Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model.
J Biol Chem. 2009 Mar 13;284(11):6885-92. doi: 10.1074/jbc.M806728200. Epub 2009 Jan 9.
J Biol Chem. 2009.
PMID: 19136563
Free PMC article.
Because the use of gentamicin to suppress disease-causing nonsense mutations will require their long term administration, the ability of PAA to reduce toxicity and increase both the level and duration of readthrough has important implications for this promising therapeutic …
Because the use of gentamicin to suppress disease-causing nonsense mutations will require their long term administration, the ability …