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Page 1
Purification of a candidate gonadotropin surge inhibiting factor from porcine follicular fluid.
Danforth DR, Cheng CY. Danforth DR, et al. Endocrinology. 1995 Apr;136(4):1658-65. doi: 10.1210/endo.136.4.7895676. Endocrinology. 1995. PMID: 7895676
We present now the purification of GnSIF to homogeneity and determination of the partial NH2-terminal amino acid sequence. The bioassay for GnSIF used rat pituitary cells in short-term culture that were incubated with test fractions for 48 h, washed, and then incubated wit …
We present now the purification of GnSIF to homogeneity and determination of the partial NH2-terminal amino acid sequence. The bioassay for …
In vivo effects of a potent GnRH antagonist ORG 30850: physiologic evidence that down-regulation of GnRH receptors does not occur.
Gordon K, Scott RT, Williams RF, Danforth DR, Loozen HJ, Kloosterboer HJ, Hodgen GD. Gordon K, et al. Among authors: danforth dr. J Soc Gynecol Investig. 1994 Oct-Dec;1(4):290-6. doi: 10.1177/107155769400100408. J Soc Gynecol Investig. 1994. PMID: 9419786
METHODS: This was a prospective experimental non-human primate study performed at the research laboratories of The Jones Institute for Reproductive Medicine. Seventeen long-term ovariectomized cynomolgus monkeys were studied. INTERVENTIONS: The GnRH antagonist ORG 30850 wa …
METHODS: This was a prospective experimental non-human primate study performed at the research laboratories of The Jones Institute for Repro …
The identification of gonadotrophin surge inhibiting factor and its role in the regulation of pituitary gonadotrophin secretion.
Danforth DR, Cheng CY. Danforth DR, et al. Hum Reprod. 1993 Nov;8 Suppl 2:117-22. doi: 10.1093/humrep/8.suppl_2.117. Hum Reprod. 1993. PMID: 8276944
Utilizing a rat pituitary cell bioassay, we have monitored GnSIF activity during purification from porcine follicular fluid (PFF). Rat pituitary cells in short-term culture were incubated with GnSIF for 48 h, washed and then exposed to gonadotrophin releasing hormone (GnRH …
Utilizing a rat pituitary cell bioassay, we have monitored GnSIF activity during purification from porcine follicular fluid (PFF). Rat pitui …
Antide bioavailability: single dose administration for suppression of testosterone and inhibin in male monkeys.
Edelstein MC, Gordon K, Williams RF, Danforth DR, Winters SJ, Hodgen GD. Edelstein MC, et al. Among authors: danforth dr. Contraception. 1992 Feb;45(2):155-66. doi: 10.1016/0010-7824(92)90049-y. Contraception. 1992. PMID: 1559337
Fifteen primates were randomized to three groups receiving: propylene glycol and water vehicle, 3 mg/kg Antide, and 10 mg/kg of Antide. Antide at the 10 mg/kg dose caused long-term suppression of T ranging from 24-56 days. At the 3 mg/kg dose, suppression of T was of short …
Fifteen primates were randomized to three groups receiving: propylene glycol and water vehicle, 3 mg/kg Antide, and 10 mg/kg of Antide. Anti …
Antide-induced suppression of pituitary gonadotropin and ovarian steroid secretion in cynomolgus monkeys: premature luteolysis and prolonged inhibition of folliculogenesis following single treatment.
Gordon K, Williams RF, Danforth DR, Hodgen GD. Gordon K, et al. Among authors: danforth dr. Biol Reprod. 1991 Apr;44(4):701-6. doi: 10.1095/biolreprod44.4.701. Biol Reprod. 1991. PMID: 2043741
Administration of high-dose Antide to ovariectomized monkeys results in rapid, prolonged, and reversible inhibition of gonadotropin secretion. The present study examined whether similar long-term control would be manifested in the menstrual cycle of intact primates. ...
