CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy.
Ffrench B, Gasch C, Hokamp K, Spillane C, Blackshields G, Mahgoub TM, Bates M, Kehoe L, Mooney A, Doyle R, Doyle B, O'Donnell D, Gleeson N, Hennessy BT, Stordal B, O'Riain C, Lambkin H, O'Toole S, O'Leary JJ, Gallagher MF.
Ffrench B, et al. Among authors: doyle b.
Cell Death Dis. 2017 Oct 19;8(10):e3128. doi: 10.1038/cddis.2017.379.
Cell Death Dis. 2017.
PMID: 29048400
Free PMC article.
Cisplatin treatment quickly altered the hierarchy, resulting in a three-component hierarchy dominated by the cisplatin-resistant CD10(-)/ALDH(-) CSC. This organisation was found to be hard-wired in a long-term cisplatin-adapted model, where again CD10(-)/ALDH(-) CSCs were …
Cisplatin treatment quickly altered the hierarchy, resulting in a three-component hierarchy dominated by the cisplatin-resistant CD10(-)/ALD …