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Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial.
Chevret S, Bouadma L, Dupuis C, Burdet C, Timsit JF; COVIDICUS RCT group. Chevret S, et al. Ann Intensive Care. 2023 Aug 27;13(1):75. doi: 10.1186/s13613-023-01168-z. Ann Intensive Care. 2023. PMID: 37634234 Free PMC article.
TRIAL REGISTRATION: NCT04344730, date of registration April 14, 2020 ( https://clinicaltrials.gov/ct2/show/NCT04344730?term=NCT04344730&draw=2&rank=1 ); EudraCT: 2020-001457-43 ( https://www.clinicaltrialsregister.eu/ctr-search/search?...
TRIAL REGISTRATION: NCT04344730, date of registration April 14, 2020 ( https://clinicaltrials.gov/ct2/show/NCT04344730?term=NCT043447 …
Sedation practice and discomfort during withdrawal of mechanical ventilation in critically ill patients at end-of-life: a post-hoc analysis of a multicenter study.
Robert R, Le Gouge A, Kentish-Barnes N, Adda M, Audibert J, Barbier F, Bourcier S, Bourenne J, Boyer A, Devaquet J, Grillet G, Guisset O, Hyacinthe AC, Jourdain M, Lerolle N, Lesieur O, Mercier E, Messika J, Renault A, Vinatier I, Azoulay E, Thille AW, Reignier J; group SEDARREVE. Robert R, et al. Among authors: devaquet j. Intensive Care Med. 2020 Jun;46(6):1194-1203. doi: 10.1007/s00134-020-05930-w. Epub 2020 Jan 29. Intensive Care Med. 2020. PMID: 31996960
After multivariate logistic regression, extubation (as compared terminal weaning) was the only factor associated with discomfort, whereas deep sedation and administration of vasoactive drugs were two factors independently associated with no discomfort. Long-term evaluation …
After multivariate logistic regression, extubation (as compared terminal weaning) was the only factor associated with discomfort, whereas de …
Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation.
Brosseau C, Danger R, Durand M, Durand E, Foureau A, Lacoste P, Tissot A, Roux A, Reynaud-Gaubert M, Kessler R, Mussot S, Dromer C, Brugière O, Mornex JF, Guillemain R, Claustre J, Magnan A, Brouard S; COLT and SysCLAD Consortia. Brosseau C, et al. Am J Transplant. 2019 Nov;19(11):3162-3175. doi: 10.1111/ajt.15532. Epub 2019 Aug 21. Am J Transplant. 2019. PMID: 31305014 Free article.
Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. ...CD9-expressing B cells appear as a contributor to a favorable environment …
Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell popu …
[Evolution and progress of lung transplantation: An analysis of a cohort of 600 lung transplant patients at the Hospital Foch].
Roux A, Sage E, Cerf C, Le Guen M, Picard C, Hamid AM, Parquin F, Stern M, Bonnette P; Groupe de transplantation pulmonaire de l’hôpital Foch. Roux A, et al. Rev Mal Respir. 2019 Feb;36(2):142-154. doi: 10.1016/j.rmr.2018.02.014. Epub 2019 Jan 24. Rev Mal Respir. 2019. PMID: 30686555 French.
Proliferative complications, arterial hypertension and renal function impairment are being monitored long term. CONCLUSION: The twenty-five years experience shows a consistent improvement in the results of lung transplantation which is now accepted as the only effective cu …
Proliferative complications, arterial hypertension and renal function impairment are being monitored long term. CONCLUSION: The twent …
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome.
Danger R, Royer PJ, Reboulleau D, Durand E, Loy J, Tissot A, Lacoste P, Roux A, Reynaud-Gaubert M, Gomez C, Kessler R, Mussot S, Dromer C, Brugière O, Mornex JF, Guillemain R, Dahan M, Knoop C, Botturi K, Foureau A, Pison C, Koutsokera A, Nicod LP, Brouard S, Magnan A; COLT and SysCLAD Consortia. Danger R, et al. Front Immunol. 2018 Jan 11;8:1841. doi: 10.3389/fimmu.2017.01841. eCollection 2017. Front Immunol. 2018. PMID: 29375549 Free PMC article.
