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Predictive Role of CD36 Expression in HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Trastuzumab.
Ligorio F, Di Cosimo S, Verderio P, Ciniselli CM, Pizzamiglio S, Castagnoli L, Dugo M, Galbardi B, Salgado R, Loi S, Michiels S, Triulzi T, Tagliabue E, El-Abed S, Izquierdo M, de Azambuja E, Nuciforo P, Huober J, Moscetti L, Janni W, Coccia-Portugal MA, Corsetto PA, Belfiore A, Lorenzini D, Daidone MG, Vingiani A, Gianni L, Pupa SM, Bianchini G, Pruneri G, Vernieri C. Ligorio F, et al. Among authors: daidone mg. J Natl Cancer Inst. 2022 Dec 8;114(12):1720-1727. doi: 10.1093/jnci/djac126. J Natl Cancer Inst. 2022. PMID: 35789270
BACKGROUND: Despite huge efforts to identify biomarkers associated with long-term clinical outcomes in patients with early-stage HER2-positive breast cancer (HER2+ BC) treated with (neo)adjuvant anti-HER2 therapy, no reliable predictors have been identified so far. ...
BACKGROUND: Despite huge efforts to identify biomarkers associated with long-term clinical outcomes in patients with early-stage HER2 …
What if the future of HER2-positive breast cancer patients was written in miRNAs? An exploratory analysis from NeoALTTO study.
Pizzamiglio S, Cosentino G, Ciniselli CM, De Cecco L, Cataldo A, Plantamura I, Triulzi T, El-Abed S, Wang Y, Bajji M, Nuciforo P, Huober J, Ellard SL, Rimm DL, Gombos A, Daidone MG, Verderio P, Tagliabue E, Di Cosimo S, Iorio MV. Pizzamiglio S, et al. Among authors: daidone mg. Cancer Med. 2022 Jan;11(2):332-339. doi: 10.1002/cam4.4449. Epub 2021 Dec 17. Cancer Med. 2022. PMID: 34921525 Free PMC article. Clinical Trial.
For two additional miRNAs (miR-215-5p and miR-30c-2-3p), we found a statistically significant interaction term with pCR (p.interaction: 0.017 and 0.038, respectively). Besides, a two-miRNA signature was predictive of pCR (hsa-miR-31-3p, OR 0.70, 95% CI: 0.53-0.92, and hsa- …
For two additional miRNAs (miR-215-5p and miR-30c-2-3p), we found a statistically significant interaction term with pCR (p.interactio …
Basic principles of biobanking: from biological samples to precision medicine for patients.
Annaratone L, De Palma G, Bonizzi G, Sapino A, Botti G, Berrino E, Mannelli C, Arcella P, Di Martino S, Steffan A, Daidone MG, Canzonieri V, Parodi B, Paradiso AV, Barberis M, Marchiò C; Alleanza Contro il Cancro (ACC) Pathology and Biobanking Working Group. Annaratone L, et al. Among authors: daidone mg. Virchows Arch. 2021 Aug;479(2):233-246. doi: 10.1007/s00428-021-03151-0. Epub 2021 Jul 13. Virchows Arch. 2021. PMID: 34255145 Free PMC article. Review.
The term "biobanking" is often misapplied to any collection of human biological materials (biospecimens) regardless of requirements related to ethical and legal issues or the standardization of different processes involved in tissue collection. ...
The term "biobanking" is often misapplied to any collection of human biological materials (biospecimens) regardless of requirements r …
SARS-CoV-2 Serology Monitoring of a Cancer Center Staff in the Pandemic Most Infected Italian Region.
Ciniselli CM, Micali A, De Cecco L, Notti P, Sinno V, Luison E, Melani CC, Daidone MG, Apolone G, Verderio P, Figini M. Ciniselli CM, et al. Among authors: daidone mg. Cancers (Basel). 2021 Mar 2;13(5):1035. doi: 10.3390/cancers13051035. Cancers (Basel). 2021. PMID: 33801186 Free PMC article.
One hundred and ten HCP answered a questionnaire and were screened by nasopharyngeal swabs as well as for IgM/IgG levels; seropositive HCPs were further screened every 40-45 days using SARS-CoV-2-specific serology. We identified a fraction of HCP with long-term anti-SARS-C …
One hundred and ten HCP answered a questionnaire and were screened by nasopharyngeal swabs as well as for IgM/IgG levels; seropositive HCPs …
How to study and overcome tumor heterogeneity with circulating biomarkers: The breast cancer case.
