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Pesticide exposure and the microbiota-gut-brain axis.
Matsuzaki R, Gunnigle E, Geissen V, Clarke G, Nagpal J, Cryan JF. Matsuzaki R, et al. Among authors: cryan jf. ISME J. 2023 Aug;17(8):1153-1166. doi: 10.1038/s41396-023-01450-9. Epub 2023 Jun 16. ISME J. 2023. PMID: 37328570 Free PMC article. Review.
Given the widespread use of pesticides in modern agriculture practices, it is important to assess the long-term collateral effects these xenobiotic exposures have on gut microbiota composition and function. ...
Given the widespread use of pesticides in modern agriculture practices, it is important to assess the long-term collateral effects th …
Safety and feasibility of faecal microbiota transplant for major depressive disorder: study protocol for a pilot randomised controlled trial.
Green JE, McGuinness AJ, Berk M, Castle D, Athan E, Hair C, Strandwitz P, Loughman A, Nierenberg AA, Cryan JF, Mohebbi M, Jacka F. Green JE, et al. Among authors: cryan jf. Pilot Feasibility Stud. 2023 Jan 9;9(1):5. doi: 10.1186/s40814-023-01235-z. Pilot Feasibility Stud. 2023. PMID: 36624505 Free PMC article.
METHODS AND DESIGN: This protocol describes an 8-week, triple-blind, 2:1 parallel group, randomised controlled pilot trial (n = 15), of enema-delivered FMT treatment (n = 10) compared with a placebo enema (n = 5) in adults with moderate-to-severe MDD. There will be a further 26-w …
METHODS AND DESIGN: This protocol describes an 8-week, triple-blind, 2:1 parallel group, randomised controlled pilot trial (n = 15), of enem …
Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment.
Lynch CMK, Cowan CSM, Bastiaanssen TFS, Moloney GM, Theune N, van de Wouw M, Florensa Zanuy E, Ventura-Silva AP, Codagnone MG, Villalobos-Manríquez F, Segalla M, Koc F, Stanton C, Ross P, Dinan TG, Clarke G, Cryan JF. Lynch CMK, et al. Among authors: cryan jf. Brain Behav Immun. 2023 Feb;108:309-327. doi: 10.1016/j.bbi.2022.12.008. Epub 2022 Dec 17. Brain Behav Immun. 2023. PMID: 36535610 Free article.
Epidemiological studies have shown that early-life antibiotic exposure can increase an individual's risk of developing immune and metabolic diseases. Moreover, preclinical studies have shown that long-term antibiotic-induced microbial disruption in early life can have endu …
Epidemiological studies have shown that early-life antibiotic exposure can increase an individual's risk of developing immune and metabolic …
The effect of exercise interventions on inflammatory markers in major depressive disorder: protocol for a systematic review and meta-analysis.
Grunberg D, Martin JA, Cryan JF, O'Halloran KD, Kelleher E, Dinan TG, Clarke G. Grunberg D, et al. Among authors: cryan jf. HRB Open Res. 2022 Jun 15;4:42. doi: 10.12688/hrbopenres.13240.3. eCollection 2021. HRB Open Res. 2022. PMID: 36263316 Free PMC article.
Methods: Electronic databases (APA PsycINFO, and PubMed/MEDLINE (EBSCO interface), EMBASE) will be searched using a detailed search strategy comprised of three search term themes: exercise, depression/MDD, and inflammation/inflammatory molecules. ...
Methods: Electronic databases (APA PsycINFO, and PubMed/MEDLINE (EBSCO interface), EMBASE) will be searched using a detailed search strategy …
Distinct post-sepsis induced neurochemical alterations in two mouse strains.
Browne CA, Clarke G, Fitzgerald P, O'Sullivan J, Dinan TG, Cryan JF. Browne CA, et al. Among authors: cryan jf. Brain Behav Immun. 2022 Aug;104:39-53. doi: 10.1016/j.bbi.2022.05.005. Epub 2022 May 13. Brain Behav Immun. 2022. PMID: 35569797
Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairment or global loss of cognitive function. Currently there is no clearly defined neurochemical basis of septic encephalopathy. ...
Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairm …
Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner.
Costa A, Rani B, Bastiaanssen TFS, Bonfiglio F, Gunnigle E, Provensi G, Rossitto M, Boehme M, Strain C, Martínez CS, Blandina P, Cryan JF, Layé S, Corradetti R, Passani MB. Costa A, et al. Among authors: cryan jf. Int J Mol Sci. 2022 Jan 13;23(2):862. doi: 10.3390/ijms23020862. Int J Mol Sci. 2022. PMID: 35055048 Free PMC article.
Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc(-/-) and Hdc(+/+) mice. ...
Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota …
Altered stress responses in adults born by Caesarean section.
Dinan TG, Kennedy PJ, Morais LH, Murphy A, Long-Smith CM, Moloney GM, Bastiaanssen TFS, Allen AP, Collery A, Mullins D, Cusack AM, Berding K, O'Toole PW, Clarke G, Stanton C, Cryan JF. Dinan TG, et al. Among authors: cryan jf. Neurobiol Stress. 2021 Dec 28;16:100425. doi: 10.1016/j.ynstr.2021.100425. eCollection 2022 Jan. Neurobiol Stress. 2021. PMID: 35024387 Free PMC article.
Birth by Caesarean-section (C-section), which increases the risk for metabolic and immune disorders, disrupts the normal initial microbial colonisation of the gut, in addition to preventing early priming of the stress and immune-systems.. Animal studies have shown there ar …
Birth by Caesarean-section (C-section), which increases the risk for metabolic and immune disorders, disrupts the normal initial micr …
The impact of the prolonged COVID-19 pandemic on stress resilience and mental health: A critical review across waves.
Manchia M, Gathier AW, Yapici-Eser H, Schmidt MV, de Quervain D, van Amelsvoort T, Bisson JI, Cryan JF, Howes OD, Pinto L, van der Wee NJ, Domschke K, Branchi I, Vinkers CH. Manchia M, et al. Among authors: cryan jf. Eur Neuropsychopharmacol. 2022 Feb;55:22-83. doi: 10.1016/j.euroneuro.2021.10.864. Epub 2021 Oct 29. Eur Neuropsychopharmacol. 2022. PMID: 34818601 Free PMC article. Review.
There is a vast and rapidly growing literature that has examined the impact of the pandemic on mental health both on the shorter (2020) and longer (2021) term. This not only concerns pandemic-related effects on resilience in the general population, but also how the pandemi …
There is a vast and rapidly growing literature that has examined the impact of the pandemic on mental health both on the shorter (2020) and …
High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner.
Yanguas-Casás N, Torres C, Crespo-Castrillo A, Diaz-Pacheco S, Healy K, Stanton C, Chowen JA, Garcia-Segura LM, Arevalo MA, Cryan JF, de Ceballos ML. Yanguas-Casás N, et al. Among authors: cryan jf. Neurobiol Dis. 2021 Nov;159:105495. doi: 10.1016/j.nbd.2021.105495. Epub 2021 Aug 31. Neurobiol Dis. 2021. PMID: 34478848 Free article.
Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor for Alzheimer's disease (AD). ...
Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor fo …
Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse.
Morais LH, Golubeva AV, Casey S, Scott KA, Ramos Costa AP, Moloney GM, Dinan TG, Cryan JF. Morais LH, et al. Among authors: cryan jf. Neuropsychopharmacology. 2021 Oct;46(11):1958-1968. doi: 10.1038/s41386-021-01040-3. Epub 2021 May 26. Neuropsychopharmacology. 2021. PMID: 34040156 Free PMC article.
The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in …
The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the ae …
49 results