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Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.
Am J Clin Nutr. 2012 Dec;96(6):1465-72. doi: 10.3945/ajcn.112.037184. Epub 2012 Nov 7.
Am J Clin Nutr. 2012.
PMID: 23134891
Free PMC article.
Clinical Trial.
DESIGN: In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholine (750 mg) or a placebo (corn oil) from 18 wk gestation through 90 d postpartum. Their infants (n = 99) were tested for short-term vi …
DESIGN: In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholin …
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.
Zeisel SH.
Zeisel SH.
IUBMB Life. 2007 Jun;59(6):380-7. doi: 10.1080/15216540701468954.
IUBMB Life. 2007.
PMID: 17613168
Free PMC article.
Review.
Choline is critical during fetal development, when it alters DNA methylation and thereby influences neural precursor cell proliferation and apoptosis. This results in long term alterations in brain structure and function, specifically memory function....
Choline is critical during fetal development, when it alters DNA methylation and thereby influences neural precursor cell proliferation and …
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