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Chemical Markers for Short- and Long-Term Areca Nut Exposure.
Franke AA, Li X, Custer LJ, Lai JF. Franke AA, et al. Among authors: custer lj. Subst Use Misuse. 2020;55(9):1395-1402. doi: 10.1080/10826084.2019.1630442. Epub 2019 Jun 27. Subst Use Misuse. 2020. PMID: 31244365 Free PMC article.
AN cessation programs are the most effective approach to reduce AN chewing induced cancers but require biomarkers to determine program compliance and success. Objectives: To explore chemical markers for short- and long-term AN exposure using non-invasively collected saliva …
AN cessation programs are the most effective approach to reduce AN chewing induced cancers but require biomarkers to determine program compl …
In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.
Torous DK, Phonethepswath S, Avlasevich SL, Mereness J, Bryce SM, Bemis JC, Weller P, Bell S, Gleason C, Custer LL, MacGregor JT, Dertinger SD. Torous DK, et al. Among authors: custer ll. Environ Mol Mutagen. 2012 Jul;53(6):420-8. doi: 10.1002/em.21709. Epub 2012 Jun 22. Environ Mol Mutagen. 2012. PMID: 22730284
This laboratory has developed flow cytometric scoring techniques for monitoring two blood-based genotoxicity endpoints-micronucleated reticulocyte frequency and gene mutation at the Pig-a locus-thereby making combination and integration studies practical. The ability to effective …
This laboratory has developed flow cytometric scoring techniques for monitoring two blood-based genotoxicity endpoints-micronucleated reticu …
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies.
Rothfuss A, O'Donovan M, De Boeck M, Brault D, Czich A, Custer L, Hamada S, Plappert-Helbig U, Hayashi M, Howe J, Kraynak AR, van der Leede BJ, Nakajima M, Priestley C, Thybaud V, Saigo K, Sawant S, Shi J, Storer R, Struwe M, Vock E, Galloway S. Rothfuss A, et al. Among authors: custer l. Mutat Res. 2010 Sep 30;702(1):40-69. doi: 10.1016/j.mrgentox.2010.07.006. Epub 2010 Jul 23. Mutat Res. 2010. PMID: 20656055
There was a high concordance between short- and long-term Comet assay results. Most compounds when tested up to the maximum tolerated dose were correctly detected in both short- and long-term studies. Discrepant results were obtained with 2,6 diaminotoluene (negativ …
There was a high concordance between short- and long-term Comet assay results. Most compounds when tested up to the maximum tolerated …
The role of genetic toxicology in drug discovery and optimization.
Custer LL, Sweder KS. Custer LL, et al. Curr Drug Metab. 2008 Nov;9(9):978-85. doi: 10.2174/138920008786485191. Curr Drug Metab. 2008. PMID: 18991595 Review.
Genetic toxicology data is used as a surrogate for long-term carcinogenicity data during early drug development. The aim of genotoxicity testing is to identify potentially hazardous drug candidates. ...
Genetic toxicology data is used as a surrogate for long-term carcinogenicity data during early drug development. The aim of genotoxic …
The syrian hamster embryo (SHE) cell transformation assay: review of the methods and results.
Mauthe RJ, Gibson DP, Bunch RT, Custer L. Mauthe RJ, et al. Among authors: custer l. Toxicol Pathol. 2001;29 Suppl:138-46. doi: 10.1080/019262301753178546. Toxicol Pathol. 2001. PMID: 11695550
The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. ...The SHE assay models the earliest identifiable stage in ca …
The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcino …
Reproducibility of erythrocyte polyamine measurements and correlation with plasma micronutrients in an antioxidant vitamin intervention study.
Wang W, Kucuk O, Franke AA, Liu LQ, Custer LJ, Higuchi CM. Wang W, et al. Among authors: custer lj. J Cell Biochem. 1996 Jul;62(1):19-26. doi: 10.1002/(sici)1097-4644(199607)62:1<19::aid-jcb3>3.0.co;2-4. J Cell Biochem. 1996. PMID: 8836872 Clinical Trial.
For all the measures of erythrocyte polyamines the intraindividual variation was smaller than that between subjects, and three or four measurements required to accurately characterize long-term erythrocyte polyamines for an individual. The intra-class correlations were mod …
For all the measures of erythrocyte polyamines the intraindividual variation was smaller than that between subjects, and three or four measu …
Seasonal variations in plasma micronutrients and antioxidants.
Cooney RV, Franke AA, Hankin JH, Custer LJ, Wilkens LR, Harwood PJ, Le Marchand L. Cooney RV, et al. Among authors: custer lj. Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):207-15. Cancer Epidemiol Biomarkers Prev. 1995. PMID: 7606195
The number of samples required to accurately characterize long-term plasma levels for an individual generally ranged from 1 to 4. ...
The number of samples required to accurately characterize long-term plasma levels for an individual generally ranged from 1 to 4. ...