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Long-Term Improvement in Cardiorespiratory Fitness Ameliorates Insulin Sensitivity beyond Changes in Visceral/Ectopic Fat among Men with Visceral Obesity.
Murphy-Després A, Chartrand DJ, Lemieux I, Tremblay A, Bergeron J, Poirier P, Alméras N, Després JP. Murphy-Després A, et al. Among authors: despres jp. Nutrients. 2024 May 1;16(9):1377. doi: 10.3390/nu16091377. Nutrients. 2024. PMID: 38732623 Free PMC article.
We tested the hypothesis that variations in cardiorespiratory fitness (CRF) and LAM could explain the long-term improvement in IR. A health (n = 88; mean age 49.0 8.2 years) and fitness (n = 72) evaluation was performed at 0, 1, and 3 years. ...These results support the im …
We tested the hypothesis that variations in cardiorespiratory fitness (CRF) and LAM could explain the long-term improvement in IR. A …
Adiposity, type 2 diabetes and atherosclerotic cardiovascular disease risk: Use and abuse of the body mass index.
Arsenault BJ, Carpentier AC, Poirier P, Després JP. Arsenault BJ, et al. Among authors: despres jp. Atherosclerosis. 2024 Apr 14:117546. doi: 10.1016/j.atherosclerosis.2024.117546. Online ahead of print. Atherosclerosis. 2024. PMID: 38692978 Free article. Review.
Increasing evidence also suggests that, as opposed to weight inclusive, lifestyle-based approaches, weight-centric approaches advising people to simply eat less and move more are not sustainable for most people for long-term weight loss and maintenance. It is time to recog …
Increasing evidence also suggests that, as opposed to weight inclusive, lifestyle-based approaches, weight-centric approaches advising peopl …
Effects of CB1R inverse agonist, INV-202, in patients with features of metabolic syndrome. A randomized, placebo-controlled, double-blind phase 1b study.
Crater GD, Lalonde K, Ravenelle F, Harvey M, Després JP. Crater GD, et al. Among authors: despres jp. Diabetes Obes Metab. 2024 Feb;26(2):642-649. doi: 10.1111/dom.15353. Epub 2023 Nov 8. Diabetes Obes Metab. 2024. PMID: 37941317 Clinical Trial.
CONCLUSIONS: INV-202 was well tolerated, producing a signal for rapid weight loss with improvements in other metabolic syndrome markers in this population. These findings support further exploration and long-term assessment of cardiometabolic effects....
CONCLUSIONS: INV-202 was well tolerated, producing a signal for rapid weight loss with improvements in other metabolic syndrome markers in t …
From syndrome X to cardiometabolic risk: clinical and public health implications.
Després JP. Després JP. Proc Nutr Soc. 2020 Feb;79(1):4-10. doi: 10.1017/S0029665119001010. Epub 2019 Jul 18. Proc Nutr Soc. 2020. PMID: 31317841
Because there was a syndrome X documented in cardiology, the term evolved to insulin resistance syndrome. As Reaven could also find insulin-resistant individuals in non-obese subjects, he did not include obesity as a feature of syndrome X. ...
Because there was a syndrome X documented in cardiology, the term evolved to insulin resistance syndrome. As Reaven could also find i …
Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association.
Johnson RK, Lichtenstein AH, Anderson CAM, Carson JA, Després JP, Hu FB, Kris-Etherton PM, Otten JJ, Towfighi A, Wylie-Rosett J; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Quality of Care and Outcomes Research; and Stroke Council. Johnson RK, et al. Among authors: despres jp. Circulation. 2018 Aug 28;138(9):e126-e140. doi: 10.1161/CIR.0000000000000569. Circulation. 2018. PMID: 30354445 Free article. Review.
Among all foods and beverages containing LCSs, beverages represent the largest proportion of LCS consumption worldwide. The term LCS includes the 6 high-intensity sweeteners currently approved by the US Food and Drug Administration and 2 additional high-intensity sweetener …
Among all foods and beverages containing LCSs, beverages represent the largest proportion of LCS consumption worldwide. The term LCS …
Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort.
Chau K, Girerd N, Magnusson M, Lamiral Z, Bozec E, Merckle L, Leosdottir M, Bachus E, Frikha Z, Ferreira JP, Després JP, Rossignol P, Boivin JM, Zannad F. Chau K, et al. Among authors: despres jp. Clin Res Cardiol. 2018 Oct;107(10):887-896. doi: 10.1007/s00392-018-1259-6. Epub 2018 Apr 21. Clin Res Cardiol. 2018. PMID: 29680861
CONCLUSIONS: Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help reduce the incidence of DD....
CONCLUSIONS: Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help red …
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.
Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, Paige E, Paul DS, Sweeting M, Burgess S, Bell S, Astle W, Stevens D, Koulman A, Selmer RM, Verschuren WMM, Sato S, Njølstad I, Woodward M, Salomaa V, Nordestgaard BG, Yeap BB, Fletcher A, Melander O, Kuller LH, Balkau B, Marmot M, Koenig W, Casiglia E, Cooper C, Arndt V, Franco OH, Wennberg P, Gallacher J, de la Cámara AG, Völzke H, Dahm CC, Dale CE, Bergmann MM, Crespo CJ, van der Schouw YT, Kaaks R, Simons LA, Lagiou P, Schoufour JD, Boer JMA, Key TJ, Rodriguez B, Moreno-Iribas C, Davidson KW, Taylor JO, Sacerdote C, Wallace RB, Quiros JR, Tumino R, Blazer DG 2nd, Linneberg A, Daimon M, Panico S, Howard B, Skeie G, Strandberg T, Weiderpass E, Nietert PJ, Psaty BM, Kromhout D, Salamanca-Fernandez E, Kiechl S, Krumholz HM, Grioni S, Palli D, Huerta JM, Price J, Sundström J, Arriola L, Arima H, Travis RC, Panagiotakos DB, Karakatsani A, Trichopoulou A, Kühn T, Grobbee DE, Barrett-Connor E, van Schoor N, Boeing H, Overvad K, Kauhanen J, Wareham N, Langenberg C, Forouhi N, Wennberg M, Després JP, Cushman M, Cooper JA, Rodriguez CJ, Sakurai M, Shaw JE, Knuiman M, Voortman T, Meisinger C, Tjønneland A, Brenner… See abstract for full author list ➔ Wood AM, et al. Among authors: despres jp. Lancet. 2018 Apr 14;391(10129):1513-1523. doi: 10.1016/S0140-6736(18)30134-X. Lancet. 2018. PMID: 29676281 Free PMC article.
We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some …
We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtype …
Cardiometabolic risk improvement in response to a 3-yr lifestyle modification program in men: contribution of improved cardiorespiratory fitness vs. weight loss.
Borel AL, Nazare JA, Baillot A, Alméras N, Tremblay A, Bergeron J, Poirier P, Després JP. Borel AL, et al. Among authors: despres jp. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E273-E281. doi: 10.1152/ajpendo.00278.2016. Epub 2016 Dec 27. Am J Physiol Endocrinol Metab. 2017. PMID: 28028035 Free article.

