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Targeted pulmonary delivery of inducers of host macrophage autophagy as a potential host-directed chemotherapy of tuberculosis.
Gupta A, Misra A, Deretic V. Gupta A, et al. Among authors: deretic v. Adv Drug Deliv Rev. 2016 Jul 1;102:10-20. doi: 10.1016/j.addr.2016.01.016. Epub 2016 Jan 29. Adv Drug Deliv Rev. 2016. PMID: 26829287 Free PMC article. Review.
The choice of drugs, drug release kinetics and intracellular residence times, non-target cell exposure and feasibility of use by patients is discussed. We term here this (still experimental) approach, of compartment-targeting, autophagy-based, host-directed therapy as "Tra …
The choice of drugs, drug release kinetics and intracellular residence times, non-target cell exposure and feasibility of use by patients is …
Autophagy as an immune defense mechanism.
Deretic V. Deretic V. Curr Opin Immunol. 2006 Aug;18(4):375-82. doi: 10.1016/j.coi.2006.05.019. Epub 2006 Jun 19. Curr Opin Immunol. 2006. PMID: 16782319 Review.
A further link has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase lrgm1 (LRG-47), which has a protective role against Mycobacterium tuberculosis. We propose the term immunophagy for these defense processes....
A further link has emerged between autophagy and defense against intracellular pathogens via the immunity-related GTPase lrgm1 (LRG-47), whi …
Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade.
Vergne I, Chua J, Deretic V. Vergne I, et al. Among authors: deretic v. J Exp Med. 2003 Aug 18;198(4):653-9. doi: 10.1084/jem.20030527. J Exp Med. 2003. PMID: 12925680 Free PMC article.
The interference of the trafficking toxin LAM with the calmodulin-dependent production of PI3P described here ensures long-term M. tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages....
The interference of the trafficking toxin LAM with the calmodulin-dependent production of PI3P described here ensures long-term M. tu …