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Page 1
Postsynaptic clustering and activation of Pyk2 by PSD-95.
Bartos JA, Ulrich JD, Li H, Beazely MA, Chen Y, Macdonald JF, Hell JW. Bartos JA, et al. J Neurosci. 2010 Jan 13;30(2):449-63. doi: 10.1523/JNEUROSCI.4992-08.2010. J Neurosci. 2010. PMID: 20071509 Free PMC article.
We show that this mechanism of Pyk2 activation is critical for long-term potentiation in the hippocampus CA1 region, which is thought to underlie learning and memory....
We show that this mechanism of Pyk2 activation is critical for long-term potentiation in the hippocampus CA1 region, which is thought …
Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.
Zhang LN, Karp P, Gerard CJ, Pastor E, Laux D, Munson K, Yan Z, Liu X, Godwin S, Thomas CP, Zabner J, Shi H, Caldwell CW, Peluso R, Carter B, Engelhardt JF. Zhang LN, et al. Mol Ther. 2004 Dec;10(6):990-1002. doi: 10.1016/j.ymthe.2004.08.009. Mol Ther. 2004. PMID: 15564131 Free article.
Treatment of human CF airway epithelia with proteasome modulating agents (LLnL and doxorubicin) at the time of rAAV2 or rAAV2/5 infection dramatically enhanced CFTR gene delivery and correction of CFTR-mediated short-circuit currents. Surprisingly, these agents also facilitated l …
Treatment of human CF airway epithelia with proteasome modulating agents (LLnL and doxorubicin) at the time of rAAV2 or rAAV2/5 infection dr …
CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma.
Jain VV, Kitagaki K, Businga T, Hussain I, George C, O'shaughnessy P, Kline JN. Jain VV, et al. J Allergy Clin Immunol. 2002 Dec;110(6):867-72. doi: 10.1067/mai.2002.129371. J Allergy Clin Immunol. 2002. PMID: 12464952
Because remodeling is thought to be responsible for many of the long-term adverse effects on asthmatic patients, we evaluated whether CpG-ODNs might similarly prevent these changes using a murine model of recurrent allergen exposure. ...
Because remodeling is thought to be responsible for many of the long-term adverse effects on asthmatic patients, we evaluated whether …
In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors.
Stein CS, Kang Y, Sauter SL, Townsend K, Staber P, Derksen TA, Martins I, Qian J, Davidson BL, McCray PB Jr. Stein CS, et al. Mol Ther. 2001 Jun;3(6):850-6. doi: 10.1006/mthe.2001.0325. Mol Ther. 2001. PMID: 11407898 Free article.
These findings indicate that gene transfer with FIV-based lentiviral vectors can permanently introduce transgenes into a sufficient number of hepatocytes for long-term therapeutic effect and suggest potential clinical value of FIV-based lentiviral vectors for treatment of …
These findings indicate that gene transfer with FIV-based lentiviral vectors can permanently introduce transgenes into a sufficient number o …
Isolating a pure population of epidermal stem cells for use in tissue engineering.
Dunnwald M, Tomanek-Chalkley A, Alexandrunas D, Fishbaugh J, Bickenbach JR. Dunnwald M, et al. Exp Dermatol. 2001 Feb;10(1):45-54. doi: 10.1034/j.1600-0625.2001.100106.x. Exp Dermatol. 2001. PMID: 11168579
Although it has been known for decades that epithelial stem cells can be identified as label-retaining cells (LRCs) by long term retention of a nuclear label, isolating a pure population of stem cells has been problematic. ...
Although it has been known for decades that epithelial stem cells can be identified as label-retaining cells (LRCs) by long term rete …
Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.
Yang J, Zhou W, Zhang Y, Zidon T, Ritchie T, Engelhardt JF. Yang J, et al. J Virol. 1999 Nov;73(11):9468-77. doi: 10.1128/JVI.73.11.9468-9477.1999. J Virol. 1999. PMID: 10516055 Free PMC article.
Long-term recombinant AAV (rAAV) transgene expression in muscle has been associated with the molecular conversion of single-stranded rAAV genomes to high-molecular-weight head-to-tail circular concatamers. ...
Long-term recombinant AAV (rAAV) transgene expression in muscle has been associated with the molecular conversion of single-stranded …