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Reactive Astrocytes: Critical Players in the Development of Chronic Pain.
Tang J, Bair M, Descalzi G. Tang J, et al. Among authors: descalzi g. Front Psychiatry. 2021 May 28;12:682056. doi: 10.3389/fpsyt.2021.682056. eCollection 2021. Front Psychiatry. 2021. PMID: 34122194 Free PMC article. Review.
Chronic pain is associated with long term plasticity of nociceptive pathways in the central nervous system. ...
Chronic pain is associated with long term plasticity of nociceptive pathways in the central nervous system. ...
Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons.
Descalzi G, Gao V, Steinman MQ, Suzuki A, Alberini CM. Descalzi G, et al. Commun Biol. 2019 Jul 2;2:247. doi: 10.1038/s42003-019-0495-2. eCollection 2019. Commun Biol. 2019. PMID: 31286064 Free PMC article.
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. ...Thus, astrocytic lactate acts as an energy substrate to fuel learning-induced de novo neuronal translation crit …
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lact …
Astrocyte glycogen and lactate: New insights into learning and memory mechanisms.
Alberini CM, Cruz E, Descalzi G, Bessières B, Gao V. Alberini CM, et al. Among authors: descalzi g. Glia. 2018 Jun;66(6):1244-1262. doi: 10.1002/glia.23250. Epub 2017 Oct 27. Glia. 2018. PMID: 29076603 Free PMC article. Review.
In this review, we summarize and discuss recent findings on the critical role of astrocytes as providers of energy for the long-lasting neuronal changes that are necessary for long-term memory formation. We focus on three main findings: first, the role of glucose metabolis …
In this review, we summarize and discuss recent findings on the critical role of astrocytes as providers of energy for the long-lasting neur …
Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression.
Descalzi G, Mitsi V, Purushothaman I, Gaspari S, Avrampou K, Loh YE, Shen L, Zachariou V. Descalzi G, et al. Sci Signal. 2017 Mar 21;10(471):eaaj1549. doi: 10.1126/scisignal.aaj1549. Sci Signal. 2017. PMID: 28325815 Free PMC article.
Our study provides a resource of the changes in gene expression induced by long-term neuropathic pain in three distinct brain regions and reveals molecular connections between pain and chronic stress....
Our study provides a resource of the changes in gene expression induced by long-term neuropathic pain in three distinct brain regions …
Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.
Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M. Koga K, et al. Among authors: descalzi g. Neuron. 2015 Jan 21;85(2):377-89. doi: 10.1016/j.neuron.2014.12.021. Epub 2014 Dec 31. Neuron. 2015. PMID: 25556835 Free PMC article.
Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors a …
Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms o …
Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury.
Chen T, Koga K, Descalzi G, Qiu S, Wang J, Zhang LS, Zhang ZJ, He XB, Qin X, Xu FQ, Hu J, Wei F, Huganir RL, Li YQ, Zhuo M. Chen T, et al. Among authors: descalzi g. Mol Pain. 2014 Jun 3;10:33. doi: 10.1186/1744-8069-10-33. Mol Pain. 2014. PMID: 24890933 Free PMC article.
Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. ...Our findings provide strong evidence that peripheral nerve injury induce long-term enhancement of cortical-spinal projecting cells in the ACC. ...
Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. ...Our findings …
Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome.
Chen T, Lu JS, Song Q, Liu MG, Koga K, Descalzi G, Li YQ, Zhuo M. Chen T, et al. Among authors: descalzi g. Neuropsychopharmacology. 2014 Jul;39(8):1955-67. doi: 10.1038/npp.2014.44. Epub 2014 Feb 20. Neuropsychopharmacology. 2014. PMID: 24553731 Free PMC article.
Fragile X syndrome, caused by the mutation of the Fmr1 gene, is characterized by deficits of attention and learning ability. In the hippocampus of Fmr1 knockout mice (KO), long-term depression is enhanced whereas long-term potentiation (LTP) including late-phase LTP …
Fragile X syndrome, caused by the mutation of the Fmr1 gene, is characterized by deficits of attention and learning ability. In the hippocam …
An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain.
Qiu S, Chen T, Koga K, Guo YY, Xu H, Song Q, Wang JJ, Descalzi G, Kaang BK, Luo JH, Zhuo M, Zhao MG. Qiu S, et al. Among authors: descalzi g. Sci Signal. 2013 May 14;6(275):ra34. doi: 10.1126/scisignal.2003778. Sci Signal. 2013. PMID: 23674822
We found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed changes in synaptic plasticity, which were associated with a long-term increase in the amount of synaptic N-methyl-d-aspartate receptors …
We found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed chan …
Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning.
Descalzi G, Li XY, Chen T, Mercaldo V, Koga K, Zhuo M. Descalzi G, et al. Mol Brain. 2012 Feb 3;5:6. doi: 10.1186/1756-6606-5-6. Mol Brain. 2012. PMID: 22304729 Free PMC article.
Although the cortex has been extensively studied in long-term memory storage, less emphasis has been placed on immediate cortical contributions to fear memory formation. ...
Although the cortex has been extensively studied in long-term memory storage, less emphasis has been placed on immediate cortical con …
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