dec 28;16:100425. doi: 10.1016/j.ynstr.2021.100425. eCollection 2022 Jan. Neurobiol Stress. 2021. PMID: 35024387 Free PMC article.
Birth by Caesarean-section (C-section), which increases the risk for metabolic and immune disorders, disrupts the normal initial microbial colonisation of the gut, in addition to preventing early priming of the stress and immune-systems.. Animal studies have shown there ar …
Birth by Caesarean-section (C-section), which increases the risk for metabolic and immune disorders, disrupts the normal initial micr …
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.
Sforzini L, Worrell C, Kose M, Anderson IM, Aouizerate B, Arolt V, Bauer M, Baune BT, Blier P, Cleare AJ, Cowen PJ, Dinan TG, Fagiolini A, Ferrier IN, Hegerl U, Krystal AD, Leboyer M, McAllister-Williams RH, McIntyre RS, Meyer-Lindenberg A, Miller AH, Nemeroff CB, Normann C, Nutt D, Pallanti S, Pani L, Penninx BWJH, Schatzberg AF, Shelton RC, Yatham LN, Young AH, Zahn R, Aislaitner G, Butlen-Ducuing F, Fletcher C, Haberkamp M, Laughren T, Mäntylä FL, Schruers K, Thomson A, Arteaga-Henríquez G, Benedetti F, Cash-Gibson L, Chae WR, De Smedt H, Gold SM, Hoogendijk WJG, Mondragón VJ, Maron E, Martynowicz J, Melloni E, Otte C, Perez-Fuentes G, Poletti S, Schmidt ME, van de Ketterij E, Woo K, Flossbach Y, Ramos-Quiroga JA, Savitz AJ, Pariante CM. Sforzini L, et al. Among authors: dinan tg. Mol Psychiatry. 2022 Mar;27(3):1286-1299. doi: 10.1038/s41380-021-01381-x. Epub 2021 Dec 15. Mol Psychiatry. 2022. PMID: 34907394 Free PMC article. Review.
Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse.
Morais LH, Golubeva AV, Casey S, Scott KA, Ramos Costa AP, Moloney GM, Dinan TG, Cryan JF. Morais LH, et al. Among authors: dinan tg. Neuropsychopharmacology. 2021 Oct;46(11):1958-1968. doi: 10.1038/s41386-021-01040-3. Epub 2021 May 26. Neuropsychopharmacology. 2021. PMID: 34040156 Free PMC article.
The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in …
The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the ae …
Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice.
O'Connor R, Moloney GM, Fulling C, O'Riordan KJ, Fitzgerald P, Bastiaanssen TFS, Schellekens H, Dinan TG, Cryan JF. O'Connor R, et al. Among authors: dinan tg. Behav Brain Res. 2021 Apr 23;404:113156. doi: 10.1016/j.bbr.2021.113156. Epub 2021 Feb 8. Behav Brain Res. 2021. PMID: 33571573 Free article.
This antibiotic use is necessary and beneficial in the short-term; however, long-term consequences on brain and behaviour have not been studied in detail. ...
This antibiotic use is necessary and beneficial in the short-term; however, long-term consequences on brain and behaviour have …
Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse.
Morais LH, Golubeva AV, Moloney GM, Moya-Pérez A, Ventura-Silva AP, Arboleya S, Bastiaanssen TFS, O'Sullivan O, Rea K, Borre Y, Scott KA, Patterson E, Cherry P, Stilling R, Hoban AE, El Aidy S, Sequeira AM, Beers S, Moloney RD, Renes IB, Wang S, Knol J, Ross RP, O'Toole PW, Cotter PD, Stanton C, Dinan TG, Cryan JF. Morais LH, et al. Among authors: dinan tg. Curr Biol. 2020 Oct 5;30(19):3761-3774.e6. doi: 10.1016/j.cub.2020.07.044. Epub 2020 Aug 20. Curr Biol. 2020. PMID: 32822606 Free article.
Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. ...Taken together, our data link the gut microbiota to behavioral alterations in C-section-born mice and suggest …
Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immun …
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
van de Wouw M, Walsh AM, Crispie F, van Leuven L, Lyte JM, Boehme M, Clarke G, Dinan TG, Cotter PD, Cryan JF. van de Wouw M, et al. Among authors: dinan tg. Microbiome. 2020 May 18;8(1):67. doi: 10.1186/s40168-020-00846-5. Microbiome. 2020. PMID: 32423436 Free PMC article.
Furthermore, UK4 increased fear-dependent contextual memory, yet decreased milk gavage-induced improvements in long-term spatial learning. In the peripheral immune system, UK4 increased the prevalence of Treg cells and interleukin 10 levels, whereas Fr1 ameliorated the mil …
Furthermore, UK4 increased fear-dependent contextual memory, yet decreased milk gavage-induced improvements in long-term spatial lear …
35 results