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Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors.
Gulej R, Nyúl-Tóth Á, Csik B, Petersen B, Faakye J, Negri S, Chandragiri SS, Mukli P, Yabluchanskiy A, Conley S, Huffman DM, Csiszar A, Tarantini S, Ungvari Z. Gulej R, et al. Among authors: csiszar a. Geroscience. 2024 Feb;46(1):327-347. doi: 10.1007/s11357-023-01039-2. Epub 2023 Dec 21. Geroscience. 2024. PMID: 38123890 Free PMC article.
In conclusion, even a brief exposure to a youthful humoral environment can mitigate neurovascular aging phenotypes, rejuvenating NVC responses. Conversely, short-term exposure to an aged humoral milieu in young mice accelerates the acquisition of neurovascular aging traits …
In conclusion, even a brief exposure to a youthful humoral environment can mitigate neurovascular aging phenotypes, rejuvenating NVC respons …
Whole brain irradiation-induced endothelial dysfunction in the mouse brain.
Kiss T, Ungvari A, Gulej R, Nyúl-Tóth Á, Tarantini S, Benyo Z, Csik B, Yabluchanskiy A, Mukli P, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: csiszar a. Geroscience. 2024 Feb;46(1):531-541. doi: 10.1007/s11357-023-00990-4. Epub 2023 Nov 13. Geroscience. 2024. PMID: 37953375 Free PMC article.
These findings provide additional preclinical evidence supporting the notion that WBI induces dysfunction in cerebrovascular endothelial cells, which in turn likely contributes to the detrimental long-term effects of the treatment. This endothelial dysfunction resembles an …
These findings provide additional preclinical evidence supporting the notion that WBI induces dysfunction in cerebrovascular endothelial cel …
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
Owens CD, Mukli P, Csipo T, Lipecz A, Silva-Palacios F, Dasari TW, Tarantini S, Gardner AW, Montgomery PS, Waldstein SR, Kellawan JM, Nyul-Toth A, Balasubramanian P, Sotonyi P, Csiszar A, Ungvari Z, Yabluchanskiy A. Owens CD, et al. Among authors: csiszar a. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H924-H935. doi: 10.1152/ajpheart.00616.2021. Epub 2022 Mar 25. Am J Physiol Heart Circ Physiol. 2022. PMID: 35333116 Free PMC article.
We found that cognitive performance was compromised in patients with PAD, evidenced by reduced visual memory, short-term memory, and sustained attention. We found that NVC responses and peripheral microvascular endothelial function were significantly impaired in patients w …
We found that cognitive performance was compromised in patients with PAD, evidenced by reduced visual memory, short-term memory, and …
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Kiss T, Nyúl-Tóth Á, Gulej R, Tarantini S, Csipo T, Mukli P, Ungvari A, Balasubramanian P, Yabluchanskiy A, Benyo Z, Conley SM, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: csiszar a. Geroscience. 2022 Apr;44(2):953-981. doi: 10.1007/s11357-022-00519-1. Epub 2022 Feb 5. Geroscience. 2022. PMID: 35124764 Free PMC article.
IPA Upstream Regulator analysis (performed to identify upstream transcriptional regulators that may contribute to the observed transcriptomic changes) suggests that the mechanism of action of pro-geronic factors present in old blood may include inhibition of pathways mediated by …
IPA Upstream Regulator analysis (performed to identify upstream transcriptional regulators that may contribute to the observed transcriptomi …
Cognitive decrement in older adults with symptomatic peripheral artery disease.
Gardner AW, Montgomery PS, Wang M, Shen B, Casanegra AI, Silva-Palacios F, Ungvari Z, Yabluchanskiy A, Csiszar A, Waldstein SR. Gardner AW, et al. Among authors: csiszar a. Geroscience. 2021 Oct;43(5):2455-2465. doi: 10.1007/s11357-021-00437-8. Epub 2021 Sep 9. Geroscience. 2021. PMID: 34498199 Free PMC article.
Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.
Csipo T, Lipecz A, Mukli P, Bahadli D, Abdulhussein O, Owens CD, Tarantini S, Hand RA, Yabluchanska V, Kellawan JM, Sorond F, James JA, Csiszar A, Ungvari ZI, Yabluchanskiy A. Csipo T, et al. Among authors: csiszar a. PLoS One. 2021 May 19;16(5):e0250043. doi: 10.1371/journal.pone.0250043. eCollection 2021. PLoS One. 2021. PMID: 34010279 Free PMC article.
Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.
Institoris A, Murphy-Royal C, Tarantini S, Yabluchanskiy A, Haidey JN, Csiszar A, Ungvari Z, Gordon GR. Institoris A, et al. Among authors: csiszar a. Geroscience. 2021 Feb;43(1):197-212. doi: 10.1007/s11357-020-00289-8. Epub 2020 Oct 22. Geroscience. 2021. PMID: 33094399 Free PMC article.
Astrocytic Ca(2+) responses induced by bath administration of phenylephrine (detected with Rhod-2/AM) were also unaltered by WBI. However, an electrical stimulation protocol used in long-term potentiation (theta burst), revealed attenuated astrocyte Ca(2+) responses in the …
Astrocytic Ca(2+) responses induced by bath administration of phenylephrine (detected with Rhod-2/AM) were also unaltered by WBI. However, a …
Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
Kiss T, Tarantini S, Csipo T, Balasubramanian P, Nyúl-Tóth Á, Yabluchanskiy A, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: csiszar a. Geroscience. 2020 Apr;42(2):727-748. doi: 10.1007/s11357-020-00180-6. Epub 2020 Mar 15. Geroscience. 2020. PMID: 32172434 Free PMC article.
Pathway analysis shows that vascular protective effects mediated by young blood-regulated genes include mitochondrial rejuvenation. In conclusion, a relatively short-term exposure to young blood can rescue vascular aging phenotypes, including attenuation of oxidative stres …
Pathway analysis shows that vascular protective effects mediated by young blood-regulated genes include mitochondrial rejuvenation. In concl …
Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
Tarantini S, Yabluchanskiy A, Csipo T, Fulop G, Kiss T, Balasubramanian P, DelFavero J, Ahire C, Ungvari A, Nyúl-Tóth Á, Farkas E, Benyo Z, Tóth A, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: csiszar a. Geroscience. 2019 Oct;41(5):533-542. doi: 10.1007/s11357-019-00101-2. Epub 2019 Nov 2. Geroscience. 2019. PMID: 31679124 Free PMC article.
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