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is essential to prevent the progression of dysfunction before irreversible dama …
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term surviv …
Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung.
Mouraux S, Bernasconi E, Pattaroni C, Koutsokera A, Aubert JD, Claustre J, Pison C, Royer PJ, Magnan A, Kessler R, Benden C, Soccal PM, Marsland BJ, Nicod LP; SysCLAD Consortium. Mouraux S, et al. J Allergy Clin Immunol. 2018 Feb;141(2):718-729.e7. doi: 10.1016/j.jaci.2017.06.022. Epub 2017 Jul 18. J Allergy Clin Immunol. 2018. PMID: 28729000 Free PMC article. Clinical Trial.
BACKGROUND: Homeostatic turnover of the extracellular matrix conditions the structure and function of the healthy lung. In lung transplantation, long-term management remains limited by chronic lung allograft dysfunction, an umbrella term used for a heterogeneous ent …
BACKGROUND: Homeostatic turnover of the extracellular matrix conditions the structure and function of the healthy lung. In lung transplantat …
Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome.
Pineton de Chambrun M, Gousseff M, Mauhin W, Lega JC, Lambert M, Rivière S, Dossier A, Ruivard M, Lhote F, Blaison G, Alric L, Agard C, Saadoun D, Graveleau J, Soubrier M, Lucchini-Lecomte MJ, Christides C, Bosseray A, Levesque H, Viallard JF, Tieulie N, Lovey PY, Le Moal S, Bibes B, Malizia G, Abgueguen P, Lifermann F, Ninet J, Hatron PY, Amoura Z; EurêClark Study Group. Pineton de Chambrun M, et al. Am J Med. 2017 Oct;130(10):1219.e19-1219.e27. doi: 10.1016/j.amjmed.2017.05.023. Epub 2017 Jun 9. Am J Med. 2017. PMID: 28602874
This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome. ...
This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammop …
T Cells Promote Bronchial Epithelial Cell Secretion of Matrix Metalloproteinase-9 via a C-C Chemokine Receptor Type 2 Pathway: Implications for Chronic Lung Allograft Dysfunction.
Pain M, Royer PJ, Loy J, Girardeau A, Tissot A, Lacoste P, Roux A, Reynaud-Gaubert M, Kessler R, Mussot S, Dromer C, Brugière O, Mornex JF, Guillemain R, Dahan M, Knoop C, Botturi K, Pison C, Danger R, Brouard S, Magnan A; COLT Consortium. Pain M, et al. Am J Transplant. 2017 Jun;17(6):1502-1514. doi: 10.1111/ajt.14166. Epub 2017 Jan 23. Am J Transplant. 2017. PMID: 27982503 Free article.
Chronic lung allograft dysfunction (CLAD) is the major limitation of long-term survival after lung transplantation. CLAD manifests as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). ...
Chronic lung allograft dysfunction (CLAD) is the major limitation of long-term survival after lung transplantation. CLAD manifests as …
Impact of mild hypoxemia on renal function and renal resistive index during mechanical ventilation.
Darmon M, Schortgen F, Leon R, Moutereau S, Mayaux J, Di Marco F, Devaquet J, Brun-Buisson C, Brochard L. Darmon M, et al. Among authors: devaquet j. Intensive Care Med. 2009 Jun;35(6):1031-8. doi: 10.1007/s00134-008-1372-5. Epub 2009 Feb 26. Intensive Care Med. 2009. PMID: 19242676
RATIONALE: Short-term hypoxemia affects diuresis and natriuresis in healthy individuals. ...CONCLUSION: In patients with ALI, mild hypoxemia related to short-term low FiO(2) induce increases in diuresis and in renal RI. This latter point suggests intra-renal mechani …
RATIONALE: Short-term hypoxemia affects diuresis and natriuresis in healthy individuals. ...CONCLUSION: In patients with ALI, mild hy …