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Surviving Sepsis Campaign Research Priorities 2023.
De Backer D, Deutschman CS, Hellman J, Myatra SN, Ostermann M, Prescott HC, Talmor D, Antonelli M, Pontes Azevedo LC, Bauer SR, Kissoon N, Loeches IM, Nunnally M, Tissieres P, Vieillard-Baron A, Coopersmith CM; Surviving Sepsis Campaign Research Committee. De Backer D, et al. Among authors: deutschman cs. Crit Care Med. 2024 Feb 1;52(2):268-296. doi: 10.1097/CCM.0000000000006135. Epub 2024 Jan 19. Crit Care Med. 2024. PMID: 38240508
CONCLUSIONS: Knowledge advances in multiple clinical domains have been incorporated in progressive iterations of the Surviving Sepsis Campaign guidelines, allowing for evidence-based recommendations for short- and long-term management of sepsis. However, the strength of ex …
CONCLUSIONS: Knowledge advances in multiple clinical domains have been incorporated in progressive iterations of the Surviving Sepsis Campai …
CD4 and CD8 T Cell Memory Interactions Alter Innate Immunity and Organ Injury in the CLP Sepsis Model.
Taylor MD, Fernandes TD, Kelly AP, Abraham MN, Deutschman CS. Taylor MD, et al. Among authors: deutschman cs. Front Immunol. 2020 Nov 20;11:563402. doi: 10.3389/fimmu.2020.563402. eCollection 2020. Front Immunol. 2020. PMID: 33329524 Free PMC article.
We induced isolated T cell memory by inoculating C57Bl/6 mice with an anti-CD3 activating antibody, a process we term "immune education." These mice were subjected to the cecal ligation and puncture (CLP) model of sepsis and responses were compared to those of isotype-trea …
We induced isolated T cell memory by inoculating C57Bl/6 mice with an anti-CD3 activating antibody, a process we term "immune educati …
Surviving sepsis campaign: research priorities for sepsis and septic shock.
Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. Coopersmith CM, et al. Among authors: deutschman cs. Intensive Care Med. 2018 Sep;44(9):1400-1426. doi: 10.1007/s00134-018-5175-z. Epub 2018 Jul 3. Intensive Care Med. 2018. PMID: 29971592 Free PMC article.
; (4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; (5) what are the predictors of sepsis long-term morbidity and mortality?; and (6) what information identifies organ dysfunction? ...
; (4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; (5) what are the predictors of sepsis long-term …
Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock.
Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. Coopersmith CM, et al. Among authors: deutschman cs. Crit Care Med. 2018 Aug;46(8):1334-1356. doi: 10.1097/CCM.0000000000003225. Crit Care Med. 2018. PMID: 29957716
; 4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; 5) what are the predictors of sepsis long-term morbidity and mortality?; and 6) what information identifies organ dysfunction? ...
; 4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; 5) what are the predictors of sepsis long-term …
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. Singer M, et al. Among authors: deutschman cs. JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. JAMA. 2016. PMID: 26903338 Free PMC article.
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in reported incidence and observed mortality. The task force concluded the term severe sepsis was redundant. RECOMMENDATIONS: Sepsis should …
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in rep …
MITOCHONDRIAL FUNCTION IN SEPSIS.
Arulkumaran N, Deutschman CS, Pinsky MR, Zuckerbraun B, Schumacker PT, Gomez H, Gomez A, Murray P, Kellum JA; ADQI XIV Workgroup. Arulkumaran N, et al. Among authors: deutschman cs. Shock. 2016 Mar;45(3):271-81. doi: 10.1097/SHK.0000000000000463. Shock. 2016. PMID: 26871665 Free PMC article. Review.
Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long-term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for in …
Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only …
Altered hepatic gene expression in fecal peritonitis: changes in transcription of gluconeogenic, beta-oxidative, and ureagenic genes.
Andrejko KM, Deutschman CS. Andrejko KM, et al. Among authors: deutschman cs. Shock. 1997 Mar;7(3):164-9. Shock. 1997. PMID: 9068080
These decreases were persistent, with only partial recovery of either mRNA levels or transcription rates at 72 h. These findings could explain in part the long-term alterations in gluconeogenesis, beta-oxidation, and ureagenesis observed in sepsis. ...
These decreases were persistent, with only partial recovery of either mRNA levels or transcription rates at 72 h. These findings could expla …