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The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation.
Smith KJ, Minns D, McHugh BJ, Holloway RK, O'Connor R, Williams A, Melrose L, McPherson R, Miron VE, Davidson DJ, Gwyer Findlay E. Smith KJ, et al. Among authors: davidson dj. PLoS Biol. 2022 Aug 26;20(8):e3001554. doi: 10.1371/journal.pbio.3001554. eCollection 2022 Aug. PLoS Biol. 2022. PMID: 36026478 Free PMC article.
Although evidence is mounting that the antimicrobial peptide cathelicidin profoundly affects early T cell differentiation, no studies have looked at its role in longer-term T cell responses. Now, we report that cathelicidin drives severe EAE disease. ...
Although evidence is mounting that the antimicrobial peptide cathelicidin profoundly affects early T cell differentiation, no studies have l …
Targeting cystic fibrosis inflammation in the age of CFTR modulators: focus on macrophages.
Gillan JL, Davidson DJ, Gray RD. Gillan JL, et al. Among authors: davidson dj. Eur Respir J. 2021 Jun 4;57(6):2003502. doi: 10.1183/13993003.03502-2020. Print 2021 Jun. Eur Respir J. 2021. PMID: 33303535 Free article. Review.
Despite the exciting success of these drugs, their impact on airway inflammation, and its long-term consequences, remains undetermined. In addition, studies querying the absolute requirement for infection as a driver of CF inflammation have challenged the traditional conse …
Despite the exciting success of these drugs, their impact on airway inflammation, and its long-term consequences, remains undetermine …
Inflammation-mediated generation and inflammatory potential of human placental cell-free fetal DNA.
van Boeckel SR, Macpherson H, Norman JE, Davidson DJ, Stock SJ. van Boeckel SR, et al. Among authors: davidson dj. Placenta. 2020 Apr;93:49-55. doi: 10.1016/j.placenta.2020.02.016. Epub 2020 Feb 24. Placenta. 2020. PMID: 32250739 Free PMC article.
However, whether cff-DNA is directly pro-inflammatory in pregnant women and what regulates cff-DNA levels in pregnancy are unknown. METHODS: Using a human term placental explant model, we examined whether induction of placental inflammation can promote cff-DNA release, and …
However, whether cff-DNA is directly pro-inflammatory in pregnant women and what regulates cff-DNA levels in pregnancy are unknown. METHODS: …
Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland.
Boardman JP, Hall J, Thrippleton MJ, Reynolds RM, Bogaert D, Davidson DJ, Schwarze J, Drake AJ, Chandran S, Bastin ME, Fletcher-Watson S. Boardman JP, et al. Among authors: davidson dj. BMJ Open. 2020 Mar 4;10(3):e035854. doi: 10.1136/bmjopen-2019-035854. BMJ Open. 2020. PMID: 32139495 Free PMC article.
We aimed to investigate neuroanatomic variation and adverse outcomes associated with preterm birth by studying a cohort of preterm infants and controls born at term using brain MRI linked to biosamples and clinical, environmental and neuropsychological data. METHODS …
We aimed to investigate neuroanatomic variation and adverse outcomes associated with preterm birth by studying a cohort of preterm in …
Cathelicidins and the Onset of Labour.
Boeckel SRV, Hrabalkova L, Baker TL, MacPherson H, Frew L, Boyle AK, McHugh BJ, Wilson K, Norman JE, Dorin JR, Davidson DJ, Stock SJ. Boeckel SRV, et al. Among authors: davidson dj. Sci Rep. 2019 May 14;9(1):7356. doi: 10.1038/s41598-019-43766-7. Sci Rep. 2019. PMID: 31089176 Free PMC article.
Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence peptide, is induc …
Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection …
Cell-free fetal DNA and spontaneous preterm birth.
van Boeckel SR, Davidson DJ, Norman JE, Stock SJ. van Boeckel SR, et al. Among authors: davidson dj. Reproduction. 2018 Feb;155(3):R137-R145. doi: 10.1530/REP-17-0619. Epub 2017 Dec 21. Reproduction. 2018. PMID: 29269517 Free PMC article. Review.
Inflammation is known to play a key role in preterm and term parturition. Cell-free fetal DNA (cff-DNA) is present in the maternal circulation and increases with gestational age and some pregnancy complications (e.g. preterm birth, preeclampsia). ...Clinical studies …
Inflammation is known to play a key role in preterm and term parturition. Cell-free fetal DNA (cff-DNA) is present in the maternal ci …
Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial.
Mandal P, Chalmers JD, Graham C, Harley C, Sidhu MK, Doherty C, Govan JW, Sethi T, Davidson DJ, Rossi AG, Hill AT. Mandal P, et al. Among authors: davidson dj. Lancet Respir Med. 2014 Jun;2(6):455-63. doi: 10.1016/S2213-2600(14)70050-5. Epub 2014 Mar 24. Lancet Respir Med. 2014. PMID: 24717640 Free article. Clinical Trial.
INTERPRETATION: 6 months of atorvastatin improved cough on a quality-of-life scale in patients with bronchiectasis. Multicentre studies are now needed to assess whether long-term statin treatment can reduce exacerbations. FUNDING: Chief Scientist's Office....
INTERPRETATION: 6 months of atorvastatin improved cough on a quality-of-life scale in patients with bronchiectasis. Multicentre studies are …
Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines.
Hink WF, Thomsen DR, Davidson DJ, Meyer AL, Castellino FJ. Hink WF, et al. Among authors: davidson dj. Biotechnol Prog. 1991 Jan-Feb;7(1):9-14. doi: 10.1021/bp00007a002. Biotechnol Prog. 1991. PMID: 1367489
The objectives were to compare amounts of recombinant proteins expressed in the cell lines, compare yields from clones and parent lines, investigate the effects of long-term culture in serum-free medium on production, and determine if some lines yield gp50T with different …
The objectives were to compare amounts of recombinant proteins expressed in the cell lines, compare yields from clones and parent lines, inv …