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Targeted pulmonary delivery of inducers of host macrophage autophagy as a potential host-directed chemotherapy of tuberculosis.
Adv Drug Deliv Rev. 2016 Jul 1;102:10-20. doi: 10.1016/j.addr.2016.01.016. Epub 2016 Jan 29.
Adv Drug Deliv Rev. 2016.
PMID: 26829287
Free PMC article.
Review.
The choice of drugs, drug release kinetics and intracellular residence times, non-target cell exposure and feasibility of use by patients is discussed. We term here this (still experimental) approach, of compartment-targeting, autophagy-based, host-directed therapy as "Tra …
The choice of drugs, drug release kinetics and intracellular residence times, non-target cell exposure and feasibility of use by patients is …
Autophagy as an immune defense mechanism.
Deretic V.
Deretic V.
Curr Opin Immunol. 2006 Aug;18(4):375-82. doi: 10.1016/j.coi.2006.05.019. Epub 2006 Jun 19.
Curr Opin Immunol. 2006.
PMID: 16782319
Review.
A further link has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase lrgm1 (LRG-47), which has a protective role against Mycobacterium tuberculosis. We propose the term immunophagy for these defense processes....
A further link has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase lrgm1 (LRG-47), whi …
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Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade.
Vergne I, Chua J, Deretic V.
Vergne I, et al. Among authors: deretic v.
J Exp Med. 2003 Aug 18;198(4):653-9. doi: 10.1084/jem.20030527.
J Exp Med. 2003.
PMID: 12925680
Free PMC article.
The interference of the trafficking toxin LAM with the calmodulin-dependent production of PI3P described here ensures long-term M. tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages....
The interference of the trafficking toxin LAM with the calmodulin-dependent production of PI3P described here ensures long-term M. tu …
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