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Early autologous stem cell transplantation for chronic lymphocytic leukemia: long-term follow-up of the German CLL Study Group CLL3 trial.
Dreger P, Döhner H, McClanahan F, Busch R, Ritgen M, Greinix H, Fink AM, Knauf W, Stadler M, Pfreundschuh M, Dührsen U, Brittinger G, Hensel M, Schetelig J, Winkler D, Bühler A, Kneba M, Schmitz N, Hallek M, Stilgenbauer S; German CLL Study Group. Dreger P, et al. Blood. 2012 May 24;119(21):4851-9. doi: 10.1182/blood-2011-09-378505. Epub 2012 Apr 5. Blood. 2012. PMID: 22490331 Free article. Clinical Trial.
The CLL3 trial was designed to study intensive treatment including autologous stem cell transplantation (autoSCT) as part of first-line therapy in patients with chronic lymphocytic leukemia (CLL). Here, we present the long-term outcome of the trial with particular focus on …
The CLL3 trial was designed to study intensive treatment including autologous stem cell transplantation (autoSCT) as part of first-line ther …
Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence.
Bragonzi A, Paroni M, Nonis A, Cramer N, Montanari S, Rejman J, Di Serio C, Döring G, Tümmler B. Bragonzi A, et al. Among authors: doring g. Am J Respir Crit Care Med. 2009 Jul 15;180(2):138-45. doi: 10.1164/rccm.200812-1943OC. Epub 2009 May 7. Am J Respir Crit Care Med. 2009. PMID: 19423715
RATIONALE: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas aeruginosa strains develop mutations leading to clonal expansion. ...
RATIONALE: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas aeruginosa strains develop mutations le …
Once-weekly azithromycin in cystic fibrosis with chronic Pseudomonas aeruginosa infection.
Steinkamp G, Schmitt-Grohe S, Döring G, Staab D, Pfründer D, Beck G, Schubert R, Zielen S. Steinkamp G, et al. Among authors: doring g. Respir Med. 2008 Nov;102(11):1643-53. doi: 10.1016/j.rmed.2008.03.009. Epub 2008 Aug 12. Respir Med. 2008. PMID: 18701270 Free article. Clinical Trial.
BACKGROUND: Data on the effects of long-term treatment with azithromycin (AZM) on inflammatory markers in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa are scarce. ...
BACKGROUND: Data on the effects of long-term treatment with azithromycin (AZM) on inflammatory markers in cystic fibrosis patients ch …
Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice.
Sousa SA, Ulrich M, Bragonzi A, Burke M, Worlitzsch D, Leitão JH, Meisner C, Eberl L, Sá-Correia I, Döring G. Sousa SA, et al. Among authors: doring g. Cell Microbiol. 2007 Dec;9(12):2817-25. doi: 10.1111/j.1462-5822.2007.00998.x. Epub 2007 Jul 11. Cell Microbiol. 2007. PMID: 17627623
In cystic fibrosis (CF), infection with Burkholderia cepacia complex (Bcc) strains may cause long-term asymptomatic airway colonization, or severe lung infection leading to rapid pulmonary decline. ...
In cystic fibrosis (CF), infection with Burkholderia cepacia complex (Bcc) strains may cause long-term asymptomatic airway colonizati …
Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosis.
Montanari S, Oliver A, Salerno P, Mena A, Bertoni G, Tümmler B, Cariani L, Conese M, Döring G, Bragonzi A. Montanari S, et al. Among authors: doring g. Microbiology (Reading). 2007 May;153(Pt 5):1445-1454. doi: 10.1099/mic.0.2006/003400-0. Microbiology (Reading). 2007. PMID: 17464058 Free article.
The high prevalence of hypermutable (mismatch repair-deficient) Pseudomonas aeruginosa strains in patients with cystic fibrosis (CF) is thought to be driven by their co-selection with adaptive mutations required for long-term persistence. Whether the increased mutation rat …
The high prevalence of hypermutable (mismatch repair-deficient) Pseudomonas aeruginosa strains in patients with cystic fibrosis (CF) is thou …
Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis.
Paul K, Rietschel E, Ballmann M, Griese M, Worlitzsch D, Shute J, Chen C, Schink T, Döring G, van Koningsbruggen S, Wahn U, Ratjen F; Bronchoalveolar Lavage for the Evaluation of Antiinflammatory Treatment Study Group. Paul K, et al. Among authors: doring g. Am J Respir Crit Care Med. 2004 Mar 15;169(6):719-25. doi: 10.1164/rccm.200307-959OC. Epub 2003 Dec 18. Am J Respir Crit Care Med. 2004. PMID: 14684561 Clinical Trial.
Recombinant human deoxyribonuclease (rhDNase) has been shown to improve lung function and reduce the number of pulmonary exacerbations in patients with cystic fibrosis (CF), but its long-term effect on airway inflammation remains unknown. In this study, we used bronchoalve …
Recombinant human deoxyribonuclease (rhDNase) has been shown to improve lung function and reduce the number of pulmonary exacerbations in pa …
Inflammation in cystic fibrosis and its management.
Döring G, Worlitzsch D. Döring G, et al. Paediatr Respir Rev. 2000 Jun;1(2):101-6. doi: 10.1053/prrv.2000.0030. Paediatr Respir Rev. 2000. PMID: 12531101 Review.
Pulmonary complications are by far the most serious complications in cystic fibrosis (CF). In response to endobronchial bacterial infections, the long-term consequences of chronically activated polymorphonuclear leukocytes (neutrophils) are thought to cause loss of lung fu …
Pulmonary complications are by far the most serious complications in cystic fibrosis (CF). In response to endobronchial bacterial infections …
MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients.
Viglio S, Iadarola P, Lupi A, Trisolini R, Tinelli C, Balbi B, Grassi V, Worlitzsch D, Döring G, Meloni F, Meyer KC, Dowson L, Hill SL, Stockley RA, Luisetti M. Viglio S, et al. Among authors: doring g. Eur Respir J. 2000 Jun;15(6):1039-45. doi: 10.1034/j.1399-3003.2000.01511.x. Eur Respir J. 2000. PMID: 10885422 Free article.
The highest desmosine levels were found in subjects with alpha1-antitrypsin deficiency, bronchiectasis and cystic fibrosis (p<0.001 versus stable COPD). In a short-term longitudinal study, five stable COPD patients showed a constant rate of desmosine excretion (mean coe …
The highest desmosine levels were found in subjects with alpha1-antitrypsin deficiency, bronchiectasis and cystic fibrosis (p<0.001 versu …
Long-term tobramycin aerosol therapy in cystic fibrosis.
Steinkamp G, Tümmler B, Gappa M, Albus A, Potel J, Döring G, von der Hardt H. Steinkamp G, et al. Among authors: doring g. Pediatr Pulmonol. 1989;6(2):91-8. doi: 10.1002/ppul.1950060207. Pediatr Pulmonol. 1989. PMID: 2494640
The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibrosis has not been fully investigated. ...The study demonstrates the safety and clinical efficacy of long-term tobramycin aerosol thera …
The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibro …
12 results