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Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.
Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, De Boeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Clancy JP, et al. Thorax. 2012 Jan;67(1):12-8. doi: 10.1136/thoraxjnl-2011-200393. Epub 2011 Aug 8. Thorax. 2012. PMID: 21825083 Free PMC article. Clinical Trial.
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those measurable in the respiratory tract and to long-term measures of clinical benefit. CLINICAL TRIAL NUMBER: NCT00865904....
Additional data are needed to determine how improvements detected in CFTR function secondary to VX-809 in the sweat gland relate to those me …
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Konstan MW. Konstan MW. Curr Opin Pulm Med. 2008 Nov;14(6):567-73. doi: 10.1097/MCP.0b013e32831311e8. Curr Opin Pulm Med. 2008. PMID: 18812834 Review.
The occurrence of gastrointestinal bleeding was higher in those treated with ibuprofen, but the incidence was very low. SUMMARY: Ibuprofen has now been shown in two long-term clinical trials to slow disease progression, with real-world clinical use supporting its effective …
The occurrence of gastrointestinal bleeding was higher in those treated with ibuprofen, but the incidence was very low. SUMMARY: Ibuprofen h …
Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects.
Konstan MW, Krenicky JE, Finney MR, Kirchner HL, Hilliard KA, Hilliard JB, Davis PB, Hoppel CL. Konstan MW, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):1086-91. doi: 10.1124/jpet.103.052449. Epub 2003 Jun 13. J Pharmacol Exp Ther. 2003. PMID: 12807998 Clinical Trial.
Long-term treatment with ibuprofen twice daily, at doses that achieve peak plasma concentration (Cmax) >50 microg/ml, slows progression of lung disease in patients with cystic fibrosis (CF). ...
Long-term treatment with ibuprofen twice daily, at doses that achieve peak plasma concentration (Cmax) >50 microg/ml, slows progre …
Therapies aimed at airway inflammation in cystic fibrosis.
Konstan MW. Konstan MW. Clin Chest Med. 1998 Sep;19(3):505-13, vi. doi: 10.1016/s0272-5231(05)70096-4. Clin Chest Med. 1998. PMID: 9759552 Review.
Alternate day prednisone may be beneficial, however, unacceptable adverse effects limit long-term use. Inhaled corticosteroids are under investigation as a safer alternative. ...
Alternate day prednisone may be beneficial, however, unacceptable adverse effects limit long-term use. Inhaled corticosteroids are un …
Current understanding of the inflammatory process in cystic fibrosis: onset and etiology.
Konstan MW, Berger M. Konstan MW, et al. Pediatr Pulmonol. 1997 Aug;24(2):137-42; discussion 159-61. doi: 10.1002/(sici)1099-0496(199708)24:2<137::aid-ppul13>3.0.co;2-3. Pediatr Pulmonol. 1997. PMID: 9292910
Additional studies are necessary to define the optimal antiinflammatory drugs and regimens, and to confirm their long-term safety and efficacy....
Additional studies are necessary to define the optimal antiinflammatory drugs and regimens, and to confirm their long-term safety and …