Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Filters applied: . Clear all
Page 1
Environmental pharmacology-Dosing the environment: IUPHAR review 36.
Connolly CN, Alexander SPH, Davies JA, Spedding M. Connolly CN, et al. Among authors: davies ja. Br J Pharmacol. 2022 Dec;179(23):5172-5179. doi: 10.1111/bph.15933. Epub 2022 Aug 16. Br J Pharmacol. 2022. PMID: 35975296 Free PMC article.
These principles include relating the steady state dose of an agent to its beneficial effects (e.g. pest control), while minimising harmful impacts (e.g. off-target bioactivity in beneficial insects). We propose the term 'environmental therapeutic window', analogous to tha …
These principles include relating the steady state dose of an agent to its beneficial effects (e.g. pest control), while minimising harmful …
Automation in the Life Science Research Laboratory.
Holland I, Davies JA. Holland I, et al. Among authors: davies ja. Front Bioeng Biotechnol. 2020 Nov 13;8:571777. doi: 10.3389/fbioe.2020.571777. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 33282848 Free PMC article. Review.
Causes of this 'automation gap' are unique to academic research, with rigid short-term funding structures, high levels of protocol variability and a benevolent culture of investment in people over equipment. ...
Causes of this 'automation gap' are unique to academic research, with rigid short-term funding structures, high levels of protocol va …
Regenerative medicine therapies: lessons from the kidney.
Davies JA, Murray P, Wilm B. Davies JA, et al. Curr Opin Physiol. 2020 Apr;14:41-47. doi: 10.1016/j.cophys.2019.12.008. Curr Opin Physiol. 2020. PMID: 32467861 Free PMC article. Review.
Most current work aims to stimulate endogenous regeneration or to grow new organs but much remains to be done; misplaced hype about short-term prospects of regenerative medicine helps neither researchers nor patients....
Most current work aims to stimulate endogenous regeneration or to grow new organs but much remains to be done; misplaced hype about short- …
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29.
Alexander SPH, Armstrong JF, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding M. Alexander SPH, et al. Among authors: davies ja. Br J Pharmacol. 2020 Nov;177(21):4942-4966. doi: 10.1111/bph.15094. Epub 2020 Jul 19. Br J Pharmacol. 2020. PMID: 32358833 Free PMC article. Review.
We assess the scope for targeting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed, an agenda for drug repurposing, which should allow rapid translation to clinical trials. A simultaneous, multi-pronged approach us …
We assess the scope for targeting key host and viral targets in the mid-term, by first screening these targets against drugs already …
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Alexander SPH, et al. Among authors: davies ja. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748. Br J Pharmacol. 2019. PMID: 31710717 Free PMC article. Review.
Impact of two centuries of intensive agriculture on soil carbon, nitrogen and phosphorus cycling in the UK.
Muhammed SE, Coleman K, Wu L, Bell VA, Davies JAC, Quinton JN, Carnell EJ, Tomlinson SJ, Dore AJ, Dragosits U, Naden PS, Glendining MJ, Tipping E, Whitmore AP. Muhammed SE, et al. Among authors: davies jac. Sci Total Environ. 2018 Sep 1;634:1486-1504. doi: 10.1016/j.scitotenv.2018.03.378. Epub 2018 Apr 18. Sci Total Environ. 2018. PMID: 29710647 Free PMC article.
The Roth-CNP model was developed as part of an Integrated Model (IM) to simulate C, N and P cycling for the whole of UK, by loosely coupling terrestrial, hydrological and hydro-chemical models. The model was calibrated and tested using long term experiment (LTE) data from …
The Roth-CNP model was developed as part of an Integrated Model (IM) to simulate C, N and P cycling for the whole of UK, by loosely coupling …
Long-term increases in soil carbon due to ecosystem fertilization by atmospheric nitrogen deposition demonstrated by regional-scale modelling and observations.
Tipping E, Davies JAC, Henrys PA, Kirk GJD, Lilly A, Dragosits U, Carnell EJ, Dore AJ, Sutton MA, Tomlinson SJ. Tipping E, et al. Among authors: davies jac. Sci Rep. 2017 May 15;7(1):1890. doi: 10.1038/s41598-017-02002-w. Sci Rep. 2017. PMID: 28507306 Free PMC article.
The results are the first to validate model predictions of N(dep) effects against observations of SOC at a regional field scale. They demonstrate the importance of long-term macronutrient interactions and the transitory nature of soil responses in the terrestrial C cycle.. …
The results are the first to validate model predictions of N(dep) effects against observations of SOC at a regional field scale. They demons …
150years of macronutrient change in unfertilized UK ecosystems: Observations vs simulations.
Davies JAC, Tipping E, Whitmore AP. Davies JAC, et al. Sci Total Environ. 2016 Dec 1;572:1485-1495. doi: 10.1016/j.scitotenv.2016.03.055. Epub 2016 Mar 21. Sci Total Environ. 2016. PMID: 27012185 Free article.
Understanding changes in plant-soil C, N and P using data alone is difficult due to the linkages between carbon, nitrogen and phosphorus cycles (C, N and P), and multiple changing long-term drivers (e.g. climate, land-use, and atmospheric N deposition). ...Here, a simulati …
Understanding changes in plant-soil C, N and P using data alone is difficult due to the linkages between carbon, nitrogen and phosphorus cyc …
In vivo maturation of functional renal organoids formed from embryonic cell suspensions.
Xinaris C, Benedetti V, Rizzo P, Abbate M, Corna D, Azzollini N, Conti S, Unbekandt M, Davies JA, Morigi M, Benigni A, Remuzzi G. Xinaris C, et al. Among authors: davies ja. J Am Soc Nephrol. 2012 Nov;23(11):1857-68. doi: 10.1681/ASN.2012050505. Epub 2012 Oct 18. J Am Soc Nephrol. 2012. PMID: 23085631 Free PMC article.
The ability to generate vascularized nephrons from single-cell suspensions marks a significant step to the long-term goal of replacing renal function by a tissue-engineered kidney....
The ability to generate vascularized nephrons from single-cell suspensions marks a significant step to the long-term goal of replacin …
26 results