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Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.
Toxicol Sci. 2000 Jan;53(1):33-9. doi: 10.1093/toxsci/53.1.33.
Toxicol Sci. 2000.
PMID: 10653518
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these …
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a f …
Effects of long-term oral administration of DDT on nonhuman primates.
Takayama S, Sieber SM, Dalgard DW, Thorgeirsson UP, Adamson RH.
Takayama S, et al. Among authors: dalgard dw.
J Cancer Res Clin Oncol. 1999;125(3-4):219-25. doi: 10.1007/s004320050266.
J Cancer Res Clin Oncol. 1999.
PMID: 10235477
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-term effects of DDT on 24 cynomolgus and rhesus monkeys. DDT (20 mg/kg) was given in the diet for 130 months, followed by an observation p …
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-te …
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Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer.
Takayama S, Sieber SM, Adamson RH, Thorgeirsson UP, Dalgard DW, Arnold LL, Cano M, Eklund S, Cohen SM.
Takayama S, et al. Among authors: dalgard dw.
J Natl Cancer Inst. 1998 Jan 7;90(1):19-25. doi: 10.1093/jnci/90.1.19.
J Natl Cancer Inst. 1998.
PMID: 9428778
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium saccharin. PURPOSE: Our purpose was to determine the effects of long-term feeding of sodium saccharin to three species of nonhuman primates. …
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium sacchar …
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Tumor incidence in a chemical carcinogenesis study of nonhuman primates.
Thorgeirsson UP, Dalgard DW, Reeves J, Adamson RH.
Thorgeirsson UP, et al. Among authors: dalgard dw.
Regul Toxicol Pharmacol. 1994 Apr;19(2):130-51. doi: 10.1006/rtph.1994.1013.
Regul Toxicol Pharmacol. 1994.
PMID: 8041912
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "classical" rodent carcinogens, antineoplastic agents, and immunosuppressive agents have been evaluated for long-term carcinogenic activity …
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "class …
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Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates.
Sieber SM, Correa P, Dalgard DW, McIntire KR, Adamson RH.
Sieber SM, et al. Among authors: dalgard dw.
J Natl Cancer Inst. 1980 Jul;65(1):177-89.
J Natl Cancer Inst. 1980.
PMID: 6248673
Four of the monkeys developed hepatocellular carcinomas, and 2 had multiple primary tumors including hepatocellular carcinomas, renal carcinomas, squamous cell carcinomas of the esophagus, and adenocarcinomas of the small intestine. Our results showed that long-term admini …
Four of the monkeys developed hepatocellular carcinomas, and 2 had multiple primary tumors including hepatocellular carcinomas, renal carcin …
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