Appierto V, Di Cosimo S, Reduzzi C, Pala V, Cappelletti V, Daidone MG. Appierto V, et al. Among authors: daidone mg. Semin Cancer Biol. 2017 Jun;44:106-116. doi: 10.1016/j.semcancer.2017.04.007. Epub 2017 Apr 22. Semin Cancer Biol. 2017. PMID: 28442298 Review.
Such findings question whether an optimal assessment of disease progression and a screening for druggable mutations should be based on molecular features of primary or recurrent/metastatic lesions and therefore represent a crucial element for failure or success of personalized me …
Such findings question whether an optimal assessment of disease progression and a screening for druggable mutations should be based on molec …
International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fifth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2013).
Amoroso V, Generali D, Buchholz T, Cristofanilli M, Pedersini R, Curigliano G, Daidone MG, Di Cosimo S, Dowsett M, Fox S, Harris AL, Makris A, Vassalli L, Ravelli A, Cappelletti MR, Hatzis C, Hudis CA, Pedrazzoli P, Sapino A, Semiglazov V, Von Minckwitz G, Simoncini EL, Jacobs MA, Barry P, Kühn T, Darby S, Hermelink K, Symmans F, Gennari A, Schiavon G, Dogliotti L, Berruti A, Bottini A. Amoroso V, et al. Among authors: daidone mg. J Natl Cancer Inst Monogr. 2015 May;2015(51):90-6. doi: 10.1093/jncimonographs/lgv023. J Natl Cancer Inst Monogr. 2015. PMID: 26063896 Free PMC article.
Although pCR is an early clinical endpoint, its role as a surrogate for long-term outcomes is the key issue. New and better predictors of treatment efficacy are needed to improve treatment and outcomes. ...
Although pCR is an early clinical endpoint, its role as a surrogate for long-term outcomes is the key issue. New and better predictor …
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.
Orlotti NI, Cimino-Reale G, Borghini E, Pennati M, Sissi C, Perrone F, Palumbo M, Daidone MG, Folini M, Zaffaroni N. Orlotti NI, et al. Among authors: daidone mg. Autophagy. 2012 Aug;8(8):1185-96. doi: 10.4161/auto.20519. Epub 2012 May 25. Autophagy. 2012. PMID: 22627293
Elucidation of the structures of telomeric G-quadruplexes has led, in the past few years, to the rational development of effective G-quadruplex-stabilizing small molecules. In the present study, we showed that short-term exposure of melanoma cells to Ant1,5--an anthracene- …
Elucidation of the structures of telomeric G-quadruplexes has led, in the past few years, to the rational development of effective G-quadrup …
Axillary dissection versus no axillary dissection in elderly patients with breast cancer and no palpable axillary nodes: results after 15 years of follow-up.
Martelli G, Miceli R, Daidone MG, Vetrella G, Cerrotta AM, Piromalli D, Agresti R. Martelli G, et al. Among authors: daidone mg. Ann Surg Oncol. 2011 Jan;18(1):125-33. doi: 10.1245/s10434-010-1217-7. Epub 2010 Jul 23. Ann Surg Oncol. 2011. PMID: 20652755 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the long-term safety of no axillary clearance in elderly patients with breast cancer and nonpalpable axillary nodes. ...
OBJECTIVE: To assess the long-term safety of no axillary clearance in elderly patients with breast cancer and nonpalpable axillary no …
Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.
Bernardo ME, Zaffaroni N, Novara F, Cometa AM, Avanzini MA, Moretta A, Montagna D, Maccario R, Villa R, Daidone MG, Zuffardi O, Locatelli F. Bernardo ME, et al. Among authors: daidone mg. Cancer Res. 2007 Oct 1;67(19):9142-9. doi: 10.1158/0008-5472.CAN-06-4690. Cancer Res. 2007. PMID: 17909019
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.
Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG. Ponti D, et al. Among authors: daidone mg. Cancer Res. 2005 Jul 1;65(13):5506-11. doi: 10.1158/0008-5472.CAN-05-0626. Cancer Res. 2005. PMID: 15994920
Interestingly, cultured cells were CD44+/CD24- and Cx43-, overexpressed neoangiogenic and cytoprotective factors, expressed the putative stem cell marker Oct-4, and gave rise to new tumors when as few as 10(3) cells were injected into the mammary fat pad of SCID mice. Long-ter …
Interestingly, cultured cells were CD44+/CD24- and Cx43-, overexpressed neoangiogenic and cytoprotective factors, expressed the putative ste …
24 results