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Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!
Farrell PM, Lai HJ, Li Z, Kosorok MR, Laxova A, Green CG, Collins J, Hoffman G, Laessig R, Rock MJ, Splaingard ML. Farrell PM, et al. J Pediatr. 2005 Sep;147(3 Suppl):S30-6. doi: 10.1016/j.jpeds.2005.08.012. J Pediatr. 2005. PMID: 16202779 Clinical Trial.
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had better chest x-ray scores at diagnosis, our trial suggests that the effects of confounders such as Pseudomonas aeruginosa infections led to deter …
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had bette …
Wisconsin cystic fibrosis chest radiograph scoring system: validation and standardization for application to longitudinal studies.
Koscik RE, Kosorok MR, Farrell PM, Collins J, Peters ME, Laxova A, Green CG, Zeng L, Rusakow LS, Hardie RC, Campbell PW, Gurney JW. Koscik RE, et al. Pediatr Pulmonol. 2000 Jun;29(6):457-67. doi: 10.1002/(sici)1099-0496(200006)29:6<457::aid-ppul8>3.0.co;2-9. Pediatr Pulmonol. 2000. PMID: 10821728
Quantitative chest radiology applied to children with cystic fibrosis studied long-term in longitudinal research projects requires the careful use of sensitive scoring methods and careful selection and training of multiple raters. ...
Quantitative chest radiology applied to children with cystic fibrosis studied long-term in longitudinal research projects requires th …
Cystic fibrosis newborn screening: impact on reproductive behavior and implications for genetic counseling.
Mischler EH, Wilfond BS, Fost N, Laxova A, Reiser C, Sauer CM, Makholm LM, Shen G, Feenan L, McCarthy C, Farrell PM. Mischler EH, et al. Pediatrics. 1998 Jul;102(1 Pt 1):44-52. doi: 10.1542/peds.102.1.44. Pediatrics. 1998. PMID: 9651412 Clinical Trial.
There were 3 pregnancies with CF detected, all of which were carried to term. In the false-positive groups, >95% of families initially understood that their child definitely did not have CF. ...
There were 3 pregnancies with CF detected, all of which were carried to term. In the false-positive groups, >95% of families initi …
Long-term mechanical ventilation in pediatric respiratory failure: medical and ethical considerations.
Farrell PM, Fost NC. Farrell PM, et al. Am Rev Respir Dis. 1989 Aug;140(2 Pt 2):S36-40. doi: 10.1164/ajrccm/140.2_Pt_2.S36. Am Rev Respir Dis. 1989. PMID: 2504092
Because the survival and quality of life for children receiving long-term assisted ventilation are not highly discouraging, increasing numbers of pediatric patients are not being managed at home with life-support technology. ...
Because the survival and quality of life for children receiving long-term assisted ventilation are not highly discouraging, increasin …