Administration of high-dose Antide to ovariectomized monkeys results in rapid, prolonged, and reversible inhibition of gonadotropin secretio …
Inhibition of pituitary gonadotropin secretion by the gonadotropin-releasing hormone antagonist antide. II. Development of an in vitro bioassay for characterization of pharmacokinetics and pharmacodynamics of antide in circulation.
Danforth DR, Williams RF, Gordon K, Leal JA, Hodgen GD. Danforth DR, et al. Endocrinology. 1991 Apr;128(4):2041-4. doi: 10.1210/endo-128-4-2041. Endocrinology. 1991. PMID: 1900785
Media were removed, and cells were washed twice and then incubated with GnRH (1 x 10(-8) M) plus antide standards or serum samples for 4 h. Before antide injection into long term ovariectomized monkeys, peripheral GnRH antagonist levels were undetectable. ...
Media were removed, and cells were washed twice and then incubated with GnRH (1 x 10(-8) M) plus antide standards or serum samples for 4 h. …
Inhibition of pituitary gonadotropin secretion by the gonadotropin-releasing hormone antagonist antide. I. In vitro studies on mechanism of action.
Danforth DR, Williams RF, Gordon K, Hodgen GD. Danforth DR, et al. Endocrinology. 1991 Apr;128(4):2036-40. doi: 10.1210/endo-128-4-2036. Endocrinology. 1991. PMID: 1900784
Moreover, antide has no apparent noxious or toxic effect on pituitary cells in culture; the actions of antide are immediately reversible upon removal of antide from pituitary gonadotropes. We conclude that the long term inhibition of gonadotropin secretion by antide in viv …
Moreover, antide has no apparent noxious or toxic effect on pituitary cells in culture; the actions of antide are immediately reversible upo …
Single dose long-term suppression of testosterone secretion by a gonadotropin-releasing hormone antagonist (Antide) in male monkeys.
Edelstein MC, Gordon K, Williams RF, Danforth DR, Hodgen GD. Edelstein MC, et al. Among authors: danforth dr. Contraception. 1990 Aug;42(2):209-14. doi: 10.1016/0010-7824(90)90104-4. Contraception. 1990. PMID: 2085971
This study was designed to find the minimal single dose of Antide (Nal-Lys GnRH antagonist) that would provide long-term inhibition of serum testosterone levels in adult male monkeys. ...
This study was designed to find the minimal single dose of Antide (Nal-Lys GnRH antagonist) that would provide long-term inhibition o …
Extended presence of antide (Nal-Lys GnRH antagonist) in circulation: prolonged duration of gonadotropin inhibition may derive from antide binding to serum proteins.
Danforth DR, Gordon K, Leal JA, Williams RF, Hodgen GD. Danforth DR, et al. J Clin Endocrinol Metab. 1990 Feb;70(2):554-6. doi: 10.1210/jcem-70-2-554. J Clin Endocrinol Metab. 1990. PMID: 2298867
Here, we report development of a radioreceptor assay to measure circulating Antide levels to determine the mechanism(s) of its long duration of action. Five long-term OVX monkeys were injected with Antide (3.0 mg/kg). Blood samples were collected daily for 30 days, and the …
Here, we report development of a radioreceptor assay to measure circulating Antide levels to determine the mechanism(s) of its long duration …
Probing studies on multiple dose effects of antide (Nal-Lys) GnRH antagonist in ovariectomized monkeys.
Leal JA, Gordon K, Williams RF, Danforth DR, Roh SI, Hodgen GD. Leal JA, et al. Among authors: danforth dr. Contraception. 1989 Nov;40(5):623-33. doi: 10.1016/0010-7824(89)90134-0. Contraception. 1989. PMID: 2515029
Thereafter, the state of FSH/LH inhibition was resumed chronically. Thus, treatment with Antide produced profound long-term inhibition of tonic gonadotropin levels, yet hyper-responsiveness to exogenous GnRH administration was maintained throughout....
Thereafter, the state of FSH/LH inhibition was resumed chronically. Thus, treatment with Antide produced profound long-term inhibitio …
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