Three-year changes in fat mass and CRF were independently associated with changes in visceral fat (adjusted r(2) = 0.40, P < 0.001), whereas only changes in CRF were associated with changes in estimated liver fat (adjusted r(2) = 0.18, P < 0.001). A long-term (3 yr)

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Three-year changes in fat mass and CRF were independently associated with changes in visceral fat (adjusted r(2) = 0.40, P < 0.001), wher

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The Underestimated Belly Factor: Waist Circumference Is Linked to Significant Morbidity Following Isolated Coronary Artery Bypass Grafting.
Chassé M, Mathieu P, Voisine P, Després JP, Pibarot P, Baillot R, Lellouche F, Poirier P. Chassé M, et al. Among authors: despres jp. Can J Cardiol. 2016 Mar;32(3):327-35. doi: 10.1016/j.cjca.2015.06.031. Epub 2015 Jul 7. Can J Cardiol. 2016. PMID: 26481079
METHODS: We analyzed the associations of WC and BMI with short-term postoperative outcomes in a cohort of 7446 patients who underwent isolated CABG. ...This association was observed for men and women, across all overweight and obesity categories. Neither WC nor BMI was ass …
METHODS: We analyzed the associations of WC and BMI with short-term postoperative outcomes in a cohort of 7446 patients who underwent …
75 results